GSK3B

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

glycogen synthase kinase 3 beta

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

3:q13.33 (119821323 - 120094417)

Ensembl ID

ENSG00000082701  (ver. 84.38)

Orthologs

Mouse Gsk3b: ENSMUSG00000022812

UniProt

P49841

neXtProt

NX_P49841

Human splice variants
Mouse splice variants