CXCR2

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Description

C-X-C motif chemokine receptor 2

Tissue specificity

Tissue enhanced (esophagus, lymphoid tissue)

Subcell location

Nucleoplasm, Plasma membrane, Microtubules, Mitotic spindle

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (218125289 - 218137251)

Ensembl ID

ENSG00000180871  (ver. 103.38)

Orthologs

-

UniProt

P25025

neXtProt

NX_P25025

Human splice variants

Protein structure