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- Antibody Data
- Antigen structure
- References [19]
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- Product number
- FAB2164P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse CXCR2/IL-8RB PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Stains mouse CXCR2-transfected cells but not CXCR1 transfectants.
- Reactivity
- Mouse
- Host
- Rat
- Antigen sequence
P35343- Isotype
- IgG
- Antibody clone number
- 242216
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2.
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer.
Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis.
Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes.
Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process.
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice.
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
IL-22 signaling contributes to West Nile encephalitis pathogenesis.
MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.
α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.
CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis.
Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokines.
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Stimulation of the molecule 4-1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytes.
Duffy antigen modifies the chemokine response in human endotoxemia.
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.
Brennan FH, Jogia T, Gillespie ER, Blomster LV, Li XX, Nowlan B, Williams GM, Jacobson E, Osborne GW, Meunier FA, Taylor SM, Campbell KE, MacDonald KP, Levesque JP, Woodruff TM, Ruitenberg MJ
JCI insight 2019 May 2;4(9)
JCI insight 2019 May 2;4(9)
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, Xu L, Ramadan M, Brown J, Turnquist HR, Billiar TR
PLoS medicine 2017 Jul;14(7):e1002365
PLoS medicine 2017 Jul;14(7):e1002365
CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer.
Wang D, Sun H, Wei J, Cen B, DuBois RN
Cancer research 2017 Jul 1;77(13):3655-3665
Cancer research 2017 Jul 1;77(13):3655-3665
Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis.
Lee WB, Yan JJ, Kang JS, Zhang Q, Choi WY, Kim LK, Kim YJ
Scientific reports 2017 Jan 23;7:41106
Scientific reports 2017 Jan 23;7:41106
Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes.
Wu X, Dayanand KK, Thylur RP, Norbury CC, Gowda DC
The Journal of biological chemistry 2017 Aug 18;292(33):13615-13634
The Journal of biological chemistry 2017 Aug 18;292(33):13615-13634
Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process.
Bueno-Silva B, Franchin M, Alves CF, Denny C, Colón DF, Cunha TM, Alencar SM, Napimoga MH, Rosalen PL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 1;23(13):1583-1590
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 1;23(13):1583-1590
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration.
Li Y, Huang J, Foley NM, Xu Y, Li YP, Pan J, Redmond HP, Wang JH, Wang J
Scientific reports 2016 Aug 12;6:31284
Scientific reports 2016 Aug 12;6:31284
CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice.
Citro A, Valle A, Cantarelli E, Mercalli A, Pellegrini S, Liberati D, Daffonchio L, Kastsiuchenka O, Ruffini PA, Battaglia M, Allegretti M, Piemonti L
Diabetes 2015 Apr;64(4):1329-40
Diabetes 2015 Apr;64(4):1329-40
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
Guabiraba R, Besnard AG, Menezes GB, Secher T, Jabir MS, Amaral SS, Braun H, Lima-Junior RC, Ribeiro RA, Cunha FQ, Teixeira MM, Beyaert R, Graham GJ, Liew FY
Mucosal immunology 2014 Sep;7(5):1079-93
Mucosal immunology 2014 Sep;7(5):1079-93
IL-22 signaling contributes to West Nile encephalitis pathogenesis.
Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E
PloS one 2012;7(8):e44153
PloS one 2012;7(8):e44153
MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.
Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, Espigol-Frigole G, Wang S, Tosato G
Haematologica 2012 Jun;97(6):818-26
Haematologica 2012 Jun;97(6):818-26
α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.
Spiller F, Carlos D, Souto FO, de Freitas A, Soares FS, Vieira SM, Paula FJ, Alves-Filho JC, Cunha FQ
Diabetes 2012 Jun;61(6):1584-91
Diabetes 2012 Jun;61(6):1584-91
CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis.
Ishii M, Asano K, Namkoong H, Tasaka S, Mizoguchi K, Asami T, Kamata H, Kimizuka Y, Fujiwara H, Funatsu Y, Kagawa S, Miyata J, Ishii K, Nakamura M, Hirai H, Nagata K, Kunkel SL, Hasegawa N, Betsuyaku T
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5655-64
Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 1;188(11):5655-64
Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokines.
Zarbock A, Bishop J, Müller H, Schmolke M, Buschmann K, Van Aken H, Singbartl K
American journal of physiology. Lung cellular and molecular physiology 2010 Mar;298(3):L462-71
American journal of physiology. Lung cellular and molecular physiology 2010 Mar;298(3):L462-71
Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Chou RC, Kim ND, Sadik CD, Seung E, Lan Y, Byrne MH, Haribabu B, Iwakura Y, Luster AD
Immunity 2010 Aug 27;33(2):266-78
Immunity 2010 Aug 27;33(2):266-78
Stimulation of the molecule 4-1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytes.
Lee SC, Ju SA, Sung BH, Heo SK, Cho HR, Lee EA, Kim JD, Lee IH, Park SM, Nguyen QT, Suh JH, Kim BS
Infection and immunity 2009 May;77(5):2168-76
Infection and immunity 2009 May;77(5):2168-76
Duffy antigen modifies the chemokine response in human endotoxemia.
Mayr FB, Spiel AO, Leitner JM, Firbas C, Kliegel T, Jilma-Stohlawetz P, Derendorf H, Jilma B
Critical care medicine 2008 Jan;36(1):159-65
Critical care medicine 2008 Jan;36(1):159-65
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ
Blood 2007 Apr 1;109(7):2936-43
Blood 2007 Apr 1;109(7):2936-43
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.
Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS
Blood 2006 Dec 1;108(12):3682-90
Blood 2006 Dec 1;108(12):3682-90
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CXCR2/IL-8 RB in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse Gr-1/Ly-6G APC-conjugated Monoclonal Antibody (Catalog # FAB1037A) and either (A) Rat Anti-Mouse CXCR2/IL-8 RB PE-conjugated Monoclonal Antibody (Catalog # FAB2164P) or (B) Rat IgG1 Phycoerythrin Isotype Control (Catalog # IC005P). View our protocol for Staining Membrane-associated Proteins.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CXCR2/IL-8 RB in HEK293 Human Cell Line Transfected with Mouse CXCR2/IL-8 RB and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) mouse CXCR2/IL-8 RB or (B) mouse CXCR1/IL-8 RA and eGFP was stained with Rat Anti-Mouse CXCR2/IL-8 RB PE-conjugated Monoclonal Antibody (Catalog # FAB2164P). Quadrant markers were set based on control antibody staining (Catalog # IC005P). View our protocol for Staining Membrane-associated Proteins.
