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- Antigen structure
- References [413]
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- Product number
- 13880-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13880-1-AP, RRID:AB_2722780
- Product name
- Aggrecan antibody
- Antibody type
- Polyclonal
- Description
- Aggrecan antibody (Cat. #13880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PDGFRα-positive mesenchymal stem/stromal cells contribute to autonomous vascular formation through in-body tissue architecture.
Pharmacodynamic evaluation and mechanism study of cord blood nucleated cell extract in the treatment of rheumatoid arthritis.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair.
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing.
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Collagenesis orchestrates mechanoadaptive development and homeostasis of intervertebral discs.
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
CILP Inhibits hyaline cartilage fibrosis and chondrocyte ferroptosis via keap1-Nrf2 axis in early osteoarthritis exercise therapy.
Long-term mechanical loading aggravates osteoarthritis through a pro-apoptotic inflammatory microenvironment.
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration.
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Chondrocyte-Targeted Nanoparticles Loaded with N-Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance.
Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Dopamine-functionalized bioinspired pre-chondrogenic hydrogel for cell-free cartilage regeneration.
Aldh1L1 Lineage Cells Contribute to the Functional Heterogeneity Within the Cells in Glial Scars After Spinal Cord Injury Through YAP Signaling.
Biomimetic Multilayered Gas-Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration.
Bilayer Hydrogel Scaffold with Directional Micro-Channels and Mechanical Gradient to Promote Osteochondral Repair.
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
IL-33/ST2 axis delays disc degeneration through PI3K/AKT-dependent regulation of nucleus pulposus cell proliferation and apoptosis.
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Mettl1-mediated m(7)G modification of Fgfr2 regulates osteogenic and chondrogenic differentiation of mesenchymal stem cells.
Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis.
Pelubiprofen and Shinbaro: a therapeutic approach for osteoarthritis in a murine medial meniscus destabilization model.
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway.
A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy.
Chronic cervical instability in mice and rats: a reproducible model to simulate human intervertebral disc degeneration.
ZIF-8-loaded decellularized porcine annulus fibrosus bioadhesive enhances rotator cuff tendon-to-bone healing in a rat model.
IL-6 signaling is required for the development and regeneration of ear cartilage in microtia.
Injectable ion-coordinated double-network conductive hydrogel for spinal cord injury repair.
Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence.
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway.
3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.
Mitochondrial electron transfer chain activation in atrophic Muscle: Implications for calcium signaling and chondrocyte apoptosis in osteoarthritis.
Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy.
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice.
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1(+) tendon sheath progenitors.
Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype.
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Rabbits as preclinical animal models of cam morphology: proof of concept.
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model.
Glycolytic Metabolite 3-Phosphoglycerate Induced by Inflammation Inhibits Chondrocyte Survival.
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
Vitamins D and K jointly protect against osteoarthritis via regulating OSCAR during osteoclastogenesis.
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study.
Injectable visible light cross-linking aldehyde-based methacrylated hyaluronic acid hydrogels enhance cartilage repair via improved BMSC homing and chondrogenic differentiation.
WTAP improves chondrocyte loss and dysfunctions to ameliorate osteoarthritis through mediating the mA methylation and mRNA stability of IL-33.
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
A light-cured injectable composite hydrogel based on chitosan and decellularized matrix modulates stem cell aggregation behavior for accelerating cartilage defect repair.
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Microalgae-Derived Extracellular Vesicles Synergize with Herbal Hydrogel for Energy Homeostasis in Osteoarthritis Treatment.
Recapitulation of endochondral ossification by hPSC-derived SOX9(+) sclerotomal progenitors.
Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation.
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Metformin-Loaded Tannic Acid Nanoparticles Attenuate Osteoarthritis by Promoting Chondrocyte Mitochondria Homeostasis Based on Mitocytosis.
Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
The phenotypic characterization of mouse floxed Fam20b chondrocytes, a novel articular cartilage-derived cell line with differentiation potential.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
FSTL1 Can Be a Promising Target in TMJ Osteoarthritis via Regulating Chondrocyte Mitophagy and Apoptosis.
RETRACTED ARTICLE: Administration of methylprednisolone do not affect the spinal scar component of spinal cord injury.
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.
Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation.
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Obesity hinders the efficacy of adipose-derived stem cells for knee osteoarthritis by reducing the proportion of DPP4+ stem cells.
Three-Dimensional-Printed Ordered Bredigite Scaffolds with Dual Bioactivities Promote Osteochondral Regeneration.
Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration.
Unveiling the therapeutic potential of phenolic compounds from Boletus edulis in osteoarthritis treatment.
Bioengineered chondrocyte-products from human induced pluripotent stem cells are useful for repairing articular cartilage injury in minipig model.
Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy.
Electrohydrodynamic-Printed Dual-Triphase Microfibrous Scaffolds Reshaping the Lipidomic Profile for Enthesis Healing in a Rat Rotator Cuff Repair Model.
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.
Tree shrew as a new animal model for musculoskeletal disorders and aging.
Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.
Cpeb1 remodels cell type-specific translational program to promote fear extinction.
Cellular senescence contributes to spontaneous repair of the rat meniscus.
Effect of 3D-Printed Polycaprolactone Scaffold With Powdery/Smooth Micromorphology on Local Immune Environments.
Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis.
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies.
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
DDRGK1 preserves intervertebral disc development through ufmylation.
In Situ Supply and Anchoring of Glycosaminoglycan by Dual-Modified Hydrogel Loaded with Glycoengineered Stem Cells for Attenuating Disc Degeneration.
Dual-functional ROS-responsive hydrogel alleviates temporomandibular joint osteoarthritis by enhancing cartilage repair and mitigating inflammation.
Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage.
Pure platelet-rich plasma delays intervertebral disc degeneration by activating SIRT1-mediated autophagy in nucleus pulposus cells.
Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis.
Deciphering cartilage neuro-immune interactions and innervation profile through 3D engineered osteoarthritic micropathophysiological system.
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Fullerol Initiates Stem Cell-Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling.
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation.
FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression.
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Custom-Made Ce-Mn Bimetallic Nanozyme for the Treatment of Intervertebral Disc Degeneration by Inhibiting Oxidative Stress and Modulating Macrophage M1/M2 Polarization.
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis.
Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration.
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Promoting chondrogenesis by targeted delivery to the degenerating cartilage in early treatment of osteoarthritis.
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
An anti-senescence hydrogel with pH-responsive drug release for mitigating intervertebral disc degeneration and low back pain.
Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy.
Systematic analysis of lysine lactylation in nucleus pulposus cells.
Efficient Production of Chondrocyte Particles from Human iPSC-Derived Chondroprogenitors Using a Plate-Based Cell Self-Aggregation Technique.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
An integrated multi-omics analysis reveals osteokines involved in global regulation.
siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration.
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis.
LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels.
Platelet-rich plasma alleviates knee arthritis in rats by inhibiting p65.
Injectable Ozone-Rich Nanocomposite Hydrogel Loaded with D-Mannose for Anti-Inflammatory and Cartilage Protection in Osteoarthritis Treatment.
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
Biofabrication of Tissue-Engineered Cartilage Constructs Through Faraday Wave Bioassembly of Cell-Laden Gelatin Microcarriers.
A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration.
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
JD-312 - A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression.
microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Lei's formula attenuates osteoarthritis mediated by suppression of chondrocyte senescence via the mTOR axis: in vitro and in vivo experiments.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
Tissue-engineered collagen matrix loaded with rat adipose-derived stem cells/human amniotic mesenchymal stem cells for rotator cuff tendon-bone repair.
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Ultra-Long-Term Anti-Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage.
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
High-Intensity Interval Training Increases Osteoarthritis-Associated Pain-Sensitive Threshold Through Reduction of Perineuronal Nets of the Medial Prefrontal Cortex in Rats.
YAP1 exacerbates pyroptosis and senescence in nucleus pulposus cells by promoting BNIP3-mediated mitophagy.
T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy.
Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration.
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect.
PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Raphanus sativus Linne Protects Human Nucleus Pulposus Cells against H(2)O(2)-Induced Damage by Inhibiting TREM2.
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Role of Galectin-3 in intervertebral disc degeneration: an experimental study.
Age-Related Gene and Protein Expression in Mouse Mandibular Condyle Analyzed by Cap Analysis of Gene Expression and Immunohistochemistry.
Immunohistochemical characterization of the mandibular condyle for type I and II collagen, aggrecan, MMP-9, and MMP-13 in MMP-2-deficient mice.
Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion.
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Liquid platelet-rich fibrin produced via horizontal centrifugation decreases the inflammatory response and promotes chondrocyte regeneration in vitro.
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
Nano-elemental selenium particle developed via supramolecular self-assembly of chondroitin sulfate A and Na(2)SeO(3) to repair cartilage lesions.
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
Low-intensity pulsed ultrasound irradiation attenuates collagen degradation of articular cartilage in early osteoarthritis-like model mice.
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Traditional Chinese Medicine formula Bu-Shen-Huo-Xue-Fang (BSHXF) protects nucleus pulposus cells against the inflammatory and oxidative stress-induced degenerative changes.
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration.
Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration.
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis.
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Enhanced Cell Penetration and Pluripotency Maintenance of hiPSCs in 3D Natural Chitosan Scaffolds.
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice.
The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
GPRC5B protects osteoarthritis by regulation of autophagy signaling.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension.
Unravelling diagnostic clusters and immune landscapes of cuproptosis patterns in intervertebral disc degeneration through dry and wet experiments.
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9.
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2.
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/β-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2.
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.
A three-dimensional (3D), serum-free, Collagen Type I system for chondrogenesis of canine bone marrow-derived multipotent stromal cells (cMSCs).
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism.
Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
Chemically crosslinked hyaluronic acid-chitosan hydrogel for application on cartilage regeneration.
MCP‑1/CCR2 axis inhibits the chondrogenic differentiation of human nucleus pulposus mesenchymal stem cells.
Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Scavenging of reactive oxygen species can adjust the differentiation of tendon stem cells and progenitor cells and prevent ectopic calcification in tendinopathy.
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.
Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism.
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3.
Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model.
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.
MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad.
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.
Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture.
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Cadherin-11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure.
Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monocarboxylate Transporter 4.
A plant-derived natural photosynthetic system for improving cell anabolism.
Bioprinted living tissue constructs with layer-specific, growth factor-loaded microspheres for improved enthesis healing of a rotator cuff.
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells.
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
DDIT3/CHOP mediates the inhibitory effect of ER stress on chondrocyte differentiation by AMPKα-SIRT1 pathway.
Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration.
Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12/AKT/β-catenin axis.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.
Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease.
Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration.
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.
AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Fabrication of 3D-Printed Interpenetrating Hydrogel Scaffolds for Promoting Chondrogenic Differentiation.
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.
In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
SIRT4 suppresses the inflammatory response and oxidative stress in osteoarthritis.
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.
miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.
CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration.
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis.
Knockdown of SGK1 alleviates the IL-1β-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes.
An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration.
Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration.
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration.
Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration.
Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits.
Normobaric oxygen therapy increases cartilage survival ratio in auricular composite grafting in rat models.
Leukemia inhibitory factor promotes extracellular matrix synthesis in degenerative nucleus pulposus cells via MAPK-ERK1/2 signaling pathway.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress.
Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin.
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells.
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Ancient origin of lubricated joints in bony vertebrates.
Morikawa S, Yoda M, Ouchi T, Yasui T, Fukuda K, Sugimoto M, Harada R, Matsumoto T, Mabuchi Y, Tsuji O, Nagoshi N, Kase Y, Okano H, Kitagawa Y, Nakamura M, Nakagawa T, Nakayama Y
PloS one 2026;21(4):e0347197
PloS one 2026;21(4):e0347197
Pharmacodynamic evaluation and mechanism study of cord blood nucleated cell extract in the treatment of rheumatoid arthritis.
Guo R, Yang J, Zhang H, Zhang Y, Hou S, Zhang L, Han J, Yang W, Liu N, Qiu L
Clinical rheumatology 2026 May;45(5):2615-2626
Clinical rheumatology 2026 May;45(5):2615-2626
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair.
Chen S, Luo M, Chen S, Chen D, Zeng L, Shangguan L, Sun Z, Li G, Ding W, Tang W, He Q
Cell stem cell 2026 May 7;33(5):837-852.e8
Cell stem cell 2026 May 7;33(5):837-852.e8
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing.
Wu D, Zhu D, Zhou X, Li G, Zhang X, Ma L, Liang H, Tong B, Lei J, Wang H, Ke W, Feng X, Wang K, Tan L, Shi Y, Yang C, Wang B
ACS nano 2026 Mar 31;20(12):9619-9637
ACS nano 2026 Mar 31;20(12):9619-9637
Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.
Xia C, Dai Z, Wang Y, Yu J, Wang Z, Huang Z, Pan K, Yang K, Chen Y, Zhong P, Gu C, Fan S, Lin X, Chen P
Nature communications 2026 Mar 31;17(1)
Nature communications 2026 Mar 31;17(1)
Collagenesis orchestrates mechanoadaptive development and homeostasis of intervertebral discs.
He J, Huang S, Li Y, Wang Y, Yan P, Hu O, Lin P, Jin H, Zhu J, Zhang L, Liu Y, Qin Q, Guo Y, Zheng X, Xie Y, Chen L, Lan Y, Liu B, Liu P, Gan Y
Cell reports 2026 Mar 24;45(3):117076
Cell reports 2026 Mar 24;45(3):117076
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Qin W, Wei J, Li F, Wang L, Zhang Q, Chen J, Lu P, Long T, Liu A, Cao J, Deng Y, Zhang H, Chen D, Cui J, Zhao W
Cell reports 2026 Mar 24;45(3):116993
Cell reports 2026 Mar 24;45(3):116993
CILP Inhibits hyaline cartilage fibrosis and chondrocyte ferroptosis via keap1-Nrf2 axis in early osteoarthritis exercise therapy.
Jia S, Hu Z, Li Z, Zhang W, Chen L, Niu C, Zhao Z, Sun Y, Yao G, Wang Y, Yang Y
Cellular and molecular life sciences : CMLS 2026 Mar 23;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 23;83(1)
Long-term mechanical loading aggravates osteoarthritis through a pro-apoptotic inflammatory microenvironment.
Shen S, Fang T, Dong J, Li J, Xu M, Wu J, Zhang J, Li J, Liu W, Zhou W, Li X
Journal of biomedical research 2026 Mar 19;40(2):134-146
Journal of biomedical research 2026 Mar 19;40(2):134-146
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Zhang H, Liu Y, Zhang S, Wang Z, Zhang X, Zhang Y, Zhang J, Liang S, Li C, Su M, Tian Z, Luo L
Journal of nanobiotechnology 2026 Mar 16;24(1)
Journal of nanobiotechnology 2026 Mar 16;24(1)
Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration.
Dou Y, Zhang F, Jiang Z, Mao J, Guo H, Li Y, Wang W, Meng X, Fan Q, Wang J, Jiang D
Bioactive materials 2026 Jun;60:113-127
Bioactive materials 2026 Jun;60:113-127
Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation.
Niu Z, Fan Y, Chen J, Ji L, Tong Y, Yao L, Ding S, Xu H, Chen J, Zhang Q, Zhao C, Chen J, Bi Q, Xia C
Materials today. Bio 2026 Jun;38:103038
Materials today. Bio 2026 Jun;38:103038
Chondrocyte-Targeted Nanoparticles Loaded with N-Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance.
Wang S, Zhang F, Zhou X, Yang J, Li Z, Li S, Lu Q, Sun H, Liu P
Small science 2026 Jan;6(1):e202500440
Small science 2026 Jan;6(1):e202500440
Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells.
Ren L, Li C, Sun J, Zheng Y, Jiao Y, Zheng J, Zhang F, Lin Y, Wu W, Cao P
The FEBS journal 2026 Jan;293(1):295-317
The FEBS journal 2026 Jan;293(1):295-317
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
Microenvironment-targeted strontium delivery system reshapes redox homeostasis to halt degenerative cascades in intervertebral discs.
Cheng H, A C, Shu Z, Zhao H, Wang L, Huang C, Li W, Fang X, Wu H, Bao X, Fang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114449
Dopamine-functionalized bioinspired pre-chondrogenic hydrogel for cell-free cartilage regeneration.
Zhu Q, Zhu L, Lang J, Zhu J, Chen D, Huang Y, Zhang J, Wu X, Hu J, Ji J, Yang Q, Du Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114407
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114407
Aldh1L1 Lineage Cells Contribute to the Functional Heterogeneity Within the Cells in Glial Scars After Spinal Cord Injury Through YAP Signaling.
Zhu Z, Luo X, Lin X, Zheng T, Fan Z, Wu Y, Jia M, Zhang W, Lian J, Zhou J, Fang Z, Wang Y, Teng H, Huang Z
Glia 2026 Feb;74(2):e70092
Glia 2026 Feb;74(2):e70092
Biomimetic Multilayered Gas-Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration.
Chen Y, Li Y, Wei Z, Du L, Qian M, Wang J, Mo X, Deng Z, Ye X, Yu J
Advanced healthcare materials 2026 Feb;15(7):e02833
Advanced healthcare materials 2026 Feb;15(7):e02833
Bilayer Hydrogel Scaffold with Directional Micro-Channels and Mechanical Gradient to Promote Osteochondral Repair.
Liu Y, Xu W, Zhao D, Li Y, Guo Z, Yuan L, Gao W, Han D, Ye C
Advanced healthcare materials 2026 Feb;15(6):e03547
Advanced healthcare materials 2026 Feb;15(6):e03547
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Lin Z, Wu C, Du Y, Zhao D, Li Y, Wang L, Kang Y, Li Z, Zuo R, Cui W, Zhao J
Advanced healthcare materials 2026 Feb;15(5):e04034
Advanced healthcare materials 2026 Feb;15(5):e04034
Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway.
Ni J, Zhou H, Shen K, Xu H, Wang J, Liu J, Liu F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Lyu G, Gao Z, Cao Z, Zhou Q, Chen Y, Yang S, Liang H, Lu X, Li S, Wang X, Sun S, Gao X, Zhou Y, Wu A, Zhou X, Wang X
Journal of nanobiotechnology 2026 Feb 19;24(1)
Journal of nanobiotechnology 2026 Feb 19;24(1)
IL-33/ST2 axis delays disc degeneration through PI3K/AKT-dependent regulation of nucleus pulposus cell proliferation and apoptosis.
Wang H, Zhou P, Chen Y, Li Y, Liu J
Cellular signalling 2026 Aug;144:112548
Cellular signalling 2026 Aug;144:112548
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Zhu Y, Leng P, Liang W, Xu W, Liang H, Yang Y, Si X, Liu X, Yang X, Shi C, Liu M
International journal of biological macromolecules 2026 Apr;358:151622
International journal of biological macromolecules 2026 Apr;358:151622
Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.
Luo J, Yu T, Hu P, Liu J
Non-coding RNA research 2026 Apr;17:76-89
Non-coding RNA research 2026 Apr;17:76-89
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
Xu H, Geng W, Du Z, Du Y, Wu D, Tong B, Liang H, Zhou X, Ou Z, Wei J, Wang K, Song Y, Hua W, Xu Y, Ke W, Wang B, Yang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Li S, Luo D, Liang Y, Zou Y, Pu H, Zheng M, Wang Y, Sun X, Zhu H, Zhu Y, Zhao L, Xiao J
International journal of biological sciences 2025;21(4):1666-1685
International journal of biological sciences 2025;21(4):1666-1685
Mettl1-mediated m(7)G modification of Fgfr2 regulates osteogenic and chondrogenic differentiation of mesenchymal stem cells.
Li Q, Zhang Y, Ji P, Zhang Y, Jiang J, Jin J, Yuan Z, Tian G, Cai M, Feng P, Wu Y, Liu W, Wang P
International journal of biological sciences 2025;21(13):5704-5724
International journal of biological sciences 2025;21(13):5704-5724
Changes in Nucleus Pulposus Cell Atlas and the Role of SPP1 During Intervertebral Disc Degeneration: Single-Cell Sequencing Analysis.
Liu C, Jiao K, Li X, Deng Z, Wang S, Cheng Y, Li M, Zhou X, Wei X
Mediators of inflammation 2025;2025:5593429
Mediators of inflammation 2025;2025:5593429
Pelubiprofen and Shinbaro: a therapeutic approach for osteoarthritis in a murine medial meniscus destabilization model.
Hong JY, Kim H, Kim H, Jeon WJ, Yeo C, Lee J, Lee YJ, Ha IH
Frontiers in pharmacology 2025;16:1665393
Frontiers in pharmacology 2025;16:1665393
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis.
Deng J, Gu J, Gong X, Tang H, Cai Y, Yang Y, Dong S, Zhao C
Frontiers in immunology 2025;16:1630253
Frontiers in immunology 2025;16:1630253
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway.
Wang S, Zhou X, Zhang F, Zhai H, Zhang Y, Guo Y
Frontiers in immunology 2025;16:1577234
Frontiers in immunology 2025;16:1577234
A strategy targeting ferroptosis for mitochondrial reprogramming and intervertebral disc degeneration therapy.
Wu T, Teng Y, Song D, Yang Y, Shen H, Sun X, Chen R, Zhao L, Zhong X, Yan Q, Niu J, Ge J, Cheng L, Zou J
Theranostics 2025;15(17):9159-9178
Theranostics 2025;15(17):9159-9178
Chronic cervical instability in mice and rats: a reproducible model to simulate human intervertebral disc degeneration.
Tu K, Tan J, Zeng G, Xu F, Liao D, Lu W, Zhao K, Chen Z, Zhou B, Dai X
PeerJ 2025;13:e20465
PeerJ 2025;13:e20465
ZIF-8-loaded decellularized porcine annulus fibrosus bioadhesive enhances rotator cuff tendon-to-bone healing in a rat model.
Jiang X, Xu H, Sun X, Yang X, Xia Y, Xue W, He Y
Frontiers in bioengineering and biotechnology 2025;13:1642818
Frontiers in bioengineering and biotechnology 2025;13:1642818
IL-6 signaling is required for the development and regeneration of ear cartilage in microtia.
Luan W, Fan S, Jiang H, Jiang D, Yang J, He L
Frontiers in cell and developmental biology 2025;13:1625058
Frontiers in cell and developmental biology 2025;13:1625058
Injectable ion-coordinated double-network conductive hydrogel for spinal cord injury repair.
Yu H, Liu F, Hu Y, Wan W, Liu Q, Zhou S, Zhang L, Li L, Huang F
Frontiers in bioengineering and biotechnology 2025;13:1618680
Frontiers in bioengineering and biotechnology 2025;13:1618680
Injectable hydrogel loaded with exosomes from hypoxic umbilical cord-derived mesenchymal stem cells alleviates intervertebral disc degeneration by reversing nucleus pulposus cell senescence.
Zhao X, Shi Y, Sun Z, Duan W, Chang L, Xu B, Lai K, Zhang J, Tian B, Tao W, Mi Z, Zhang M, Yang W, Luo Z, Ye Z
Regenerative biomaterials 2025;12:rbaf039
Regenerative biomaterials 2025;12:rbaf039
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
Jiang Z, Li J, Shi M, Li Y, Sun N, Xi K, Li X, Zhao D, Leng X, Zhou Z, Dong H
Redox biology 2025 Sep;85:103757
Redox biology 2025 Sep;85:103757
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Ren S, Zeng W, Du Z, Dai J, Li X, Wang H, Liu Y, Li R, Liu J
Journal of natural medicines 2025 Sep;79(5):1030-1043
Journal of natural medicines 2025 Sep;79(5):1030-1043
Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway.
Jin X, Wang X, Xu S, Xu N, Wang Z, Hu C, Liu W, Zhang Z, Liu X, Fan J, Jiang R, Wu R, Lv Z, Shi D
Journal of orthopaedic translation 2025 Sep;54:101-114
Journal of orthopaedic translation 2025 Sep;54:101-114
3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.
Lou W, Qiu X, Qin Y, Lu Y, Cao Y, Lu H
Bioactive materials 2025 Sep;51:231-256
Bioactive materials 2025 Sep;51:231-256
Mitochondrial electron transfer chain activation in atrophic Muscle: Implications for calcium signaling and chondrocyte apoptosis in osteoarthritis.
Li A, Pang T, Yang J, Wang Y, Dong L, Zhou Z, Li Y, Leng X, Dong H, Wang Y
Free radical biology & medicine 2025 Sep;237:285-299
Free radical biology & medicine 2025 Sep;237:285-299
Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy.
Hu C, Ma J, Chen X, Chen Y, Song Y, Tang Q, He X, Wang Y, Gao H, Zhang J
Science advances 2025 Sep 5;11(36):eadu5245
Science advances 2025 Sep 5;11(36):eadu5245
Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice.
Suo J, Li L, Tan W, Yin X, Wang J, Shao R, Sun S, Guo SK, Feng J, Gao BQ, Wang Y, Wei MY, Wang L, Feng H, Gao X, Hu P, Zheng X, Chen LL, Lei G, Huang Y, Zou W
Nature communications 2025 Sep 26;16(1):8480
Nature communications 2025 Sep 26;16(1):8480
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration.
Wang S, Zhai Y, Liu M, Cheng Z, Zhang J, Zhang H, Wang H, Hu Y, Li C, Luo Z
Acta biomaterialia 2025 Sep 1;203:229-244
Acta biomaterialia 2025 Sep 1;203:229-244
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1(+) tendon sheath progenitors.
Chen L, Peng C, Chai L, Zhang R, Zhu C, Wang H, Cheng Q, Yan Y, Shen C, Zheng H, Yang J, Fan H, Kan C
The EMBO journal 2025 Oct;44(20):5890-5917
The EMBO journal 2025 Oct;44(20):5890-5917
Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype.
Wu X, Wang H, Li C, Zhu Y, Wang Q, Zhang T, Fu Y, He A
Materials today. Bio 2025 Oct;34:102203
Materials today. Bio 2025 Oct;34:102203
Seeds-and-soil inspired hydrogel microspheres: A dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration.
Yang Y, Guo J, Cao H, Tian X, Shen H, Niu J, Yang H, Shi Q, Xu Y
Biomaterials 2025 Oct;321:123326
Biomaterials 2025 Oct;321:123326
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ran R, Gong CY, Wu ZL, Zhang SB, Zhang K, Zhou WM, Song W, Dong H, Shi YQ, Zhou KS, Zhang HH
The American journal of pathology 2025 Oct;195(10):1905-1920
The American journal of pathology 2025 Oct;195(10):1905-1920
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Feng J, Miao H, Xiao Z, Xu L, Wang Y, Cao X, Wang J, Wu Z, Xia P, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Rabbits as preclinical animal models of cam morphology: proof of concept.
Li Z, Wan P, Liu X, Jiang G, Li J, Chen D, Zhang W, Tian K
BMC musculoskeletal disorders 2025 Oct 6;26(1):918
BMC musculoskeletal disorders 2025 Oct 6;26(1):918
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model.
Suo J, Wang D, Wang J, Yin X, Hu X, Shao R, Chen S, Sun S, Feng J, Wang L, Feng H, Li Z, Hou W, Zhang L, Chen Y, Zheng X, Wang Z, Zou W
Nature communications 2025 Oct 22;16(1):9325
Nature communications 2025 Oct 22;16(1):9325
Glycolytic Metabolite 3-Phosphoglycerate Induced by Inflammation Inhibits Chondrocyte Survival.
Zhao Y, Gao WJ, Xue Y, Zhang JN, Li ZY, Chen QM, Wu MJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71071
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71071
CORM-3 mitigates osteoarthritis by anti-inflammation and enhancing autophagy via inhibiting MAPK and mTOR pathways.
Li J, Zeng Y, Wang S, Chen X, Huang H, Gan X, Kang H
International immunopharmacology 2025 Oct 10;163:115296
International immunopharmacology 2025 Oct 10;163:115296
An aptamer specifically targeting mCRP ameliorates experimental arthritis.
Wang Z, Xie D, Zhu P, Guo J, Cao C, Du Y, Lu A, Liang C
Journal of orthopaedic translation 2025 Nov;55:228-244
Journal of orthopaedic translation 2025 Nov;55:228-244
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Tu YJ, Liu YQ, Pan YY, Cai HY, Liu C
World journal of stem cells 2025 Nov 26;17(11):112393
World journal of stem cells 2025 Nov 26;17(11):112393
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Wang Y, Tan L, Yang Y, Duan H, Liu C, Zhao J, Zhou Y, Li C, Liu M
Nature communications 2025 Nov 20;16(1):11253
Nature communications 2025 Nov 20;16(1):11253
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis.
Zhang JY, Xiang XN, Wang Q, Wang XX, Guan AJ, He CQ, Yu X, He HC
The American journal of sports medicine 2025 May;53(6):1428-1439
The American journal of sports medicine 2025 May;53(6):1428-1439
Vitamins D and K jointly protect against osteoarthritis via regulating OSCAR during osteoclastogenesis.
Zhao Y, Ou Q, Huang H, Li D, Chen J, Xue S, Zhou Z, Ruan G, Ding C
Journal of orthopaedic translation 2025 May;52:387-403
Journal of orthopaedic translation 2025 May;52:387-403
Establishment and characterization of an inflammatory cartilaginous organoids model for organoid transplantation study.
Zhang Y, Fang Q, Peng Y, Liu H, Tang J, Ma R, Wang W
Journal of orthopaedic translation 2025 May;52:376-386
Journal of orthopaedic translation 2025 May;52:376-386
Injectable visible light cross-linking aldehyde-based methacrylated hyaluronic acid hydrogels enhance cartilage repair via improved BMSC homing and chondrogenic differentiation.
Wang D, Zhong Q, Xu Y, Fu J, Xie J, Chen R, Lei M, Tang Z, Mai H, Li H, Shi Z, Zheng S, Cheng H
International journal of biological macromolecules 2025 May;307(Pt 2):141857
International journal of biological macromolecules 2025 May;307(Pt 2):141857
WTAP improves chondrocyte loss and dysfunctions to ameliorate osteoarthritis through mediating the mA methylation and mRNA stability of IL-33.
Yang W, Hu L, Tian Y, Yang Y, Guo W, Xiao K, Yang R, Yang H, Zhou Z, Cheng C
International journal of biological macromolecules 2025 May;306(Pt 3):141330
International journal of biological macromolecules 2025 May;306(Pt 3):141330
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration.
Liu S, Hu Y, Xu W, Liu W, Wang B, Zeng X, Shao Z, Yang C, Xiong L, Cai X
Autophagy 2025 May;21(5):979-995
Autophagy 2025 May;21(5):979-995
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
Li W, Shi Z, Jing H, Dou Y, Liu X, Zhang M, Qiu Z, Heger Z, Li N
Nature communications 2025 May 10;16(1):4344
Nature communications 2025 May 10;16(1):4344
A light-cured injectable composite hydrogel based on chitosan and decellularized matrix modulates stem cell aggregation behavior for accelerating cartilage defect repair.
Feng P, He C, Li G, Li J, Luo Y, Chen Y, Tang Y, Ma J, Ke C
International journal of biological macromolecules 2025 Mar;295:139711
International journal of biological macromolecules 2025 Mar;295:139711
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Feng X, Ma Y, Zhao Y, Zhao Z, Song Z, Lin L, Wang W
Molecular immunology 2025 Mar;179:94-105
Molecular immunology 2025 Mar;179:94-105
circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.
Liu C, Yu C, Duan Y, Li J, Chen X, Xu W, Qiu S
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Acta biochimica et biophysica Sinica 2025 Mar 5;57(10):1636-1646
Microalgae-Derived Extracellular Vesicles Synergize with Herbal Hydrogel for Energy Homeostasis in Osteoarthritis Treatment.
Liang F, Zheng Y, Zhao C, Li L, Hu Y, Wang C, Wang R, Feng T, Liu X, Cui J, Zhong D, Zhou M
ACS nano 2025 Mar 4;19(8):8040-8057
ACS nano 2025 Mar 4;19(8):8040-8057
Recapitulation of endochondral ossification by hPSC-derived SOX9(+) sclerotomal progenitors.
Xiong J, Ma R, Xie K, Shan C, Chen H, Wang Y, Liao Y, Deng Y, Ye G, Wang Y, Zhu Q, Zhang Y, Cai H, Guo W, Yin Y, Li Z
Nature communications 2025 Mar 21;16(1):2781
Nature communications 2025 Mar 21;16(1):2781
Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation.
Meng P, Liu L, Jiang N, Hao S, Yao C, Liu H, Zhang Y, Zhang F, Jia Y, Guo X
European journal of nutrition 2025 Mar 19;64(3):129
European journal of nutrition 2025 Mar 19;64(3):129
Orientin alleviates chondrocyte senescence and osteoarthritis by inhibiting PI3K/AKT pathway.
Chen H, Liu S, Xing J, Wen Y, Chen L
Bone & joint research 2025 Mar 14;14(3):245-258
Bone & joint research 2025 Mar 14;14(3):245-258
Metformin-Loaded Tannic Acid Nanoparticles Attenuate Osteoarthritis by Promoting Chondrocyte Mitochondria Homeostasis Based on Mitocytosis.
Da W, Deng X, Chen Q, Yang Y, Jiang S, Chen X, Lu G, Shen B
Biomacromolecules 2025 Mar 10;26(3):1507-1519
Biomacromolecules 2025 Mar 10;26(3):1507-1519
Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.
Yang S, Shi J, Qiao Y, Teng Y, Zhong X, Wu T, Liu C, Ge J, Yang H, Zou J
ACS biomaterials science & engineering 2025 Mar 10;11(3):1486-1497
ACS biomaterials science & engineering 2025 Mar 10;11(3):1486-1497
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
Wang W, Jiang C, Chen JH, Chen YL, Zhang ZW, Yang ZC, Li J, Li XC
JOR spine 2025 Jun;8(2):e70061
JOR spine 2025 Jun;8(2):e70061
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Fan Y, Niu Z, Yin L, Yao L, Ding S, Tong Y, Wang J, Hong Z, Chen J, Zhang Q, Ji L, Chen J, Xia C, Bi Q
Materials today. Bio 2025 Jun;32:101778
Materials today. Bio 2025 Jun;32:101778
The phenotypic characterization of mouse floxed Fam20b chondrocytes, a novel articular cartilage-derived cell line with differentiation potential.
Wu X, Zhu L, Xia L, Gui L, Cong W
Regenerative therapy 2025 Jun;29:108-116
Regenerative therapy 2025 Jun;29:108-116
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP.
Su J, Sun X, Chen X, Wei K, Luo D, Yang S, Zhang C, Xu J, Deng Z
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Cellular & molecular biology letters 2025 Jun 9;30(1):67
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics.
Wu Y, Li A, Sun N, Jiang Z, Li Y, Zhou Z, Li X, Zhao D, Leng X, Dong H
International immunopharmacology 2025 Jun 5;157:114785
International immunopharmacology 2025 Jun 5;157:114785
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
Chen H, Zhao D, Liu S, Zhong Y, Wen Y, Chen L
International immunopharmacology 2025 Jun 26;159:114911
International immunopharmacology 2025 Jun 26;159:114911
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
FSTL1 Can Be a Promising Target in TMJ Osteoarthritis via Regulating Chondrocyte Mitophagy and Apoptosis.
Li F, Qian W, Wang J, Gao M
The Journal of craniofacial surgery 2025 Jun 1;36(4):1401-1407
The Journal of craniofacial surgery 2025 Jun 1;36(4):1401-1407
RETRACTED ARTICLE: Administration of methylprednisolone do not affect the spinal scar component of spinal cord injury.
Liu X, Xu Y, Wang Y, Peng X, Jian J, Wang X, Wang T
The journal of spinal cord medicine 2025 Jul;48(4):745-754
The journal of spinal cord medicine 2025 Jul;48(4):745-754
Blocking the LRH-1/LCN2 axis by ML-180, an LRH-1 inverse agonist, ameliorates osteoarthritis via inhibiting the MAPK pathway.
Li J, Zhang Y, Gan X, Li J, Xia G, He L, Xia C, Zhang W, Akhtar Ali K, Zhu M, Huang H
Biochemical pharmacology 2025 Jul;237:116922
Biochemical pharmacology 2025 Jul;237:116922
PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.
Yue Z, Gong W, Chu H, Li Y
Tissue engineering and regenerative medicine 2025 Jul;22(5):705-718
Tissue engineering and regenerative medicine 2025 Jul;22(5):705-718
Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.
Zhou Z, Zhang B, Liu L, Yang J, Wang Y, Lv C, Zhang H, Wei Y, Jiang Z, Peng Z, Zhao D, Leng X, Li X, Su H, Dong H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503909
Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation.
Li J, Ren L, Wan L, Liu M, Zhao M, Lin Y, Zheng J, Tang Y, Luo Y, Ma Y, Wang L, Cao P, Chen Z, Ren W, Wang F
Journal of nanobiotechnology 2025 Jul 8;23(1):492
Journal of nanobiotechnology 2025 Jul 8;23(1):492
Periplocin targets LRP4 to regulate metabolic homeostasis and anti-inflammation for the treatment of IVDD.
Liu Z, Qiao F, Liu D, Kong X, Liu K, Gu H, Zhang Y, Meng Q, Cheng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156885
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
Deng C, Yu L, Zhao X, Chen Y, Mei J, Wei J, Chen X, Lei G, Zeng C
Science advances 2025 Jul 25;11(30):eadv4238
Science advances 2025 Jul 25;11(30):eadv4238
Obesity hinders the efficacy of adipose-derived stem cells for knee osteoarthritis by reducing the proportion of DPP4+ stem cells.
Tang Y, Xu ZY, Song SS, Song YJ, Yang LJ, Wang L, Liu Y, Qian SW, Pang ZY, Tang QQ, Yin F
Stem cells translational medicine 2025 Jul 24;14(8)
Stem cells translational medicine 2025 Jul 24;14(8)
Three-Dimensional-Printed Ordered Bredigite Scaffolds with Dual Bioactivities Promote Osteochondral Regeneration.
Zhao L, Yang S, Zhang X, Feng G, Lu J, Zhang Z
ACS applied materials & interfaces 2025 Jul 23;17(29):41707-41718
ACS applied materials & interfaces 2025 Jul 23;17(29):41707-41718
Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration.
Luo P, Cheng Y, Luo Y, Zhang N, Cao J, Wang H, Jiang X, Wang Q, Wu X, Liu Y, Mao J, Zhou X, Nie JJ, Chen D
ACS applied materials & interfaces 2025 Jul 2;17(26):37601-37616
ACS applied materials & interfaces 2025 Jul 2;17(26):37601-37616
Unveiling the therapeutic potential of phenolic compounds from Boletus edulis in osteoarthritis treatment.
Paesa M, Izquierdo MD, Remírez de Ganuza C, Ferreira-Santos P, Rodríguez-Yoldi MJ, Mendoza G
Scientific reports 2025 Jul 10;15(1):24865
Scientific reports 2025 Jul 10;15(1):24865
Bioengineered chondrocyte-products from human induced pluripotent stem cells are useful for repairing articular cartilage injury in minipig model.
Takihira S, Takao T, Fujisawa Y, Yamada D, Hanaki S, Inoue T, Otake S, Yoshida A, Yamada K, Miyazawa S, Nakata E, Ozaki T, Takarada T
NPJ Regenerative medicine 2025 Jul 1;10(1):31
NPJ Regenerative medicine 2025 Jul 1;10(1):31
Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy.
Wu C, Huang Z, Chen J, Li N, Cai Y, Chen J, Ruan G, Han W, Ding C, Lu Y
Biomaterials 2025 Jan;312:122720
Biomaterials 2025 Jan;312:122720
Electrohydrodynamic-Printed Dual-Triphase Microfibrous Scaffolds Reshaping the Lipidomic Profile for Enthesis Healing in a Rat Rotator Cuff Repair Model.
Bai L, Kasimu A, Wang S, Qiu Z, Xu M, Qu X, Chen B, Liu Q, Ai Y, Li M, Xiu J, Liu K, Wen N, He J, Zhang J, Yin Z
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(2):e2406069
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(2):e2406069
Garlic-derived Exosomes Alleviate Osteoarthritis Through Inhibiting the MAPK Signaling Pathway.
Liu Y, Nie M, Li X, Wang H, Ren S, Zou D, Liu J, Li R
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
Applied biochemistry and biotechnology 2025 Jan;197(1):518-533
The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.
Duan A, Ma Z, Shao X, Xiong Z, Zhang C, Liu W, Wang G, Hu S, Lin W
Clinical and translational medicine 2025 Jan;15(1):e70118
Clinical and translational medicine 2025 Jan;15(1):e70118
Tree shrew as a new animal model for musculoskeletal disorders and aging.
Wei X, Li H, Qiu J, Jiao J, Guo X, Yin G, Yang P, Han Y, Zhao Q, Zeng H, Rao Z, Gao X, Li K, Lai P, Zhang S, Yang C, Lu D, Bai X
Bone research 2025 Jan 2;13(1):5
Bone research 2025 Jan 2;13(1):5
Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.
Chen Y, Li G, Ge Y, Liu S, Weng J, Lin J, Xiong A, Zeng H, Wu X, Yang J, Yu F
ACS biomaterials science & engineering 2025 Jan 13;11(1):493-505
ACS biomaterials science & engineering 2025 Jan 13;11(1):493-505
Cpeb1 remodels cell type-specific translational program to promote fear extinction.
Zhang J, Yang CQ, Liu ZQ, Wu SP, Li ZG, Zhang LM, Fan HW, Guo ZY, Man HY, Li X, Lu YM, Zhu LQ, Liu D
Science advances 2025 Jan 10;11(2):eadr8687
Science advances 2025 Jan 10;11(2):eadr8687
Cellular senescence contributes to spontaneous repair of the rat meniscus.
Aimono Y, Endo K, Sekiya I
Aging cell 2025 Feb;24(2):e14385
Aging cell 2025 Feb;24(2):e14385
Effect of 3D-Printed Polycaprolactone Scaffold With Powdery/Smooth Micromorphology on Local Immune Environments.
Hou L, Meng Z, Zhang J, Jiao Y, Chang K, He J, Zhang J
Journal of biomedical materials research. Part A 2025 Feb;113(2):e37869
Journal of biomedical materials research. Part A 2025 Feb;113(2):e37869
Mechanosensitive lncRNA H19 promotes chondrocyte autophagy, but not pyroptosis, by targeting miR-148a in post-traumatic osteoarthritis.
Zhou X, Cao H, Liao T, Hua W, Zhao R, Wang D, Deng H, Yang Y, Liu S, Ni G
Non-coding RNA research 2025 Feb;10:163-176
Non-coding RNA research 2025 Feb;10:163-176
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies.
Auer S, Schicht M, Hoffmann L, Budday S, Frischknecht R, Blümcke I, Paulsen F
Cells 2025 Feb 20;14(5)
Cells 2025 Feb 20;14(5)
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T, Song F, Wang Q, Niu Y, Jiang F, Wang J, Sheng L, Dai J
Bone research 2025 Feb 14;13(1):23
Bone research 2025 Feb 14;13(1):23
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.
Li X, Li X, Zhou D, Xu Y, Sun B, Hu Y, Zhu Y, Hu J, Pang Z, Zhao C, Gao Y, Long Y, Li P, Zhou Q, Wang Y
Materials today. Bio 2025 Dec;35:102347
Materials today. Bio 2025 Dec;35:102347
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Tan H, Fang C, Tan Y, Wang Z, Zhou Y, Li X
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
DDRGK1 preserves intervertebral disc development through ufmylation.
Lu M, Zhou T, Yang X, Liu K, Rong K, Ma P, Qin A, Zhao J
Cellular and molecular life sciences : CMLS 2025 Dec 29;83(1):47
Cellular and molecular life sciences : CMLS 2025 Dec 29;83(1):47
In Situ Supply and Anchoring of Glycosaminoglycan by Dual-Modified Hydrogel Loaded with Glycoengineered Stem Cells for Attenuating Disc Degeneration.
Li Y, Cao J, Liang C, Zhang Y, Shi K, Xu H, Xia K, Huang X, Yu C, Chen J, Cheng F, Chen J, Wang R, Wang K, Li F, Chen Q, Gao J, Zhou X
ACS nano 2025 Dec 2;19(47):40620-40640
ACS nano 2025 Dec 2;19(47):40620-40640
Dual-functional ROS-responsive hydrogel alleviates temporomandibular joint osteoarthritis by enhancing cartilage repair and mitigating inflammation.
Kuang Y, Hua B, Ye X, Zhao Y, Yu M, Liu X
Materials today. Bio 2025 Aug;33:102103
Materials today. Bio 2025 Aug;33:102103
Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage.
Zhang Y, Fu M, Zhou C, Wang X, Jiang Z, Jiang C, Guo S, Pang Z, Wang C, Yu T, An S, Wang X, Wang Z
EMBO molecular medicine 2025 Aug;17(8):2137-2162
EMBO molecular medicine 2025 Aug;17(8):2137-2162
Pure platelet-rich plasma delays intervertebral disc degeneration by activating SIRT1-mediated autophagy in nucleus pulposus cells.
Han J, Ding Z, Huang J, Zhang Y, Ding Y
Journal of orthopaedic surgery and research 2025 Aug 22;20(1):786
Journal of orthopaedic surgery and research 2025 Aug 22;20(1):786
Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis.
Gao C, Feng Y, Liu S, Chen B, Ding M, Du D, Zhang W, Wilson DA, Tu Y, Peng F
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(17):e2416349
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(17):e2416349
Deciphering cartilage neuro-immune interactions and innervation profile through 3D engineered osteoarthritic micropathophysiological system.
Kahraman E, Vasconcelos D, Ribeiro B, Monteiro AC, Mastromatteo E, Bortolin A, Couto M, Boschis L, Lamghari M, Neto E
Materials today. Bio 2025 Apr;31:101491
Materials today. Bio 2025 Apr;31:101491
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Hu X, Xie J, Su J
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Fullerol Initiates Stem Cell-Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling.
Liu H, Zhu Y, Chen W, Sheng R, Liu C, Sun Y, Liu J, Wang M, Lu J, Chen J, Zhang W
ACS applied materials & interfaces 2025 Apr 30;17(17):25011-25034
ACS applied materials & interfaces 2025 Apr 30;17(17):25011-25034
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation.
Li L, Zhou R, Yue Z, Li H, Han Y, Zhang L, Zhu J
Functional & integrative genomics 2025 Apr 28;25(1):95
Functional & integrative genomics 2025 Apr 28;25(1):95
FAM20B-Catalyzed Glycosylation Regulates the Chondrogenic and Osteogenic Differentiation of the Embryonic Condyle by Controlling IHH Diffusion and Release.
Chen X, Liu H, Huang Y, Li L, Jiang X, Liu B, Li N, Zhu L, Liu C, Xiao J
International journal of molecular sciences 2025 Apr 24;26(9)
International journal of molecular sciences 2025 Apr 24;26(9)
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes.
Wang W, Cheng Z, Yu M, Liu K, Duan H, Zhang Y, Huang X, Li M, Li C, Hu Y, Luo Z, Liu M
Nature communications 2025 Apr 1;16(1):3131
Nature communications 2025 Apr 1;16(1):3131
Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression.
Lv Z, Wang P, Li W, Xie Y, Sun W, Jin X, Jiang R, Fei Y, Liu Y, Shi T, Guo H, Sun Z, Lin J, Wang X, Tan G, Wu Y, Bao N, Shi D
Research (Washington, D.C.) 2024;7:0316
Research (Washington, D.C.) 2024;7:0316
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Wu Q, Yao X, Shan N, Cai Y, Fan Y
Folia histochemica et cytobiologica 2024;62(3):154-164
Folia histochemica et cytobiologica 2024;62(3):154-164
Custom-Made Ce-Mn Bimetallic Nanozyme for the Treatment of Intervertebral Disc Degeneration by Inhibiting Oxidative Stress and Modulating Macrophage M1/M2 Polarization.
Wu J, Chen Z, Huang H, Wang H, Wang X, Lu Z, Xu H, Ma X, Zeng F, Wang H
Biomaterials research 2024;28:0118
Biomaterials research 2024;28:0118
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis.
Liu L, He G, Li Y, Xian Y, He G, Hong Y, Zhang C, Wu D
Biomaterials research 2024;28:0073
Biomaterials research 2024;28:0073
Injectable Inflammation-Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Zhao L, Li Y, Zheng Z, Liu H, Wu D
Advanced healthcare materials 2024 Sep;13(22):e2400717
Advanced healthcare materials 2024 Sep;13(22):e2400717
Suppression of YAP Ameliorates Cartilage Degeneration in Ankle Osteoarthritis via Modulation of the Wnt/β-Catenin Signaling Pathway.
Fan Z, Zhao X, Ma J, Zhan H, Ma X
Calcified tissue international 2024 Sep;115(3):283-297
Calcified tissue international 2024 Sep;115(3):283-297
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Yu H, Lou J, Ni L, Yan M, Zhu K, Mao S, Zhu J
Chemical biology & drug design 2024 Sep;104(3):e14620
Chemical biology & drug design 2024 Sep;104(3):e14620
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome.
Wang Y, Zhang W, Yang Y, Qin J, Wang R, Wang S, Fu W, Niu Q, Wang Y, Li C, Li H, Zhou Y, Liu M
Bone research 2024 Sep 6;12(1):53
Bone research 2024 Sep 6;12(1):53
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Promoting chondrogenesis by targeted delivery to the degenerating cartilage in early treatment of osteoarthritis.
Fei Y, Li X, Lv Z, Liu Z, Xie Y, Chen J, Li W, Liu X, Guo H, Liu H, Zhang Z, Wang X, Fan J, Hu C, Jin X, Jiang R, Xu N, Xia J, Li Y, Shi D
Bioactive materials 2024 Oct;40:624-633
Bioactive materials 2024 Oct;40:624-633
Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.
Zhang TL, Chen WK, Huang XP, Zheng BW, Wu PF, Zheng BY, Jiang LX, Escobar D, Li J, Lv GH, Huang W, Zhou H, Xu Z, Zou MX
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18
ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats.
Gao T, Xu G, Ma T, Lu X, Chen K, Luo H, Chen G, Song J, Ma X, Fu W, Zheng C, Xia X, Jiang J
Advanced healthcare materials 2024 Oct;13(27):e2401103
Advanced healthcare materials 2024 Oct;13(27):e2401103
An anti-senescence hydrogel with pH-responsive drug release for mitigating intervertebral disc degeneration and low back pain.
Wang W, Liu L, Ma W, Zhao L, Huang L, Zhou D, Fan J, Wang J, Liu H, Wu D, Zheng Z
Bioactive materials 2024 Nov;41:355-370
Bioactive materials 2024 Nov;41:355-370
Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy.
Ju Y, Ma S, Fu M, Wu M, Li Y, Wang Y, Tao M, Lu Z, Guo J
Acta biomaterialia 2024 Nov;189:116-129
Acta biomaterialia 2024 Nov;189:116-129
Systematic analysis of lysine lactylation in nucleus pulposus cells.
Sheng L, Xu H, Wang Y, Ni J, Xiang T, Xu H, Zhou X, Wei K, Dai J
iScience 2024 Nov 15;27(11):111157
iScience 2024 Nov 15;27(11):111157
Efficient Production of Chondrocyte Particles from Human iPSC-Derived Chondroprogenitors Using a Plate-Based Cell Self-Aggregation Technique.
Hanaki S, Yamada D, Takao T, Iwai R, Takarada T
International journal of molecular sciences 2024 Nov 10;25(22)
International journal of molecular sciences 2024 Nov 10;25(22)
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Development of alginate-collagen interpenetrating network for osteoarthritic cartilage by in situ softening.
Du G, Zhang J, Shuai Q, Li L, Zhang Q, Shi R
International journal of biological macromolecules 2024 May;266(Pt 2):131259
International journal of biological macromolecules 2024 May;266(Pt 2):131259
An integrated multi-omics analysis reveals osteokines involved in global regulation.
Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X
Cell metabolism 2024 May 7;36(5):1144-1163.e7
Cell metabolism 2024 May 7;36(5):1144-1163.e7
siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration.
Ma M, Zhang C, Zhong Z, Wang Y, He X, Zhu D, Qian Z, Yu B, Kang X
Bone & joint research 2024 May 21;13(5):247-260
Bone & joint research 2024 May 21;13(5):247-260
Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.
Liu L, Sun H, Zhang Y, Liu C, Zhuang Y, Liu M, Ai X, Long D, Huang B, Li C, Zhou Y, Dong S, Feng C
JOR spine 2024 Mar;7(1):e1316
JOR spine 2024 Mar;7(1):e1316
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy.
Lin J, Wang L, Wu Y, Xiang Q, Zhao Y, Zheng X, Jiang S, Sun Z, Fan D, Li W
Experimental & molecular medicine 2024 Mar;56(3):747-759
Experimental & molecular medicine 2024 Mar;56(3):747-759
Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
Li L, Fan Q, Zhao Y, Zhang Q, Qin G, Li C, Li W
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Journal of orthopaedic surgery and research 2024 Mar 25;19(1):198
Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.
Chen X, Song Y, Chen G, Zhang B, Bai Y, Sun C, Fan D, Chen Z
Biomedicines 2024 Mar 18;12(3)
Biomedicines 2024 Mar 18;12(3)
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis.
Chang K, Lin L, Cui T, Zhao H, Li J, Liu C, Gao D, Lu S
Molecular neurobiology 2024 Jun;61(6):3607-3618
Molecular neurobiology 2024 Jun;61(6):3607-3618
LIPUS regulates the progression of knee osteoarthritis in mice through primary cilia-mediated TRPV4 channels.
Wu S, Zhou H, Ling H, Sun Y, Luo Z, Ngo T, Fu Y, Wang W, Kong Y
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):785-798
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):785-798
Platelet-rich plasma alleviates knee arthritis in rats by inhibiting p65.
Zhuo F, Jia X, Wang Z, Zhang Y, Yan X
Cell and tissue banking 2024 Jun;25(2):463-473
Cell and tissue banking 2024 Jun;25(2):463-473
Injectable Ozone-Rich Nanocomposite Hydrogel Loaded with D-Mannose for Anti-Inflammatory and Cartilage Protection in Osteoarthritis Treatment.
Wu H, Wang J, Lin Y, He W, Hou J, Deng M, Chen Y, Liu Q, Lu A, Cui Z, Guan D, Yu B
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309597
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309597
Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection.
Yu M, Park C, Son YB, Jo SE, Jeon SH, Kim YJ, Han SB, Hong JT, Son DJ
Nutrients 2024 Jun 14;16(12)
Nutrients 2024 Jun 14;16(12)
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.
Zhou H, He J, Liu R, Cheng J, Yuan Y, Mao W, Zhou J, He H, Liu Q, Tan W, Shuai C, Deng Y
Bioactive materials 2024 Jul;37:51-71
Bioactive materials 2024 Jul;37:51-71
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320
Oral diseases 2024 Jul;30(5):3308-3320
Activation of Notch Signaling Pathway is involved in Extracellular Matrix Degradation in human induced pluripotent stem cells chondrocytes induced by HT-2 toxin.
Meng P, Liu H, Liu L, Wen Y, Zhang F, Zhang Y, Jia Y, Zhang Y, Zhang F, Guo X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jul;189:114724
Biofabrication of Tissue-Engineered Cartilage Constructs Through Faraday Wave Bioassembly of Cell-Laden Gelatin Microcarriers.
Zhu J, Luo Q, Yang G, Xiao L
Advanced healthcare materials 2024 Jul;13(19):e2304541
Advanced healthcare materials 2024 Jul;13(19):e2304541
A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration.
Hu C, Huang R, Xia J, Hu X, Xie D, Jin Y, Qi W, Zhao C, Hu Z
Journal of nanobiotechnology 2024 Jul 28;22(1):445
Journal of nanobiotechnology 2024 Jul 28;22(1):445
The Combined Intraosseous Administration of Orthobiologics Outperformed Isolated Intra-articular Injections in Alleviating Pain and Cartilage Degeneration in a Rat Model of MIA-Induced Knee Osteoarthritis.
Zhang K, Yu J, Li J, Fu W
The American journal of sports medicine 2024 Jan;52(1):140-154
The American journal of sports medicine 2024 Jan;52(1):140-154
JD-312 - A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression.
Gao J, Pei H, Lv F, Niu X, You Y, He L, Hu S, Shah KM, Liu M, Chen Y, Du B, Xiong H, Luo J
Journal of orthopaedic translation 2024 Jan;44:60-71
Journal of orthopaedic translation 2024 Jan;44:60-71
microRNA-365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting EFNA3.
Jiang C, Liu Y, Zhao W, Yang Y, Ren Z, Wang X, Hao D, Du H, Yin S
Journal of cellular and molecular medicine 2024 Jan;28(2):e18054
Journal of cellular and molecular medicine 2024 Jan;28(2):e18054
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology.
Tang S, Yao L, Ruan J, Kang J, Cao Y, Nie X, Lan W, Zhu Z, Han W, Liu Y, Tian J, Seale P, Qin L, Ding C
Science translational medicine 2024 Jan 24;16(731):eadf4590
Science translational medicine 2024 Jan 24;16(731):eadf4590
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4.
Zhuang Y, Liu L, Liu M, Fu J, Ai X, Long D, Leng X, Zhang Y, Gong X, Shang X, Li C, Huang B, Zhou Y, Ning X, Dong S, Feng C
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166961
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166961
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Wang X, Li X, Zhou J, Lei Z, Yang X
Chemico-biological interactions 2024 Feb 25;390:110890
Chemico-biological interactions 2024 Feb 25;390:110890
Lei's formula attenuates osteoarthritis mediated by suppression of chondrocyte senescence via the mTOR axis: in vitro and in vivo experiments.
Zhou X, Li WK, Zhuang C, Zhou XC, Zhao XF, Pan Y, Guo WX, Yang YW, Sheng CZ, Xie ZF, Yu JS, Chen YX, Wang LK, Ma TY, Zhu KX, Xiang KM, Zhuang RJ
Aging 2024 Feb 23;16(5):4250-4269
Aging 2024 Feb 23;16(5):4250-4269
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.
Wu D, Yang S, Gong Z, Zhu X, Hong J, Wang H, Xu W, Lai J, Wang X, Lu J, Fang X, Jiang G, Zhu J
Materials today. Bio 2024 Dec;29:101353
Materials today. Bio 2024 Dec;29:101353
Tissue-engineered collagen matrix loaded with rat adipose-derived stem cells/human amniotic mesenchymal stem cells for rotator cuff tendon-bone repair.
Shi J, Yao H, Chong H, Hu X, Yang J, Dai X, Liu D, Wu Z, Dang M, Fei W, Wang DA
International journal of biological macromolecules 2024 Dec;282(Pt 4):137144
International journal of biological macromolecules 2024 Dec;282(Pt 4):137144
The active ingredient of Evodia rutaecarpa reduces inflammation in knee osteoarthritis rats through blocking calcium influx and NF-κB pathway.
Gao Y, Wang S, Gao Y, Yang L
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Basic & clinical pharmacology & toxicology 2024 Dec;135(6):705-719
Ultra-Long-Term Anti-Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage.
Wei S, Shou Z, Yang D, Sun L, Guo Y, Wang Y, Zan X, Li L, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407425
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407425
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
Wei X, Qiu J, Lai R, Wei T, Lin Z, Huang S, Jiang Y, Kuang Z, Zeng H, Gong Y, Xie X, Yang J, Zhang Y, Zhang S, Zou Z, Gao X, Bai X
Cell stem cell 2024 Dec 5;31(12):1813-1830.e8
Cell stem cell 2024 Dec 5;31(12):1813-1830.e8
High-Intensity Interval Training Increases Osteoarthritis-Associated Pain-Sensitive Threshold Through Reduction of Perineuronal Nets of the Medial Prefrontal Cortex in Rats.
Zhang X, Kong FE, Lin CS, Ye ZQ, Chen AL, Cheng K, Li XP
Physiological research 2024 Dec 31;73(6):1085-1097
Physiological research 2024 Dec 31;73(6):1085-1097
YAP1 exacerbates pyroptosis and senescence in nucleus pulposus cells by promoting BNIP3-mediated mitophagy.
Peng X, Ji HY, Gao JW, Hong SH, Zhang T, Yang G, Wu X, Gao Y, Wang K
International immunopharmacology 2024 Dec 25;143(Pt 2):113434
International immunopharmacology 2024 Dec 25;143(Pt 2):113434
T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification.
Zhang B, Li H, Qi F, Yu Q, Jiang H, Lin B, Dong H, Li H, Yu J
International immunopharmacology 2024 Dec 25;143(Pt 2):113390
International immunopharmacology 2024 Dec 25;143(Pt 2):113390
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Age-dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy.
Lehner A, Hoffmann L, Rampp S, Coras R, Paulsen F, Frischknecht R, Hamer H, Walther K, Brandner S, Hofer W, Pieper T, Reisch LM, Bien CG, Blumcke I
Epilepsia open 2024 Aug;9(4):1372-1381
Epilepsia open 2024 Aug;9(4):1372-1381
Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration.
Inoue Y, Kumagai K, Ishikawa K, Kato I, Kusaba Y, Naka T, Nagashima K, Choe H, Ike H, Kobayashi N, Inaba Y
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Aug;42(8):1880-1889
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Aug;42(8):1880-1889
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect.
Lu X, Dai S, Huang B, Li S, Wang P, Zhao Z, Li X, Li N, Wen J, Sun Y, Man Z, Liu B, Li W
Bioactive materials 2024 Aug;38:137-153
Bioactive materials 2024 Aug;38:137-153
PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Zhao Q, Chen X, Qu N, Qiu J, Zhang B, Xia C
Journal of cellular and molecular medicine 2024 Aug;28(16):e70027
Journal of cellular and molecular medicine 2024 Aug;28(16):e70027
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes.
Xie S, Wang L, Lu C, Chen H, Ding Y, Jian X, Zhang Z, Zhu L
Cellular signalling 2024 Aug;120:111220
Cellular signalling 2024 Aug;120:111220
Raphanus sativus Linne Protects Human Nucleus Pulposus Cells against H(2)O(2)-Induced Damage by Inhibiting TREM2.
Kim H, Yeo C, Hong JY, Jeon WJ, Kim H, Lee J, Lee YJ, Baek SH, Ha IH
Biology 2024 Aug 9;13(8)
Biology 2024 Aug 9;13(8)
Mulberroside A mitigates intervertebral disc degeneration by inhibiting MAPK and modulating Ppar-γ/NF-κB pathways.
Xu T, Zhao H, Fang X, Wang S, Li J, Wu H, Hu W, Lu R
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
Journal of inflammation (London, England) 2024 Aug 28;21(1):32
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration.
Liu L, Wang W, Huang L, Xian Y, Ma W, Fan J, Li Y, Liu H, Zheng Z, Wu D
Biomaterials 2024 Apr;306:122509
Biomaterials 2024 Apr;306:122509
Baicalin Maintains Articular Cartilage Homeostasis and Alleviates Osteoarthritis by Activating FOXO1.
Wei Q, Yu Z, Yang P, Chen X
Journal of medicinal food 2024 Apr;27(4):301-311
Journal of medicinal food 2024 Apr;27(4):301-311
Injectable silk fibroin peptide nanofiber hydrogel composite scaffolds for cartilage regeneration.
Wu D, Li J, Wang C, Su Z, Su H, Chen Y, Yu B
Materials today. Bio 2024 Apr;25:100962
Materials today. Bio 2024 Apr;25:100962
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking.
Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X, Zhang Y, Feng X, Wang K, Yang C
Autophagy 2024 Apr;20(4):809-829
Autophagy 2024 Apr;20(4):809-829
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167083
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Qian Z, Xia M, Zhao T, Li Y, Li G, Zhang Y, Li H, Yang L
Clinical and translational medicine 2024 Apr;14(4):e1661
Clinical and translational medicine 2024 Apr;14(4):e1661
Role of Galectin-3 in intervertebral disc degeneration: an experimental study.
Li J, Han N, Liu Z, Osman A, Xu L, Song J, Xiao Y, Hu W
BMC musculoskeletal disorders 2024 Apr 1;25(1):249
BMC musculoskeletal disorders 2024 Apr 1;25(1):249
Age-Related Gene and Protein Expression in Mouse Mandibular Condyle Analyzed by Cap Analysis of Gene Expression and Immunohistochemistry.
Yang MC, Nakamura M, Kageyama Y, Igari Y, Sasano Y
Gerontology 2023;69(11):1295-1306
Gerontology 2023;69(11):1295-1306
Immunohistochemical characterization of the mandibular condyle for type I and II collagen, aggrecan, MMP-9, and MMP-13 in MMP-2-deficient mice.
Yang MC, Nakamura M, Mayanagi M, Sasano Y
Biomedical research (Tokyo, Japan) 2023;44(2):65-72
Biomedical research (Tokyo, Japan) 2023;44(2):65-72
Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion.
Liu B, Wu Y, Liang T, Zhou Y, Chen G, He J, Ji C, Liu P, Zhang C, Lin J, Shi K, Luo Z, Liu N, Su X
Mediators of inflammation 2023;2023:3706421
Mediators of inflammation 2023;2023:3706421
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression.
Zhou M, Zhai C, Shen K, Liu G, Liu L, He J, Chen J, Xu Y
Journal of immunology research 2023;2023:2061071
Journal of immunology research 2023;2023:2061071
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Chen J, Xu W, Dai T, Jiao S, Xue X, Jiang J, Li S, Meng Q
International journal of nanomedicine 2023;18:5871-5890
International journal of nanomedicine 2023;18:5871-5890
Digoxin protects against intervertebral disc degeneration via TNF/NF-κB and LRP4 signaling.
Meng Q, Liu K, Liu Z, Liu J, Tian Z, Qin S, Wei J, Cheng L
Frontiers in immunology 2023;14:1251517
Frontiers in immunology 2023;14:1251517
Liquid platelet-rich fibrin produced via horizontal centrifugation decreases the inflammatory response and promotes chondrocyte regeneration in vitro.
Li H, Xia T, Zeng H, Qiu Y, Wei Y, Cheng Y, Wang Y, Zhang X, Ke J, Miron R, He Q
Frontiers in bioengineering and biotechnology 2023;11:1301430
Frontiers in bioengineering and biotechnology 2023;11:1301430
Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats.
Chen Q, Yang Q, Pan C, Ding R, Wu T, Cao J, Wu H, Zhao X, Li B, Cheng X
Frontiers in bioengineering and biotechnology 2023;11:1073238
Frontiers in bioengineering and biotechnology 2023;11:1073238
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z, Yang W, Yang H, Zhou Z
The American journal of pathology 2023 Sep;193(9):1234-1247
The American journal of pathology 2023 Sep;193(9):1234-1247
Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.
Li J, Li X, Zhou S, Wang Y, Ying T, Wang Q, Wu Y, Zhao F
Clinical and translational medicine 2023 Sep;13(9):e1415
Clinical and translational medicine 2023 Sep;13(9):e1415
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
Li Y, Li H, Wang L, Xie W, Yuan D, Wen Z, Zhang T, Lai J, Xiong Z, Shan Y, Jiang W
International immunopharmacology 2023 Sep;122:110518
International immunopharmacology 2023 Sep;122:110518
Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas.
Fu J, Zhu Q, Chen Z, Zhao J, Wu S, Zhao M, Xu S, Lai D, Fu G, Zhang W
Biomaterials research 2023 Sep 4;27(1):84
Biomaterials research 2023 Sep 4;27(1):84
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
Lei C, Kan H, Xian X, Chen W, Xiang W, Song X, Wu J, Yang D, Zheng Y
Nature communications 2023 Sep 2;14(1):5360
Nature communications 2023 Sep 2;14(1):5360
Nano-elemental selenium particle developed via supramolecular self-assembly of chondroitin sulfate A and Na(2)SeO(3) to repair cartilage lesions.
Han J, Deng H, Li Y, Qiao L, Jia H, Zhang L, Wang L, Qu C
Carbohydrate polymers 2023 Sep 15;316:121047
Carbohydrate polymers 2023 Sep 15;316:121047
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
Wan J, Li M, Yuan X, Yu X, Chen A, Shao M, Kang H, Cheng P
International journal of molecular medicine 2023 Oct;52(4)
International journal of molecular medicine 2023 Oct;52(4)
Low-intensity pulsed ultrasound irradiation attenuates collagen degradation of articular cartilage in early osteoarthritis-like model mice.
Kojima Y, Watanabe T
Journal of experimental orthopaedics 2023 Oct 23;10(1):106
Journal of experimental orthopaedics 2023 Oct 23;10(1):106
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
Tang Y, Liu Y, Zhu X, Chen Y, Jiang X, Ding S, Zheng Q, Zhang M, Yang J, Ma Y, Xing M, Zhang Z, Ding H, Jin Y, Ma C
iScience 2023 Oct 20;26(10):107838
iScience 2023 Oct 20;26(10):107838
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.
Ni S, Yi N, Yuan H, Li D, Chen X, Zhuang C
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
Phytotherapy research : PTR 2023 Nov;37(11):5394-5406
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
Guo D, Pan H, Lu X, Chen Z, Zhou L, Chen S, Huang J, Liang X, Xiao Z, Zeng H, Shao Y, Qi W, Xie D, Lin C
Arthritis research & therapy 2023 Nov 9;25(1):217
Arthritis research & therapy 2023 Nov 9;25(1):217
Traditional Chinese Medicine formula Bu-Shen-Huo-Xue-Fang (BSHXF) protects nucleus pulposus cells against the inflammatory and oxidative stress-induced degenerative changes.
Li L, Wei X, Li K, Gong H, Zhu L, Yang S, Wang S, Gu J, Chen M, Yin X, Zhan J, Feng M, Yu J, Sun W, Chen X
Journal of pharmaceutical and biomedical analysis 2023 Nov 30;236:115656
Journal of pharmaceutical and biomedical analysis 2023 Nov 30;236:115656
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.
Liu X, Li H, Feng Y, Guo H, Li Y, Ke J, Long X
Arthritis research & therapy 2023 Nov 29;25(1):230
Arthritis research & therapy 2023 Nov 29;25(1):230
Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration.
Yang Y, Zhao X, Wang S, Zhang Y, Yang A, Cheng Y, Chen X
Nature communications 2023 Nov 27;14(1):7771
Nature communications 2023 Nov 27;14(1):7771
Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
Guo J, Ye W, Wu X, Huang H, Li B, Ren Z, Yang Z
Functional & integrative genomics 2023 Nov 1;23(4):329
Functional & integrative genomics 2023 Nov 1;23(4):329
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration.
Shang L, Ma H, Zhang X, Mao R, Ma C, Ruan Z
Clinical and experimental pharmacology & physiology 2023 May;50(5):403-414
Clinical and experimental pharmacology & physiology 2023 May;50(5):403-414
A20 ameliorates disc degeneration by suppressing mTOR/BNIP3 axis-mediated mitophagy.
Peng X, Zhang C, Gao JW, Wang F, Bao JP, Zhou ZM, Sun R, Ji HY, Vlf C, Wu XT
Genes & genomics 2023 May;45(5):657-671
Genes & genomics 2023 May;45(5):657-671
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
Liu L, Zhang Y, Fu J, Ai X, Long D, Leng X, Zhang Y, Huang B, Li C, Zhou Y, Feng C
Journal of orthopaedic translation 2023 May;40:116-131
Journal of orthopaedic translation 2023 May;40:116-131
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Xia G, Wen Z, Zhang L, Huang J, Wang X, Liang C, Cui X, Cao X, Wu S
Experimental gerontology 2023 May;175:112140
Experimental gerontology 2023 May;175:112140
Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.
Yao Z, Qi W, Zhang H, Zhang Z, Liu L, Shao Y, Zeng H, Yin J, Pan H, Guo X, Liu A, Cai D, Bai X, Zhang H
eLife 2023 May 5;12
eLife 2023 May 5;12
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment.
Li G, Liu S, Chen Y, Zhao J, Xu H, Weng J, Yu F, Xiong A, Udduttula A, Wang D, Liu P, Chen Y, Zeng H
Nature communications 2023 May 31;14(1):3159
Nature communications 2023 May 31;14(1):3159
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Li W, Tao C, Mao M, Zhu K
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.
Suo J, Shao R, Yang R, Wang J, Zhang Z, Wang D, Niu N, Zheng X, Zou W
Cell death & disease 2023 May 22;14(5):336
Cell death & disease 2023 May 22;14(5):336
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Chen D, Jiang X, Zou H
Journal of orthopaedic translation 2023 Mar;39:163-176
Journal of orthopaedic translation 2023 Mar;39:163-176
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.
Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159
Regenerative therapy 2023 Mar;22:148-159
Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis.
Liu W, Zhao X, Wu X
Journal of orthopaedic surgery and research 2023 Mar 8;18(1):177
Journal of orthopaedic surgery and research 2023 Mar 8;18(1):177
Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.
Chen G, Tang Q, Yu S, Shen Y, Sun J, Peng J, Yin Y, Feng G, Lu X, Mei G, Zhang Y, Wan Q, Zhang L, Chen L
Cell death and differentiation 2023 Jun;30(6):1503-1516
Cell death and differentiation 2023 Jun;30(6):1503-1516
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488
The journal of gene medicine 2023 Jun;25(6):e3488
Enhanced Cell Penetration and Pluripotency Maintenance of hiPSCs in 3D Natural Chitosan Scaffolds.
Tang Y, Zhou Y, Lin G, Zhang M
Macromolecular bioscience 2023 Jun;23(6):e2200460
Macromolecular bioscience 2023 Jun;23(6):e2200460
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Wan J, Zhu Z, He Z, Wu H, Chen A, Zhu W, Cheng P
International immunopharmacology 2023 Jun;119:110261
International immunopharmacology 2023 Jun;119:110261
TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.
Guo J, Ye W, Wu X, Huang H, Li B, Sun Z, Ren Z, Yang Z
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
Journal of orthopaedic surgery and research 2023 Jun 13;18(1):430
Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice.
Zhang P, Jin Y, Xia W, Wang X, Zhou Z
Journal of orthopaedic translation 2023 Jul;41:1-11
Journal of orthopaedic translation 2023 Jul;41:1-11
The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
Chen S, Zhuang Q, Li P, Zeng J, Peng Y, Ding Z, Cao H, Zheng R, Wang W
Cell and tissue research 2023 Jul;393(1):97-109
Cell and tissue research 2023 Jul;393(1):97-109
EIF4A3-Induced Upregulation of hsa_circ_0040039 is a Biomarker and Aggravates IL-1β-Stimulated Intervertebral Disc Degeneration.
Li L, Cao Y, Deng H, Jia J, Fan X
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
Applied biochemistry and biotechnology 2023 Jul;195(7):4292-4307
GPRC5B protects osteoarthritis by regulation of autophagy signaling.
He L, Xu Z, Niu X, Li R, Wang F, You Y, Gao J, Zhao L, Shah KM, Fan J, Liu M, Luo J
Acta pharmaceutica Sinica. B 2023 Jul;13(7):2976-2989
Acta pharmaceutica Sinica. B 2023 Jul;13(7):2976-2989
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl(-) efflux signaling pathway.
Zhang Z, Xie S, Qian J, Gao F, Jin W, Wang L, Yan L, Chen H, Yao W, Li M, Wang X, Zhu L
Journal of translational medicine 2023 Jul 8;21(1):452
Journal of translational medicine 2023 Jul 8;21(1):452
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression.
Huang H, Yan J, Lan X, Guo Y, Sun M, Zhao Y, Zhang F, Sun J, Lu S
International journal of molecular sciences 2023 Jan 3;24(1)
International journal of molecular sciences 2023 Jan 3;24(1)
Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress.
Yang W, Jia C, Liu L, Fu Y, Wu Y, Liu Z, Yu R, Ma X, Gong A, Liu F, Xia Y, Hou Y, Li Y, Zhang L
Inflammation 2023 Feb;46(1):270-284
Inflammation 2023 Feb;46(1):270-284
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration.
Zhou Z, Suo Y, Bai J, Lin F, Gao X, Shan H, Ni Y, Zhou X, Sheng L, Dai J
Aging and disease 2023 Feb 11;
Aging and disease 2023 Feb 11;
Enhancement and Repair of Degenerative Intervertebral Disc in Rats Using Platelet-Rich Plasma/Ferulic Acid Hydrogel.
Chai Q, Zhang B, Da Y, Wang W, Gao Y, Yao M, Zhu H, Yang X, Zhu Y
Cartilage 2023 Dec;14(4):506-515
Cartilage 2023 Dec;14(4):506-515
Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension.
Takahashi I, Matsuzaki T, Kuroki H, Hoso M
Cartilage 2023 Dec;14(4):482-491
Cartilage 2023 Dec;14(4):482-491
Unravelling diagnostic clusters and immune landscapes of cuproptosis patterns in intervertebral disc degeneration through dry and wet experiments.
Zhang P, He J, Gan Y, Shang Q, Chen H, Zhao W, Cui J, Shen G, Li Y, Jiang X, Zhu G, Ren H
Aging 2023 Dec 29;15(24):15599-15623
Aging 2023 Dec 29;15(24):15599-15623
MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.
Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Journal of nanobiotechnology 2023 Dec 18;21(1):486
Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9.
Xiang Q, Wang J, Cheng Z, Zhao K, Gan W, Chen Y, Zhang Y
Spine 2023 Dec 1;48(23):E401-E408
Spine 2023 Dec 1;48(23):E401-E408
ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C
International immunopharmacology 2023 Aug;121:110433
International immunopharmacology 2023 Aug;121:110433
Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2.
Qin W, Yang L, Chen X, Ye S, Liu A, Chen D, Hu K
International journal of stem cells 2023 Aug 30;16(3):326-341
International journal of stem cells 2023 Aug 30;16(3):326-341
Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy.
Wan J, He Z, Peng R, Wu X, Zhu Z, Cui J, Hao X, Chen A, Zhang J, Cheng P
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Journal of nanobiotechnology 2023 Aug 21;21(1):284
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis.
Wang F, Guo K, Nan L, Wang S, Lu J, Wang Q, Ba Z, Huang Y, Wu D
Free radical biology & medicine 2023 Aug 1;204:128-150
Free radical biology & medicine 2023 Aug 1;204:128-150
Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis.
Chen S, Li Z, Chen D, Cui H, Wang J, Li Z, Li X, Zheng Z, Zhan Z, Liu H
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Annals of the rheumatic diseases 2023 Apr;82(4):533-545
Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation.
Liu L, Yu F, Chen L, Xia L, Wu C, Fang B
Advanced healthcare materials 2023 Apr;12(11):e2202390
Advanced healthcare materials 2023 Apr;12(11):e2202390
Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways.
Lu R, Wang YG, Qu Y, Wang SX, Peng C, You H, Zhu W, Chen A
Bone & joint research 2023 Apr 6;12(4):259-273
Bone & joint research 2023 Apr 6;12(4):259-273
miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/β-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2.
Ye P, Mi Z, Wei D, Gao P, Ma M, Yang H
Stem cells international 2022;2022:9455152
Stem cells international 2022;2022:9455152
Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a.
Zhou Y, Zheng T, Li L, Guo Y, Xiao J, Wang J, Du Z, Gao H, Tang W, Yang L, Hu H, Wang X, Meng M, Hou Z
Stem cells international 2022;2022:9124277
Stem cells international 2022;2022:9124277
Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration.
Yu XJ, Liu QK, Lu R, Wang SX, Xu HR, Wang YG, Bao Y, Jiang YQ, Li MW, Kang H
Oxidative medicine and cellular longevity 2022;2022:8983667
Oxidative medicine and cellular longevity 2022;2022:8983667
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Teng Y, Jin Z, Ren W, Lu M, Hou M, Zhou Q, Wang W, Yang H, Zou J
Oxidative medicine and cellular longevity 2022;2022:3047425
Oxidative medicine and cellular longevity 2022;2022:3047425
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression.
Zhang Q, Cao L, Zou S, Feng Y, Miao X, Huang L, Wu Y
Stem cells international 2022;2022:1157498
Stem cells international 2022;2022:1157498
A three-dimensional (3D), serum-free, Collagen Type I system for chondrogenesis of canine bone marrow-derived multipotent stromal cells (cMSCs).
MacIver MA, Dobson LK, Gregory CA, Muneoka K, Saunders WB
PloS one 2022;17(6):e0269571
PloS one 2022;17(6):e0269571
Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin.
Xiao J, Li Y, Cheng G, Xu G
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Open medicine (Warsaw, Poland) 2022;17(1):768-780
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.
Han H, Chen M, Li Z, Zhou S, Wu Y, Wei J
Drug design, development and therapy 2022;16:2627-2637
Drug design, development and therapy 2022;16:2627-2637
3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.
Tang H, Qin K, Wang A, Li S, Fang S, Gao W, Lu M, Huang W, Zhang H, Yin Z
Frontiers in pharmacology 2022;13:999851
Frontiers in pharmacology 2022;13:999851
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Jiang Z, Qi G, Lu W, Wang H, Li D, Chen W, Ding L, Yang X, Yuan H, Zeng Q
Frontiers in pharmacology 2022;13:952950
Frontiers in pharmacology 2022;13:952950
Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism.
Li XC, Luo SJ, Fan W, Zhou TL, Tan DQ, Tan RX, Xian QZ, Li J, Huang CM, Wang MS
Frontiers in immunology 2022;13:922173
Frontiers in immunology 2022;13:922173
Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration.
Hu Z, Wang Y, Gao X, Zhang Y, Liu C, Zhai Y, Chang X, Li H, Li Y, Lou J, Li C
Frontiers in pharmacology 2022;13:893307
Frontiers in pharmacology 2022;13:893307
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.
Wang Z, Zhang P, Zhao Y, Yu F, Wang S, Liu K, Cheng X, Shi J, He Q, Xia Y, Cheng L
Frontiers in bioengineering and biotechnology 2022;10:883118
Frontiers in bioengineering and biotechnology 2022;10:883118
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
Zhang Z, Huang Y, Xu N, Wang J, Yao T, Xu Y, Qiao D, Gao J, Shen S, Ma J
Frontiers in cell and developmental biology 2022;10:819262
Frontiers in cell and developmental biology 2022;10:819262
Chemically crosslinked hyaluronic acid-chitosan hydrogel for application on cartilage regeneration.
Escalante S, Rico G, Becerra J, San Román J, Vázquez-Lasa B, Aguilar MR, Durán I, García-Fernández L
Frontiers in bioengineering and biotechnology 2022;10:1058355
Frontiers in bioengineering and biotechnology 2022;10:1058355
MCP‑1/CCR2 axis inhibits the chondrogenic differentiation of human nucleus pulposus mesenchymal stem cells.
Ou X, Wen T, Ying J, He Q, Xuan A, Ruan D
Molecular medicine reports 2022 Sep;26(3)
Molecular medicine reports 2022 Sep;26(3)
Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.
Sheng R, Chen J, Wang H, Luo Y, Liu J, Chen Z, Mo Q, Chi J, Ling C, Tan X, Yao Q, Zhang W
Advanced healthcare materials 2022 Sep;11(17):e2200602
Advanced healthcare materials 2022 Sep;11(17):e2200602
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Zhang C, Li Z, Li L, Li S, Yang L, Chen L, Zhang X, Yang S, Guo Y
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Journal of orthopaedic surgery (Hong Kong) 2022 Sep-Dec;30(3):10225536221135474
Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.
Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420
Journal of nanobiotechnology 2022 Sep 19;20(1):420
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Zhu Y, Sun Y, Rui B, Lin J, Shen J, Xiao H, Liu X, Chai Y, Xu J, Yang Y
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.
Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Nagata K, Hojo H, Chang SH, Okada H, Yano F, Chijimatsu R, Omata Y, Mori D, Makii Y, Kawata M, Kaneko T, Iwanaga Y, Nakamoto H, Maenohara Y, Tachibana N, Ishikura H, Higuchi J, Taniguchi Y, Ohba S, Chung UI, Tanaka S, Saito T
Nature communications 2022 Oct 19;13(1):6187
Nature communications 2022 Oct 19;13(1):6187
Disrupted tenogenesis in masseter as a potential cause of micrognathia.
Liu C, Zhou N, Li N, Xu T, Chen X, Zhou H, Xie A, Liu H, Zhu L, Wang S, Xiao J
International journal of oral science 2022 Oct 18;14(1):50
International journal of oral science 2022 Oct 18;14(1):50
Scavenging of reactive oxygen species can adjust the differentiation of tendon stem cells and progenitor cells and prevent ectopic calcification in tendinopathy.
Shen H, Cheng L, Zheng Q, Liu W, Wang Y
Acta biomaterialia 2022 Oct 15;152:440-452
Acta biomaterialia 2022 Oct 15;152:440-452
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.
Yang L, Yu C, Fan X, Zeng T, Yang W, Xia J, Wang J, Yao L, Hu C, Jin Y, Zhu Y, Chen J, Hu Z
Journal of nanobiotechnology 2022 Oct 1;20(1):433
Journal of nanobiotechnology 2022 Oct 1;20(1):433
Extracellular vesicles derived from mesenchymal stem cells confer protection against intervertebral disc degeneration through a microRNA-217-dependent mechanism.
Hao Y, Zhu G, Yu L, Ren Z, Zhang P, Zhu J, Cao S
Osteoarthritis and cartilage 2022 Nov;30(11):1455-1467
Osteoarthritis and cartilage 2022 Nov;30(11):1455-1467
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Yi Y, Yang N, Yang Z, Tao X, Li Y
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Orthopaedic surgery 2022 Nov;14(11):3078-3091
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Liu X, Zhao J, Jiang H, Li H, Feng Y, Ke J, Long X
Journal of dental research 2022 Nov;101(12):1499-1509
Journal of dental research 2022 Nov;101(12):1499-1509
USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3.
Hai B, Mao T, Du C, Jia F, Liu Y, Song Q, Pan X, Liu X, Zhu B
Acta biochimica et biophysica Sinica 2022 Nov 25;54(11):1720 - 1730
Acta biochimica et biophysica Sinica 2022 Nov 25;54(11):1720 - 1730
Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.
Li G, Deng Y, Li K, Liu Y, Wang L, Wu Z, Chen C, Zhang K, Yu B
Antioxidants (Basel, Switzerland) 2022 Nov 16;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 16;11(11)
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model.
Hong JY, Kim H, Jeon WJ, Lee J, Yeo C, Lee YJ, Ha IH
Cells 2022 Nov 10;11(22)
Cells 2022 Nov 10;11(22)
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Kim HR, Choi H, Park SY, Song YC, Kim JH, Shim S, Jun W, Kim KJ, Han J, Chi SW, Leem SH, Chung JW
BMB reports 2022 May;55(5):226-231
BMB reports 2022 May;55(5):226-231
MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.
Chen S, Shi G, Zeng J, Li PH, Peng Y, Ding Z, Cao HQ, Zheng R, Wang W
Human cell 2022 May;35(3):779-791
Human cell 2022 May;35(3):779-791
MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2.
Liu J, Tang G, Liu W, Zhou Y, Fan C, Zhang W
Bioengineered 2022 May;13(5):13801-13814
Bioengineered 2022 May;13(5):13801-13814
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Liu L, Zhao C, Zhang H, Lu Y, Luo B, Yao Z, Shao Y, Zeng H, Zeng C, Zhang R, Fang H, Pan J, Bai X, Cai D
Rheumatology (Oxford, England) 2022 May 30;61(6):2631-2643
Rheumatology (Oxford, England) 2022 May 30;61(6):2631-2643
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.
Dai WY, Luo ZP
Cellular signalling 2022 Mar;91:110243
Cellular signalling 2022 Mar;91:110243
Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.
Wang J, Xia D, Lin Y, Xu W, Wu Y, Chen J, Chu J, Shen P, Weng S, Wang X, Shen L, Fan S, Shen S
Experimental & molecular medicine 2022 Mar;54(3):285-297
Experimental & molecular medicine 2022 Mar;54(3):285-297
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1β in vitro.
Yu H, Liu Y, Yang X, He J, Zhong Q, Guo X
Experimental and therapeutic medicine 2022 Mar;23(3):208
Experimental and therapeutic medicine 2022 Mar;23(3):208
Phenotypic and functional properties of dedifferentiated fat cells derived from infrapatellar fat pad.
Tanimoto K, Matsumoto T, Nagaoka Y, Kazama T, Yamamoto C, Kano K, Nagaoka M, Saito S, Tokuhashi Y, Nakanishi K
Regenerative therapy 2022 Mar;19:35-46
Regenerative therapy 2022 Mar;19:35-46
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration.
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP, Ma X, Wang X, Gartland A, Wang N, Shah KM, Zhang H, Cao X, Yang L, Liu M, Luo J
Cell discovery 2022 Mar 8;8(1):24
Cell discovery 2022 Mar 8;8(1):24
Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture.
Ito S, Kasahara N, Kitamura K, Matsunaga S, Mizoguchi T, Htun MW, Shibata Y, Abe S, Takano M, Yamaguchi A
Bone reports 2022 Jun;16:101522
Bone reports 2022 Jun;16:101522
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
Dong J, Zhang KJ, Li GC, Chen XR, Lin JJ, Li JW, Lv ZY, Deng ZZ, Dai J, Cao W, Jiang Q
Acta pharmacologica Sinica 2022 Jul;43(7):1793-1802
Acta pharmacologica Sinica 2022 Jul;43(7):1793-1802
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Zhong H, Zhou Z, Guo L, Liu FS, Wang X, Li J, Lv GH, Zou MX
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.
Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z, Wang J, Li Y, Liu J, Duan A, Liu F
Stem cell research & therapy 2022 Jul 16;13(1):322
Stem cell research & therapy 2022 Jul 16;13(1):322
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Cadherin-11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure.
Li J, Cao R, Wang Q, Shi H, Wu Y, Sun K, Liu X, Jiang H
Journal of tissue engineering and regenerative medicine 2022 Feb;16(2):188-199
Journal of tissue engineering and regenerative medicine 2022 Feb;16(2):188-199
Glucocorticoid caused lactic acid accumulation and damage in human chondrocytes via ROS-mediated inhibition of Monocarboxylate Transporter 4.
Li Q, Chen H, Li Z, Zhang F, Chen L
Bone 2022 Feb;155:116299
Bone 2022 Feb;155:116299
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Bioprinted living tissue constructs with layer-specific, growth factor-loaded microspheres for improved enthesis healing of a rotator cuff.
Bai L, Han Q, Meng Z, Chen B, Qu X, Xu M, Su Y, Qiu Z, Xue Y, He J, Zhang J, Yin Z
Acta biomaterialia 2022 Dec;154:275-289
Acta biomaterialia 2022 Dec;154:275-289
An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.
Cheng H, Guo Q, Zhao H, Liu K, Kang H, Gao F, Guo J, Yuan X, Hu S, Li F, Yang Q, Fang Z
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells.
Takao T, Yamada D, Takarada T
STAR protocols 2022 Dec 16;3(4):101786
STAR protocols 2022 Dec 16;3(4):101786
Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells.
Chen W, Yasen M, Wang H, Zhuang C, Wang Z, Lu S, Jiang L, Lin H
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
BMC pharmacology & toxicology 2022 Dec 1;23(1):90
DDIT3/CHOP mediates the inhibitory effect of ER stress on chondrocyte differentiation by AMPKα-SIRT1 pathway.
Yu X, Xu X, Dong W, Yang C, Luo Y, He Y, Jiang C, Wu Y, Wang J
Biochimica et biophysica acta. Molecular cell research 2022 Aug;1869(8):119265
Biochimica et biophysica acta. Molecular cell research 2022 Aug;1869(8):119265
Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.
Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C
Cell death & disease 2022 Aug 9;13(8):695
Cell death & disease 2022 Aug 9;13(8):695
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Huang H, Ding X, Xing D, Lin J, Li Z, Lin J
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration.
Peng P, Wang D, Xu X, Wang D, Gao B, Wang H, Jia H, Shang Q, Zheng C, Gao C, Mao J, Luo Z, Yang L, Hu X
Arthritis research & therapy 2022 Aug 3;24(1):181
Arthritis research & therapy 2022 Aug 3;24(1):181
Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12/AKT/β-catenin axis.
Zeng Z, Dai Y, Deng S, Zou S, Dou T, Wei F
Immunopharmacology and immunotoxicology 2022 Apr;44(2):247-260
Immunopharmacology and immunotoxicology 2022 Apr;44(2):247-260
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Shen K, Duan A, Cheng J, Yuan T, Zhou J, Song H, Chen Z, Wan B, Liu J, Zhang X, Zhang Y, Xie R, Liu F, Fan W, Zuo Q
Acta biomaterialia 2022 Apr 15;143:173-188
Acta biomaterialia 2022 Apr 15;143:173-188
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
Zhang S, Liang W, Abulizi Y, Xu T, Cao R, Xun C, Zhang J, Sheng W
BioMed research international 2021;2021:6631562
BioMed research international 2021;2021:6631562
1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.
Duan A, Ma Z, Liu W, Shen K, Zhou H, Wang S, Kong R, Shao Y, Chen Y, Guo W, Liu F
Journal of inflammation research 2021;14:6523-6542
Journal of inflammation research 2021;14:6523-6542
Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.
Lu R, Yu X, Liang S, Cheng P, Wang Z, He ZY, Lv ZT, Wan J, Mo H, Zhu WT, Chen AM
Frontiers in pharmacology 2021;12:761922
Frontiers in pharmacology 2021;12:761922
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Li L, Wei K, Ding Y, Ahati P, Xu H, Fang H, Wang H
Frontiers in immunology 2021;12:666361
Frontiers in immunology 2021;12:666361
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.
Zheng Q, Shen H, Tong Z, Cheng L, Xu Y, Feng Z, Liao S, Hu X, Pan Z, Mao Z, Wang Y
Theranostics 2021;11(1):147-163
Theranostics 2021;11(1):147-163
Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease.
Cheng B, Liang C, Yang X, Li P, Liu L, Cheng S, Jia Y, Zhang L, Ma M, Qi X, Yao Y, Chu X, Ye J, Lu C, Guo X, Wen Y, Zhang F
Bone 2021 Sep;150:115997
Bone 2021 Sep;150:115997
Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration.
Cha S, Lee SM, Wang J, Zhao Q, Bai D
International journal of molecular sciences 2021 Sep 30;22(19)
International journal of molecular sciences 2021 Sep 30;22(19)
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
Samara VA, Das S, Reddy MA, Tanwar VS, Stapleton K, Leung A, Abdollahi M, Ganguly R, Lanting L, Natarajan R
Cells 2021 Oct 9;10(10)
Cells 2021 Oct 9;10(10)
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360
Autophagy 2021 Nov;17(11):3338-3360
Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.
Fang L, Ye Y, Tan X, Huang L, He Y
Annals of the New York Academy of Sciences 2021 Nov;1503(1):72-87
Annals of the New York Academy of Sciences 2021 Nov;1503(1):72-87
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Yang Q, Guo J, Ren Z, Li B, Huang H, Yang Z
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.
Shen PC, Lu CC, Chou SH, Liu ZM, Su SJ, Tien YC
Biomedicines 2021 Nov 30;9(12)
Biomedicines 2021 Nov 30;9(12)
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Liu H, Rui Y, Liu J, Gao F, Jin Y
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.
Wang H, Li Z, Huo Y, Tian T, Yang D, Ma L, Yang S, Ding W
Life sciences 2021 Nov 1;284:119874
Life sciences 2021 Nov 1;284:119874
AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling.
Wang B, Jiang B, Li Y, Dai Y, Li P, Li L, Xu J, Li L, Wu P
Bone 2021 May;146:115875
Bone 2021 May;146:115875
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway.
Yu H, Liu Y, Yang X, He J, Zhang F, Zhong Q, Guo X
Stem cell research & therapy 2021 May 20;12(1):296
Stem cell research & therapy 2021 May 20;12(1):296
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease.
Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramírez-Jarquín UN, Florescu K, Hernandez J, Subramaniam S
Nature communications 2021 Mar 5;12(1):1461
Nature communications 2021 Mar 5;12(1):1461
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Fabrication of 3D-Printed Interpenetrating Hydrogel Scaffolds for Promoting Chondrogenic Differentiation.
Guan J, Yuan FZ, Mao ZM, Zhu HL, Lin L, Chen HH, Yu JK
Polymers 2021 Jun 29;13(13)
Polymers 2021 Jun 29;13(13)
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Sun J, Xing F, Zou M, Gong M, Li L, Xiang Z
Stem cell research & therapy 2021 Jun 28;12(1):366
Stem cell research & therapy 2021 Jun 28;12(1):366
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.
Wang X, Wu H, Zhang Q, Liu F, Wang J, Wei C, Liu F, Li J
Mechanisms of ageing and development 2021 Jul;197:111511
Mechanisms of ageing and development 2021 Jul;197:111511
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
Hu Y, Li X, Zhi X, Cong W, Huang B, Chen H, Wang Y, Li Y, Wang L, Fang C, Guo J, Liu Y, Cui J, Cao L, Weng W, Zhou Q, Wang S, Chen X, Su J
EMBO reports 2021 Jul 5;22(7):e52481
EMBO reports 2021 Jul 5;22(7):e52481
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
Duan A, Shen K, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, Guo W, Wang X, Xue T, Li L, Huang X, Sun Y, Cai Z, Liu W, Liu F
Stem cell research & therapy 2021 Jul 28;12(1):427
Stem cell research & therapy 2021 Jul 28;12(1):427
microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.
Cui S, Zhang L
Journal of tissue engineering 2021 Jan-Dec;12:20417314211021679
Journal of tissue engineering 2021 Jan-Dec;12:20417314211021679
In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.
Niu YT, Xie L, Deng RR, Zhang XY
BMC complementary medicine and therapies 2021 Jan 14;21(1):32
BMC complementary medicine and therapies 2021 Jan 14;21(1):32
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
Wang F, Ma L, Ding Y, He L, Chang M, Shan Y, Siwko S, Chen G, Liu Y, Jin Y, Peng X, Luo J
Pharmacological research 2021 Feb;164:105406
Pharmacological research 2021 Feb;164:105406
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.
Dong X, Xu X, Yang C, Luo Y, Wu Y, Wang J
Bone 2021 Feb;143:115714
Bone 2021 Feb;143:115714
Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway.
Shen PC, Chou SH, Lu CC, Huang HT, Chien SH, Huang PJ, Liu ZM, Shih CL, Su SJ, Chen LM, Tien YC
Cartilage 2021 Dec;13(2_suppl):238S-253S
Cartilage 2021 Dec;13(2_suppl):238S-253S
Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.
Takahashi I, Matsuzaki T, Kuroki H, Hoso M
Cartilage 2021 Dec;13(2_suppl):1530S-1539S
Cartilage 2021 Dec;13(2_suppl):1530S-1539S
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ
Cartilage 2021 Dec;13(1_suppl):818S-828S
Cartilage 2021 Dec;13(1_suppl):818S-828S
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723
Aging 2021 Apr 6;13(7):10703-10723
CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.
Xiang Q, Kang L, Zhao K, Wang J, Hua W, Song Y, Feng X, Li G, Lu S, Wang K, Yang C, Zhang Y
Frontiers in cell and developmental biology 2020;8:581941
Frontiers in cell and developmental biology 2020;8:581941
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
SIRT4 suppresses the inflammatory response and oxidative stress in osteoarthritis.
Dai Y, Liu S, Li J, Li J, Lan Y, Nie H, Zuo Y
American journal of translational research 2020;12(5):1965-1975
American journal of translational research 2020;12(5):1965-1975
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.
Zhao Y, Qiu C, Wang W, Peng J, Cheng X, Shangguan Y, Xu M, Li J, Qu R, Chen X, Jia S, Luo D, Liu L, Li P, Guo F, Vasilev K, Liu L, Hayball J, Dong S, Pan X, Li Y, Guo L, Cheng L, Li W
Theranostics 2020;10(15):7015-7033
Theranostics 2020;10(15):7015-7033
miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.
Zhang M, Yuan SZ, Sun H, Sun L, Zhou D, Yan J
Journal of tissue engineering and regenerative medicine 2020 Nov;14(11):1618-1629
Journal of tissue engineering and regenerative medicine 2020 Nov;14(11):1618-1629
CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, Wang K, Yang C, Zhang Y
EBioMedicine 2020 Mar;53:102679
EBioMedicine 2020 Mar;53:102679
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries.
Collins LN, Brunjes PC
The Journal of comparative neurology 2020 Mar 1;528(4):637-649
The Journal of comparative neurology 2020 Mar 1;528(4):637-649
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration.
Hu H, Dong L, Bu Z, Shen Y, Luo J, Zhang H, Zhao S, Lv F, Liu Z
Journal of extracellular vesicles 2020 Jun 16;9(1):1778883
Journal of extracellular vesicles 2020 Jun 16;9(1):1778883
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis.
Chen Y, Guo H, Li L, Bao D, Gao F, Li Q, Huang Q, Duan X, Xiang Z
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 9;26:e923868
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 9;26:e923868
Knockdown of SGK1 alleviates the IL-1β-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes.
Huang W, Cheng C, Shan WS, Ding ZF, Liu FE, Lu W, He W, Xu JG, Yin ZS
The FEBS journal 2020 Jan;287(1):94-107
The FEBS journal 2020 Jan;287(1):94-107
An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration.
Zhang W, Ling C, Zhang A, Liu H, Jiang Y, Li X, Sheng R, Yao Q, Chen J
Bioactive materials 2020 Dec;5(4):832-843
Bioactive materials 2020 Dec;5(4):832-843
Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects.
Zhang W, Ling C, Li X, Sheng R, Liu H, Zhang A, Jiang Y, Chen J, Yao Q
ACS biomaterials science & engineering 2020 Dec 14;6(12):6917-6925
ACS biomaterials science & engineering 2020 Dec 14;6(12):6917-6925
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.
Ge J, Cheng X, Yan Q, Wu C, Wang Y, Yu H, Yang H, Zhou F, Zou J
Journal of cellular and molecular medicine 2020 Aug;24(15):8650-8661
Journal of cellular and molecular medicine 2020 Aug;24(15):8650-8661
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
Teng Y, Ni G, Zhang W, Hua J, Sun L, Zheng M, Dong Q, Huang W
Biochemical and biophysical research communications 2020 Aug 13;529(1):28-34
Biochemical and biophysical research communications 2020 Aug 13;529(1):28-34
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Bai Z, Liu W, He D, Wang Y, Yi W, Luo C, Shen J, Hu Z
Aging 2020 Apr 22;12(8):7534-7548
Aging 2020 Apr 22;12(8):7534-7548
Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
Huang J, Chen C, Liang C, Luo P, Xia G, Zhang L, Wang X, Wen Z, Cao X, Wu S
Stem cells and development 2020 Apr 1;29(7):401-413
Stem cells and development 2020 Apr 1;29(7):401-413
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267
Theranostics 2019;9(8):2252-2267
Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration.
Zhang S, Hu P, Liu T, Li Z, Huang Y, Liao J, Hamid MR, Wen L, Wang T, Mo C, Alini M, Grad S, Wang T, Chen D, Zhou G
Theranostics 2019;9(24):7108-7121
Theranostics 2019;9(24):7108-7121
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration.
Kang L, Xiang Q, Zhan S, Song Y, Wang K, Zhao K, Li S, Shao Z, Yang C, Zhang Y
Oxidative medicine and cellular longevity 2019;2019:7810320
Oxidative medicine and cellular longevity 2019;2019:7810320
Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation.
Pang HL, Zhao QQ, Ma Y, Song YL, Min J, Lu JR, Li H, Zhao DQ
Stem cells international 2019;2019:2139814
Stem cells international 2019;2019:2139814
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
Sun JC, Zheng B, Sun RX, Meng YK, Wang SM, Yang HS, Chen Y, Shi JG, Guo YF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136
Bone 2019 Jun;123:129-136
Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis.
Li Y, Feng Y, Cao P, Ke J, Fang W, Cai H, Deng M, Long X
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):79-86
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):79-86
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats.
Wang W, Wang Y, Deng G, Ma J, Huang X, Yu J, Xi Y, Ye X
Stem cells international 2018;2018:7564159
Stem cells international 2018;2018:7564159
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration.
Wang W, Deng G, Qiu Y, Huang X, Xi Y, Yu J, Yang X, Ye X
International journal of molecular medicine 2018 May;41(5):2553-2564
International journal of molecular medicine 2018 May;41(5):2553-2564
Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits.
Yang SW, Ku KC, Chen SY, Kuo SM, Chen IF, Wang TY, Chang SJ
Journal of biomaterials applications 2018 Jan;32(6):800-812
Journal of biomaterials applications 2018 Jan;32(6):800-812
Normobaric oxygen therapy increases cartilage survival ratio in auricular composite grafting in rat models.
Hamamoto Y, Nagasao T, Aizezi N, Tamai M, Kogure T, Morotomi T, Tagichi N, Tanaka Y
JPRAS open 2018 Dec;18:28-37
JPRAS open 2018 Dec;18:28-37
Leukemia inhibitory factor promotes extracellular matrix synthesis in degenerative nucleus pulposus cells via MAPK-ERK1/2 signaling pathway.
Zhou H, Shen J, Hu Z, Zhong X
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):253-259
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):253-259
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230
International immunopharmacology 2018 Aug;61:222-230
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress.
Yan J, Guo Y, Fei Y, Zhang R, Han Y, Lu S
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):110-118
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):110-118
Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin.
Balogh E, Tolnai E, Nagy B Jr, Nagy B, Balla G, Balla J, Jeney V
Biochimica et biophysica acta 2016 Sep;1862(9):1640-9
Biochimica et biophysica acta 2016 Sep;1862(9):1640-9
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells.
Yan J, Fei Y, Han Y, Lu S
Cell biology international 2016 Oct;40(10):1033-40
Cell biology international 2016 Oct;40(10):1033-40
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S
Experimental cell research 2016 May 15;344(1):67-75
Experimental cell research 2016 May 15;344(1):67-75
Ancient origin of lubricated joints in bony vertebrates.
Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis NA, Postlethwait J, Miller CT, Crump JG
eLife 2016 Jul 19;5
eLife 2016 Jul 19;5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Aggrecan antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aggrecan. This antibody recognizes human,mouse,rat antigen. The Aggrecan antibody has been validated for the following applications: ELISA, WB, IHC analysis.
