20634-1-AP

antibody from Proteintech Group

Targeting: CXCR2 CD182, CMKAR2, IL8RB

Provider product page for 20634-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 20634-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20634-1-AP, RRID:AB_10693624
Product name: CXCR2 antibody
Antibody type: Polyclonal
Description: CXCR2 antibody (Cat. #20634-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CXCR2 protein structure - 20634-1-AP shown in red.

Submitted references Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer.

Yang Y, Chen Y, Liu Z, Chang Z, Sun Z, Zhao L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101351

Osteocytes support bone metastasis of melanoma cells by CXCL5.

Jia Y, Zhang F, Meng X, Andreev D, Lyu P, Zhang W, Lai C, Schett G, Bozec A
Cancer letters 2024 May 28;590:216866

Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.

Cui S, Chen X, Li J, Wang W, Meng D, Zhu S, Shen S
Cell communication and signaling : CCS 2024 Mar 25;22(1):191

Neuroprotective Effects of CXCR2 Antagonist SB332235 on Traumatic Brain Injury Through Suppressing NLRP3 Inflammasome.

Zhao K, Zhou X, Chen M, Gou L, Mei D, Gao C, Zhao S, Luo S, Wang X, Tan T, Zhang Y
Neurochemical research 2024 Jan;49(1):184-198

Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway.

Tatsuno R, Ichikawa J, Komohara Y, Pan C, Kawasaki T, Enomoto A, Aoki K, Hayakawa K, Iwata S, Jubashi T, Haro H
Cell death & disease 2024 Feb 1;15(2):108

Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel finding.

Wei Y, Zheng X, Huang T, Zhong Y, Sun S, Wei X, Liu Q, Wang T, Zhao Z
PloS one 2023;18(8):e0288281

CXCR2 antagonism attenuates neuroinflammation after subarachnoid hemorrhage.

Luo X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Sep;32(9):107266

Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8(+) T cell.

Xu F, Wang X, Huang Y, Zhang X, Sun W, Du Y, Xu Z, Kou H, Zhu S, Liu C, Wei X, Li X, Jiang Q, Xu Y
Cell reports 2023 Nov 28;42(11):113424

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.

Luo S, Liao C, Zhang L, Ling C, Zhang X, Xie P, Su G, Chen Z, Zhang L, Lai T, Tang J
Cell reports 2023 Mar 28;42(3):112259

C-X-C Motif Chemokine 3 Promotes the Inflammatory Response of Microglia after Escherichia coli-Induced Meningitis.

Qu X, Dou B, Yang R, Tan C, Chen H, Wang X
International journal of molecular sciences 2023 Jun 21;24(13)

Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.

Ye S, Huang H, Xiao Y, Han X, Shi F, Luo W, Chen J, Ye Y, Zhao X, Huang W, Wang Y, Lai D, Liang G, Fu G
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184

Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.

Wang X, Xu F, Kou H, Zheng Y, Yang J, Xu Z, Fang Y, Sun W, Zhu S, Jiang Q, Wei X, Xu Y
Journal of extracellular vesicles 2023 Jul;12(7):e12342

Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.

Qin H, Zhuang W, Liu X, Wu J, Li S, Wang Y, Liu X, Chen C, Zhang H
Cell reports 2023 Jul 25;42(7):112745

Skewing cPLA(2)α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis.

Maus KD, Stephenson DJ, Macknight HP, Vu NT, Hoeferlin LA, Kim M, Diegelmann RF, Xie X, Chalfant CE
Science signaling 2023 Jul 11;16(793):eadd6527

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.

Yang N, Li M, Wu L, Song Y, Yu S, Wan Y, Cheng W, Yang B, Mou X, Yu H, Zheng J, Li X, Yu X
Journal of nanobiotechnology 2023 Jan 13;21(1):13

CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.

Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)

DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.

Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Sasaguri T
International immunopharmacology 2023 Apr;117:109913

SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.

Tang L, Peng L, Liu H, Xiao T, Gu W, Yang H, Wang H, Chen P
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):214

Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.

Yao YZ, Liao ZK, Jiang S, Dong BQ, Luo LF, Miao F, Lei TC
Journal of dermatological science 2022 Nov;108(2):98-108

IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.

Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122

STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.

Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X, Zhang M
Frontiers in molecular biosciences 2021;8:717962

The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response.

Tang H, Yang M, Liu Y, Liu H, Sun L, Song P
Frontiers in physiology 2021;12:782677

CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.

Zhang S, Ding J, Wang J, Yin T, Zhang Y, Yang J
Frontiers in immunology 2021;12:717483

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.

Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)

IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.

Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402

XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.

Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, Lin Y, Wang Z
Cell communication and signaling : CCS 2020 Mar 26;18(1):48

Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.

Dominguez C, McCampbell KK, David JM, Palena C
JCI insight 2017 Nov 2;2(21)

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: L02 cells were subjected to SDS PAGE followed by western blot with 20634-1-AP(IL8RB antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using IL8RB antibody 20634-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line