DLG1

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]

Description

Discs large MAGUK scaffold protein 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (197042560 - 197299330)

Ensembl ID

ENSG00000075711  (ver. 103.38)

Orthologs

Mouse Dlg1: ENSMUSG00000022770

UniProt

Q12959

neXtProt

NX_Q12959

Human splice variants
Mouse splice variants

Protein structure