INPP5D

gene product
hp51CN, SHIP, SHIP1
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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491 antibodies from 39 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Santa Cruz Biotechnology
1 antibody
Novus Biologicals
39 antibodies
antibodies-online
200 antibodies
Cell Signaling Technology, Inc
5 antibodies
Invitrogen Antibodies
10 antibodies
Boster Biological Technology
4 antibodies
Atlas Antibodies
1 antibody
Proteintech Group
1 antibody
Abnova Corporation
3 antibodies
NSJ Bioreagents
1 antibody
R&D Systems
1 antibody
LifeSpan BioSciences, Inc.
41 antibodies
GeneTex
4 antibodies
Affinity Biosciences
4 antibodies
NovoPro Bioscience Inc.
4 antibodies
Antibodies.com
2 antibodies
Biorbyt
24 antibodies
Acris Antibodies GmbH
12 antibodies
Aviva Systems Biology
5 antibodies
Arigo
4 antibodies
OriGene
11 antibodies
BioLegend
7 antibodies
Abbkine Scientific Co.Ltd.
3 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
2 antibodies
Miltenyi Biotec
4 antibodies
Spring Bioscience
4 antibodies
St John's Laboratory
4 antibodies
MyBioSource
11 antibodies
STEMCELL Technologies Inc
4 antibodies
RabMAbs
1 antibody
Abbexa
2 antibodies
EMD Millipore
2 antibodies
United States Biological
39 antibodies
ProSci
2 antibodies
Creative Diagnostics
1 antibody
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
1 antibody