Antibody data
- Antibody Data
- Antigen structure
- References [58]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 20634-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20634-1-AP, RRID:AB_10693624
- Product name
- CXCR2 antibody
- Antibody type
- Polyclonal
- Description
- CXCR2 antibody (Cat. #20634-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver Injury.
CXCL2 Mediates Lactate Secretion and Promotes Aortic Dissection Formation through the p38/JNK/C-myc Pathways.
A SASP-related four-gene signature associated with intervertebral disc degeneration: integrated bioinformatics analysis and validation of pinocembrin as a therapeutic candidate.
Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs-Macrophage Crosstalk.
CXCL7/CXCR2 in the paraventricular thalamus mediates obesity-related pain.
IL-8/CXCR2 mediates resistance to apatinib through PI3K/AKT and vasculogenic mimicry in gastric cancer cells.
Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance.
Diagnostic potential of neutrophil extracellular traps in ulcerative colitis: a gene-based predictive model.
Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal-induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney stones.
Tumor-Associated Macrophage-Derived CXCL1 Promotes Endometrial Cancer Progression Through the CXCR2/NF-κB Pathway.
Mechanistic Study of CD90-Positive Synovial Fibroblasts in the Invasion and Recurrence of Pigmented Villonodular Synovitis.
Identification of shared biomarkers and potential therapeutic targets for antiphospholipid syndrome and recurrent miscarriage by integrated bioinformatics analysis and machine learning.
Targeting HPK1 inhibits neutrophil responses to mitigate post-stroke lung and cerebral injuries.
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery.
CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance.
DSG2 promotes pancreatic cancer stem cell maintenance via support of tumour and macrophage cellular cross-talk.
CXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain.
CXCL6 Orchestrates Macrophage-Driven Inflammation in Diabetic Kidney Disease and Represents a Druggable Target.
Association between cytokines and progression-free survival in ovarian cancer following CRS/HIPEC treatment.
Lichong decoction improves inflammatory microenvironment and alleviates fibrosis in uterine leiomyoma via targeting CXCL8.
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury.
RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer.
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis.
Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells.
Langhans giant cells regulate cutaneous immune responses during mycobacterial infection through CXCL1/CXCL2 secretion.
Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer.
Comprehensive Analysis of scRNA-Seq and Bulk RNA-Seq Reveals Transcriptional Signatures of Macrophages in Intrahepatic Cholestasis of Pregnancy.
Quercetin alleviates ulcerative colitis through inhibiting CXCL8-CXCR1/2 axis: a network and transcriptome analysis.
GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease.
Osteocytes support bone metastasis of melanoma cells by CXCL5.
Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance.
Neuroprotective Effects of CXCR2 Antagonist SB332235 on Traumatic Brain Injury Through Suppressing NLRP3 Inflammasome.
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway.
Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models.
Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel finding.
CXCR2 antagonism attenuates neuroinflammation after subarachnoid hemorrhage.
Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8(+) T cell.
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
C-X-C Motif Chemokine 3 Promotes the Inflammatory Response of Microglia after Escherichia coli-Induced Meningitis.
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.
Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.
Skewing cPLA(2)α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis.
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.
SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.
Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response.
CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.
Wang X, Zhan X, Gao Y, Wang H, Liu Z, Liu M, Lu L, Zhou H
Cellular and molecular gastroenterology and hepatology 2026;20(2):101674
Cellular and molecular gastroenterology and hepatology 2026;20(2):101674
CXCL2 Mediates Lactate Secretion and Promotes Aortic Dissection Formation through the p38/JNK/C-myc Pathways.
Li J, Qiu Z, Xie R, Ma L, Tang L, Yao M, Zhang Z, Chen L, Zhang L
Thrombosis and haemostasis 2026 Mar;126(3):260-275
Thrombosis and haemostasis 2026 Mar;126(3):260-275
A SASP-related four-gene signature associated with intervertebral disc degeneration: integrated bioinformatics analysis and validation of pinocembrin as a therapeutic candidate.
Yao GL, Wang SJ, Zhang Y, Liu JM, Song HH, Liu ZL
Molecular biology reports 2026 Mar 21;53(1)
Molecular biology reports 2026 Mar 21;53(1)
Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs-Macrophage Crosstalk.
Chen Y, Lei R, Guo Q, Liu K, Cheng H, Yu S, Li Y, He P, Yang S
ACS nano 2026 Mar 17;20(10):8936-8957
ACS nano 2026 Mar 17;20(10):8936-8957
CXCL7/CXCR2 in the paraventricular thalamus mediates obesity-related pain.
Hu R, Lu Q, Liu Y, Zhang Y, Liu W, Yan W, Weng L, Jia B, Lu L, Zhang Y, Peng K, Xue Q, Huang C
Journal of neuroinflammation 2026 Jan 13;23(1):56
Journal of neuroinflammation 2026 Jan 13;23(1):56
IL-8/CXCR2 mediates resistance to apatinib through PI3K/AKT and vasculogenic mimicry in gastric cancer cells.
Fan YW, Liu YX, Jiang NJ, Qian ST, Huang XE, Wu JQ, He MF
Tissue & cell 2026 Feb;98:103185
Tissue & cell 2026 Feb;98:103185
Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance.
Zhao L, Du GL, Ruze A, Qi HZ, Zhang CS, Li QL, Deng AX, Zhao BH, Hu S, Gai MT, Gao XM
Journal of advanced research 2026 Feb;80:905-923
Journal of advanced research 2026 Feb;80:905-923
Diagnostic potential of neutrophil extracellular traps in ulcerative colitis: a gene-based predictive model.
Liang H, Xu Y, Zhang X, Han Z, Zhu J
Molecular and cellular biochemistry 2026 Feb;481(2):923-945
Molecular and cellular biochemistry 2026 Feb;481(2):923-945
Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal-induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney stones.
Su X, Yang Y, Xiang H, Dong C, Shi M, Wang Y, Zhou Q, Song Q, He Z, Jiang Q, Chen B, Wang Y, Xiong Y, Yang S
Particle and fibre toxicology 2026 Feb 12;23(1)
Particle and fibre toxicology 2026 Feb 12;23(1)
Tumor-Associated Macrophage-Derived CXCL1 Promotes Endometrial Cancer Progression Through the CXCR2/NF-κB Pathway.
Xia R, Qi D, Ji B, Dai Y, Kong X
Cancer science 2026 Apr;117(4):1026-1042
Cancer science 2026 Apr;117(4):1026-1042
Mechanistic Study of CD90-Positive Synovial Fibroblasts in the Invasion and Recurrence of Pigmented Villonodular Synovitis.
Kong L, Chen H, Zhang H, Zhang X, Chen J, Nie Y, Su Z, Lin L
Journal of inflammation research 2025;18:17129-17142
Journal of inflammation research 2025;18:17129-17142
Identification of shared biomarkers and potential therapeutic targets for antiphospholipid syndrome and recurrent miscarriage by integrated bioinformatics analysis and machine learning.
Zhang S, Zhang Y, Xu J, Hu W, Huang X, Chen X
Frontiers in medicine 2025;12:1639277
Frontiers in medicine 2025;12:1639277
Targeting HPK1 inhibits neutrophil responses to mitigate post-stroke lung and cerebral injuries.
Zhang T, Sun Y, Xia J, Fan H, Shi D, Wu Q, Huang M, Hou XY
EMBO molecular medicine 2025 May;17(5):1018-1040
EMBO molecular medicine 2025 May;17(5):1018-1040
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery.
Wang L, Guo Y, Chen B, Lu S, Yang J, Jin Y, Wang X, Sun X, Wang S, Wang B
Science advances 2025 Mar 7;11(10):eadv1661
Science advances 2025 Mar 7;11(10):eadv1661
CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance.
He T, Wang ZY, Xu B, Zhong CJ, Wang LN, Shi HC, Yang ZY, Zhou SQ, Li H, Hu B, Zhu XD, Shen YH, Zhou J, Fan J, Sun HC, Huang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2503009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2503009
DSG2 promotes pancreatic cancer stem cell maintenance via support of tumour and macrophage cellular cross-talk.
Wang F, Sun T, Wang N, Wei W, Mei Y, Yan Q
Cell death & disease 2025 Jul 4;16(1):492
Cell death & disease 2025 Jul 4;16(1):492
CXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain.
Chen K, Ye Q, Zhang Y, Qi Z, Huang Y, Lu W, Wang X, Wang Y, Cao L, Qiu S, Xu Y, Huang J, Xie J
Brain, behavior, and immunity 2025 Jan;123:1026-1041
Brain, behavior, and immunity 2025 Jan;123:1026-1041
CXCL6 Orchestrates Macrophage-Driven Inflammation in Diabetic Kidney Disease and Represents a Druggable Target.
Huang Y, Sun Y, Guo D, Lin H, Wu L, Zhou P, Wu D, Sun J, Zhou H, Hu Z, Peng H
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):812-834
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):812-834
Association between cytokines and progression-free survival in ovarian cancer following CRS/HIPEC treatment.
Chen CY, Wang TY, Liu JL, Ou YC, Lee LW, Hung CH, Lee CP, Lung J
Journal of ovarian research 2025 Jan 7;18(1):3
Journal of ovarian research 2025 Jan 7;18(1):3
Lichong decoction improves inflammatory microenvironment and alleviates fibrosis in uterine leiomyoma via targeting CXCL8.
Yang X, Chen Z, Qiu T, Liu Y, Ren H, Luo W, Zuo J, Li D
Journal of ethnopharmacology 2025 Jan 31;340:119276
Journal of ethnopharmacology 2025 Jan 31;340:119276
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.
Fan X, Yan Q, Xu W, Chen H, Xu Y, Lu S, Xu C, Tan J, Yu C, Lai Y, Fan M, Tao L, Li L, Shen W, Cheng H, Sun D
Journal of ethnopharmacology 2025 Feb 27;342:119361
Journal of ethnopharmacology 2025 Feb 27;342:119361
Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury.
Jiang Y, Jiang R, Xia Z, Guo M, Fu Y, Wang X, Xie J
Journal of nanobiotechnology 2025 Feb 22;23(1):134
Journal of nanobiotechnology 2025 Feb 22;23(1):134
RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer.
Hu S, Zhan N, Li J, Wang L, Liu Y, Jin K, Wang Y, Zhang J, Chen Y, Bai Y, Wang Y, Qi L, Liu S
Journal of translational medicine 2025 Feb 17;23(1):191
Journal of translational medicine 2025 Feb 17;23(1):191
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis.
Yang Q, Liu J, Liu Y, Liu S, Wei X, Yang Y, Zhang W, Zhang S, Zhang M, Liu B, Wang X, Zhu D
Materials today. Bio 2025 Aug;33:102009
Materials today. Bio 2025 Aug;33:102009
Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells.
Ruan GT, Zhu LC, Xie HL, Zhang HY, Song MM, Deng L, Shi HP
Cell death discovery 2025 Aug 21;11(1):395
Cell death discovery 2025 Aug 21;11(1):395
Langhans giant cells regulate cutaneous immune responses during mycobacterial infection through CXCL1/CXCL2 secretion.
Jiang Y, Jiang H, Zou Y, Wang Z, Gan T, Zeng R, Shi Y, Zhang W, Wang H
International immunopharmacology 2025 Apr 16;152:114447
International immunopharmacology 2025 Apr 16;152:114447
Concomitant NAFLD Facilitates Liver Metastases and PD-1-Refractory by Recruiting MDSCs via CXCL5/CXCR2 in Colorectal Cancer.
Yang Y, Chen Y, Liu Z, Chang Z, Sun Z, Zhao L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101351
Cellular and molecular gastroenterology and hepatology 2024;18(2):101351
Comprehensive Analysis of scRNA-Seq and Bulk RNA-Seq Reveals Transcriptional Signatures of Macrophages in Intrahepatic Cholestasis of Pregnancy.
Tang M, Xiong L, Cai J, Gong X, Fan L, Zhou X, Xing S, Yang X
Journal of inflammation research 2024;17:6863-6874
Journal of inflammation research 2024;17:6863-6874
Quercetin alleviates ulcerative colitis through inhibiting CXCL8-CXCR1/2 axis: a network and transcriptome analysis.
Jiang Z, Yan M, Qin Y, Liu Z, Duan Y, Wang Y, Zhang R, Lin W, Li Y, Xie T, Ke J
Frontiers in pharmacology 2024;15:1485255
Frontiers in pharmacology 2024;15:1485255
GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease.
Li C, Yang Y, Luo S, Qiu W, Wang X, Ge W
Cell death & disease 2024 Nov 11;15(11):815
Cell death & disease 2024 Nov 11;15(11):815
Osteocytes support bone metastasis of melanoma cells by CXCL5.
Jia Y, Zhang F, Meng X, Andreev D, Lyu P, Zhang W, Lai C, Schett G, Bozec A
Cancer letters 2024 May 28;590:216866
Cancer letters 2024 May 28;590:216866
Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
Cui S, Chen X, Li J, Wang W, Meng D, Zhu S, Shen S
Cell communication and signaling : CCS 2024 Mar 25;22(1):191
Cell communication and signaling : CCS 2024 Mar 25;22(1):191
CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance.
Wang Y, Ding W, Hao W, Gong L, Peng Y, Zhang J, Qian Z, Xu K, Cai W, Gao Y
iScience 2024 Jul 19;27(7):110224
iScience 2024 Jul 19;27(7):110224
Neuroprotective Effects of CXCR2 Antagonist SB332235 on Traumatic Brain Injury Through Suppressing NLRP3 Inflammasome.
Zhao K, Zhou X, Chen M, Gou L, Mei D, Gao C, Zhao S, Luo S, Wang X, Tan T, Zhang Y
Neurochemical research 2024 Jan;49(1):184-198
Neurochemical research 2024 Jan;49(1):184-198
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway.
Tatsuno R, Ichikawa J, Komohara Y, Pan C, Kawasaki T, Enomoto A, Aoki K, Hayakawa K, Iwata S, Jubashi T, Haro H
Cell death & disease 2024 Feb 1;15(2):108
Cell death & disease 2024 Feb 1;15(2):108
Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models.
Horn LA, Lind H, Fousek K, Qin H, Rajabian N, Angstadt S, Hsiao-Sanchez N, Medina-Enriquez MM, Kelly MD, Allen CT, Hammoudeh SM, Weigert R, Maeda DY, Zebala JA, Palena C
Journal of experimental & clinical cancer research : CR 2024 Dec 5;43(1):318
Journal of experimental & clinical cancer research : CR 2024 Dec 5;43(1):318
Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel finding.
Wei Y, Zheng X, Huang T, Zhong Y, Sun S, Wei X, Liu Q, Wang T, Zhao Z
PloS one 2023;18(8):e0288281
PloS one 2023;18(8):e0288281
CXCR2 antagonism attenuates neuroinflammation after subarachnoid hemorrhage.
Luo X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Sep;32(9):107266
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Sep;32(9):107266
Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8(+) T cell.
Xu F, Wang X, Huang Y, Zhang X, Sun W, Du Y, Xu Z, Kou H, Zhu S, Liu C, Wei X, Li X, Jiang Q, Xu Y
Cell reports 2023 Nov 28;42(11):113424
Cell reports 2023 Nov 28;42(11):113424
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
Luo S, Liao C, Zhang L, Ling C, Zhang X, Xie P, Su G, Chen Z, Zhang L, Lai T, Tang J
Cell reports 2023 Mar 28;42(3):112259
Cell reports 2023 Mar 28;42(3):112259
C-X-C Motif Chemokine 3 Promotes the Inflammatory Response of Microglia after Escherichia coli-Induced Meningitis.
Qu X, Dou B, Yang R, Tan C, Chen H, Wang X
International journal of molecular sciences 2023 Jun 21;24(13)
International journal of molecular sciences 2023 Jun 21;24(13)
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Ye S, Huang H, Xiao Y, Han X, Shi F, Luo W, Chen J, Ye Y, Zhao X, Huang W, Wang Y, Lai D, Liang G, Fu G
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.
Wang X, Xu F, Kou H, Zheng Y, Yang J, Xu Z, Fang Y, Sun W, Zhu S, Jiang Q, Wei X, Xu Y
Journal of extracellular vesicles 2023 Jul;12(7):e12342
Journal of extracellular vesicles 2023 Jul;12(7):e12342
Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.
Qin H, Zhuang W, Liu X, Wu J, Li S, Wang Y, Liu X, Chen C, Zhang H
Cell reports 2023 Jul 25;42(7):112745
Cell reports 2023 Jul 25;42(7):112745
Skewing cPLA(2)α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis.
Maus KD, Stephenson DJ, Macknight HP, Vu NT, Hoeferlin LA, Kim M, Diegelmann RF, Xie X, Chalfant CE
Science signaling 2023 Jul 11;16(793):eadd6527
Science signaling 2023 Jul 11;16(793):eadd6527
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
Yang N, Li M, Wu L, Song Y, Yu S, Wan Y, Cheng W, Yang B, Mou X, Yu H, Zheng J, Li X, Yu X
Journal of nanobiotechnology 2023 Jan 13;21(1):13
Journal of nanobiotechnology 2023 Jan 13;21(1):13
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells.
Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Sasaguri T
International immunopharmacology 2023 Apr;117:109913
International immunopharmacology 2023 Apr;117:109913
SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.
Tang L, Peng L, Liu H, Xiao T, Gu W, Yang H, Wang H, Chen P
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):214
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):214
Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.
Yao YZ, Liao ZK, Jiang S, Dong BQ, Luo LF, Miao F, Lei TC
Journal of dermatological science 2022 Nov;108(2):98-108
Journal of dermatological science 2022 Nov;108(2):98-108
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X, Zhang M
Frontiers in molecular biosciences 2021;8:717962
Frontiers in molecular biosciences 2021;8:717962
The CXCL1-CXCR2 Axis Mediates Tubular Injury in Diabetic Nephropathy Through the Regulation of the Inflammatory Response.
Tang H, Yang M, Liu Y, Liu H, Sun L, Song P
Frontiers in physiology 2021;12:782677
Frontiers in physiology 2021;12:782677
CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.
Zhang S, Ding J, Wang J, Yin T, Zhang Y, Yang J
Frontiers in immunology 2021;12:717483
Frontiers in immunology 2021;12:717483
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, Lin Y, Wang Z
Cell communication and signaling : CCS 2020 Mar 26;18(1):48
Cell communication and signaling : CCS 2020 Mar 26;18(1):48
Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.
Dominguez C, McCampbell KK, David JM, Palena C
JCI insight 2017 Nov 2;2(21)
JCI insight 2017 Nov 2;2(21)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 20634-1-AP(IL8RB antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of HepG2 cells, using IL8RB antibody 20634-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line