Tissue expression
Cell line expression
DLG1
gene productdJ1061C18.1.1, DLGH1, hdlg, SAP-97, SAP97
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]
- Description
- Discs large MAGUK scaffold protein 1
- Tissue specificity
- Low tissue specificity
- Subcell location
- Vesicles, Plasma membrane
- Predicted location
- Intracellular
- Protein family
- Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters
- Chromosome
- 3:q29 (197042560 - 197299330)
- Ensembl ID
- ENSG00000075711 (ver. 103.38)
- Orthologs
- Mouse Dlg1: ENSMUSG00000022770
- UniProt
- Q12959
- neXtProt
- NX_Q12959
Human splice variants
Mouse splice variants
Ensembl | UniProt | RefSeq | Entrez |
---|---|---|---|
ENSMUST00000023454 ENSMUSP00000023454 |
NP_001239363.1 NP_001239363 | Dlg1 13383 | |
ENSMUST00000064477 ENSMUSP00000064280 |
Q811D0.185 Q811D0 | NP_031888.2 NP_031888 NP_001239362.1 NP_001239362 | Dlg1 13383 |
ENSMUST00000100001 ENSMUSP00000097581 |
Q811D0.185 Q811D0 | Dlg1 13383 | |
ENSMUST00000115196 ENSMUSP00000110850 |
NP_001239365.1 NP_001239365 NP_001344210.1 NP_001344210 | Dlg1 13383 | |
ENSMUST00000115201 ENSMUSP00000110855 |
NP_001344211.1 NP_001344211 | Dlg1 13383 | |
ENSMUST00000115205 ENSMUSP00000110859 |
Q811D0.185 Q811D0 | NP_001239364.1 NP_001239364 | Dlg1 13383 |
ENSMUST00000130920 ENSMUSP00000138804 |
Dlg1 13383 | ||
ENSMUST00000131136 ENSMUSP00000115954 |
Dlg1 13383 | ||
ENSMUST00000132176 ENSMUSP00000138782 |
Dlg1 13383 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.