CXCR2

gene product
CD182, CMKAR2, IL8RB
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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912 antibodies from 45 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
289 antibodies
GeneTex
11 antibodies
R&D Systems
43 antibodies
Novus Biologicals
118 antibodies
Affinity Biosciences
3 antibodies
LifeSpan BioSciences, Inc.
94 antibodies
Invitrogen Antibodies
12 antibodies
OriGene
14 antibodies
Abnova Corporation
11 antibodies
NovoPro Bioscience Inc.
8 antibodies
Santa Cruz Biotechnology
1 antibody
Aviva Systems Biology
6 antibodies
Proteintech Group
1 antibody
Acris Antibodies GmbH
14 antibodies
Biorbyt
35 antibodies
Abbexa
4 antibodies
BioLegend
17 antibodies
Atlas Antibodies
2 antibodies
FabGennix
3 antibodies
Boster Biological Technology
1 antibody
Abbkine Scientific Co.Ltd.
3 antibodies
Enzo Life Sciences
2 antibodies
Creative Biolabs
64 antibodies
Abgent
6 antibodies
St John's Laboratory
5 antibodies
Antibodies.com
1 antibody
Exalpha Biologicals, Inc.
2 antibodies
MyBioSource
13 antibodies
NSJ Bioreagents
2 antibodies
Everest Biotech
1 antibody
ProSci
3 antibodies
Bioworld Technology, Inc
1 antibody
Signalway Antibody LLC
1 antibody
Miltenyi Biotec
14 antibodies
Abiocode, Inc.
1 antibody
Creative Diagnostics
7 antibodies
Sigma-Aldrich
2 antibodies
GenWay
3 antibodies
Abbiotec
1 antibody
United States Biological
57 antibodies