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- References [81]
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- Product number
- 13880-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13880-1-AP, RRID:AB_2722780
- Product name
- Aggrecan antibody
- Antibody type
- Polyclonal
- Description
- Aggrecan antibody (Cat. #13880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.
Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease.
Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration.
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Cadherin-11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure.
17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.
AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Fabrication of 3D-Printed Interpenetrating Hydrogel Scaffolds for Promoting Chondrogenic Differentiation.
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.
In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
SIRT4 suppresses the inflammatory response and oxidative stress in osteoarthritis.
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.
miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.
CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration.
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis.
Knockdown of SGK1 alleviates the IL-1β-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes.
An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration.
Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration.
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration.
Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats.
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration.
Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits.
Normobaric oxygen therapy increases cartilage survival ratio in auricular composite grafting in rat models.
Leukemia inhibitory factor promotes extracellular matrix synthesis in degenerative nucleus pulposus cells via MAPK-ERK1/2 signaling pathway.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress.
Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin.
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells.
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Ancient origin of lubricated joints in bony vertebrates.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
Zhang S, Liang W, Abulizi Y, Xu T, Cao R, Xun C, Zhang J, Sheng W
BioMed research international 2021;2021:6631562
BioMed research international 2021;2021:6631562
M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
Li L, Wei K, Ding Y, Ahati P, Xu H, Fang H, Wang H
Frontiers in immunology 2021;12:666361
Frontiers in immunology 2021;12:666361
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.
Zheng Q, Shen H, Tong Z, Cheng L, Xu Y, Feng Z, Liao S, Hu X, Pan Z, Mao Z, Wang Y
Theranostics 2021;11(1):147-163
Theranostics 2021;11(1):147-163
Genetic association scan of 32 osteoarthritis susceptibility genes identified TP63 associated with an endemic osteoarthritis, Kashin-Beck disease.
Cheng B, Liang C, Yang X, Li P, Liu L, Cheng S, Jia Y, Zhang L, Ma M, Qi X, Yao Y, Chu X, Ye J, Lu C, Guo X, Wen Y, Zhang F
Bone 2021 Sep;150:115997
Bone 2021 Sep;150:115997
Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration.
Cha S, Lee SM, Wang J, Zhao Q, Bai D
International journal of molecular sciences 2021 Sep 30;22(19)
International journal of molecular sciences 2021 Sep 30;22(19)
Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.
Liu L, Zhao C, Zhang H, Lu Y, Luo B, Yao Z, Shao Y, Zeng H, Zeng C, Zhang R, Fang H, Pan J, Bai X, Cai D
Rheumatology (Oxford, England) 2021 Sep 24;
Rheumatology (Oxford, England) 2021 Sep 24;
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
Samara VA, Das S, Reddy MA, Tanwar VS, Stapleton K, Leung A, Abdollahi M, Ganguly R, Lanting L, Natarajan R
Cells 2021 Oct 9;10(10)
Cells 2021 Oct 9;10(10)
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360
Autophagy 2021 Nov;17(11):3338-3360
Overloading stress-induced progressive degeneration and self-repair in condylar cartilage.
Fang L, Ye Y, Tan X, Huang L, He Y
Annals of the New York Academy of Sciences 2021 Nov;1503(1):72-87
Annals of the New York Academy of Sciences 2021 Nov;1503(1):72-87
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2021 Nov 9;
Journal of bone and mineral metabolism 2021 Nov 9;
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy.
Dong J, Zhang KJ, Li GC, Chen XR, Lin JJ, Li JW, Lv ZY, Deng ZZ, Dai J, Cao W, Jiang Q
Acta pharmacologica Sinica 2021 Nov 9;
Acta pharmacologica Sinica 2021 Nov 9;
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Yang Q, Guo J, Ren Z, Li B, Huang H, Yang Z
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Liu H, Rui Y, Liu J, Gao F, Jin Y
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Cadherin-11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure.
Li J, Cao R, Wang Q, Shi H, Wu Y, Sun K, Liu X, Jiang H
Journal of tissue engineering and regenerative medicine 2021 Nov 26;
Journal of tissue engineering and regenerative medicine 2021 Nov 26;
17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.
Wang H, Li Z, Huo Y, Tian T, Yang D, Ma L, Yang S, Ding W
Life sciences 2021 Nov 1;284:119874
Life sciences 2021 Nov 1;284:119874
AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling.
Wang B, Jiang B, Li Y, Dai Y, Li P, Li L, Xu J, Li L, Wu P
Bone 2021 May;146:115875
Bone 2021 May;146:115875
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway.
Yu H, Liu Y, Yang X, He J, Zhang F, Zhong Q, Guo X
Stem cell research & therapy 2021 May 20;12(1):296
Stem cell research & therapy 2021 May 20;12(1):296
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Fabrication of 3D-Printed Interpenetrating Hydrogel Scaffolds for Promoting Chondrogenic Differentiation.
Guan J, Yuan FZ, Mao ZM, Zhu HL, Lin L, Chen HH, Yu JK
Polymers 2021 Jun 29;13(13)
Polymers 2021 Jun 29;13(13)
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Sun J, Xing F, Zou M, Gong M, Li L, Xiang Z
Stem cell research & therapy 2021 Jun 28;12(1):366
Stem cell research & therapy 2021 Jun 28;12(1):366
NFKB2 inhibits NRG1 transcription to affect nucleus pulposus cell degeneration and inflammation in intervertebral disc degeneration.
Wang X, Wu H, Zhang Q, Liu F, Wang J, Wei C, Liu F, Li J
Mechanisms of ageing and development 2021 Jul;197:111511
Mechanisms of ageing and development 2021 Jul;197:111511
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.
Hu Y, Li X, Zhi X, Cong W, Huang B, Chen H, Wang Y, Li Y, Wang L, Fang C, Guo J, Liu Y, Cui J, Cao L, Weng W, Zhou Q, Wang S, Chen X, Su J
EMBO reports 2021 Jul 5;22(7):e52481
EMBO reports 2021 Jul 5;22(7):e52481
microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation.
Cui S, Zhang L
Journal of tissue engineering 2021 Jan-Dec;12:20417314211021679
Journal of tissue engineering 2021 Jan-Dec;12:20417314211021679
In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells.
Niu YT, Xie L, Deng RR, Zhang XY
BMC complementary medicine and therapies 2021 Jan 14;21(1):32
BMC complementary medicine and therapies 2021 Jan 14;21(1):32
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
Wang F, Ma L, Ding Y, He L, Chang M, Shan Y, Siwko S, Chen G, Liu Y, Jin Y, Peng X, Luo J
Pharmacological research 2021 Feb;164:105406
Pharmacological research 2021 Feb;164:105406
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis.
Dong X, Xu X, Yang C, Luo Y, Wu Y, Wang J
Bone 2021 Feb;143:115714
Bone 2021 Feb;143:115714
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Lei J, Deng H, Ran Y, Lv Y, Amhare AF, Wang L, Guo X, Han J, Lammi MJ
Cartilage 2021 Dec;13(1_suppl):818S-828S
Cartilage 2021 Dec;13(1_suppl):818S-828S
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.
Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Arthritis & rheumatology (Hoboken, N.J.) 2021 Aug;73(8):1441-1450
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723
Aging 2021 Apr 6;13(7):10703-10723
CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.
Xiang Q, Kang L, Zhao K, Wang J, Hua W, Song Y, Feng X, Li G, Lu S, Wang K, Yang C, Zhang Y
Frontiers in cell and developmental biology 2020;8:581941
Frontiers in cell and developmental biology 2020;8:581941
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
SIRT4 suppresses the inflammatory response and oxidative stress in osteoarthritis.
Dai Y, Liu S, Li J, Li J, Lan Y, Nie H, Zuo Y
American journal of translational research 2020;12(5):1965-1975
American journal of translational research 2020;12(5):1965-1975
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.
Zhao Y, Qiu C, Wang W, Peng J, Cheng X, Shangguan Y, Xu M, Li J, Qu R, Chen X, Jia S, Luo D, Liu L, Li P, Guo F, Vasilev K, Liu L, Hayball J, Dong S, Pan X, Li Y, Guo L, Cheng L, Li W
Theranostics 2020;10(15):7015-7033
Theranostics 2020;10(15):7015-7033
miR-199b-5p promoted chondrogenic differentiation of C3H10T1/2 cells by regulating JAG1.
Zhang M, Yuan SZ, Sun H, Sun L, Zhou D, Yan J
Journal of tissue engineering and regenerative medicine 2020 Nov;14(11):1618-1629
Journal of tissue engineering and regenerative medicine 2020 Nov;14(11):1618-1629
CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, Wang K, Yang C, Zhang Y
EBioMedicine 2020 Mar;53:102679
EBioMedicine 2020 Mar;53:102679
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries.
Collins LN, Brunjes PC
The Journal of comparative neurology 2020 Mar 1;528(4):637-649
The Journal of comparative neurology 2020 Mar 1;528(4):637-649
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
miR-23a-3p-abundant small extracellular vesicles released from Gelma/nanoclay hydrogel for cartilage regeneration.
Hu H, Dong L, Bu Z, Shen Y, Luo J, Zhang H, Zhao S, Lv F, Liu Z
Journal of extracellular vesicles 2020 Jun 16;9(1):1778883
Journal of extracellular vesicles 2020 Jun 16;9(1):1778883
Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis.
Chen Y, Guo H, Li L, Bao D, Gao F, Li Q, Huang Q, Duan X, Xiang Z
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 9;26:e923868
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 9;26:e923868
Knockdown of SGK1 alleviates the IL-1β-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes.
Huang W, Cheng C, Shan WS, Ding ZF, Liu FE, Lu W, He W, Xu JG, Yin ZS
The FEBS journal 2020 Jan;287(1):94-107
The FEBS journal 2020 Jan;287(1):94-107
An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration.
Zhang W, Ling C, Zhang A, Liu H, Jiang Y, Li X, Sheng R, Yao Q, Chen J
Bioactive materials 2020 Dec;5(4):832-843
Bioactive materials 2020 Dec;5(4):832-843
Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects.
Zhang W, Ling C, Li X, Sheng R, Liu H, Zhang A, Jiang Y, Chen J, Yao Q
ACS biomaterials science & engineering 2020 Dec 14;6(12):6917-6925
ACS biomaterials science & engineering 2020 Dec 14;6(12):6917-6925
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.
Ge J, Cheng X, Yan Q, Wu C, Wang Y, Yu H, Yang H, Zhou F, Zou J
Journal of cellular and molecular medicine 2020 Aug;24(15):8650-8661
Journal of cellular and molecular medicine 2020 Aug;24(15):8650-8661
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
Teng Y, Ni G, Zhang W, Hua J, Sun L, Zheng M, Dong Q, Huang W
Biochemical and biophysical research communications 2020 Aug 13;529(1):28-34
Biochemical and biophysical research communications 2020 Aug 13;529(1):28-34
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells.
Bai Z, Liu W, He D, Wang Y, Yi W, Luo C, Shen J, Hu Z
Aging 2020 Apr 22;12(8):7534-7548
Aging 2020 Apr 22;12(8):7534-7548
Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
Huang J, Chen C, Liang C, Luo P, Xia G, Zhang L, Wang X, Wen Z, Cao X, Wu S
Stem cells and development 2020 Apr 1;29(7):401-413
Stem cells and development 2020 Apr 1;29(7):401-413
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267
Theranostics 2019;9(8):2252-2267
Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration.
Zhang S, Hu P, Liu T, Li Z, Huang Y, Liao J, Hamid MR, Wen L, Wang T, Mo C, Alini M, Grad S, Wang T, Chen D, Zhou G
Theranostics 2019;9(24):7108-7121
Theranostics 2019;9(24):7108-7121
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration.
Kang L, Xiang Q, Zhan S, Song Y, Wang K, Zhao K, Li S, Shao Z, Yang C, Zhang Y
Oxidative medicine and cellular longevity 2019;2019:7810320
Oxidative medicine and cellular longevity 2019;2019:7810320
Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation.
Pang HL, Zhao QQ, Ma Y, Song YL, Min J, Lu JR, Li H, Zhao DQ
Stem cells international 2019;2019:2139814
Stem cells international 2019;2019:2139814
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
Sun JC, Zheng B, Sun RX, Meng YK, Wang SM, Yang HS, Chen Y, Shi JG, Guo YF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108652
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M
Bone 2019 Jun;123:129-136
Bone 2019 Jun;123:129-136
Role of synovium-derived fibrous cartilage in temporomandibular joint synovial chondromatosis.
Li Y, Feng Y, Cao P, Ke J, Fang W, Cai H, Deng M, Long X
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):79-86
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2019 Jan;48(1):79-86
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats.
Wang W, Wang Y, Deng G, Ma J, Huang X, Yu J, Xi Y, Ye X
Stem cells international 2018;2018:7564159
Stem cells international 2018;2018:7564159
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, Tian N, Fan P, Pan X, Xu D, Hu J, Zhou Y, Wang X, Zhang X
International journal of biological sciences 2018;14(13):1873-1882
International journal of biological sciences 2018;14(13):1873-1882
Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration.
Wang W, Deng G, Qiu Y, Huang X, Xi Y, Yu J, Yang X, Ye X
International journal of molecular medicine 2018 May;41(5):2553-2564
International journal of molecular medicine 2018 May;41(5):2553-2564
Development of chondrocyte-seeded electrosprayed nanoparticles for repair of articular cartilage defects in rabbits.
Yang SW, Ku KC, Chen SY, Kuo SM, Chen IF, Wang TY, Chang SJ
Journal of biomaterials applications 2018 Jan;32(6):800-812
Journal of biomaterials applications 2018 Jan;32(6):800-812
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JPRAS open 2018 Dec;18:28-37
JPRAS open 2018 Dec;18:28-37
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Zhou H, Shen J, Hu Z, Zhong X
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):253-259
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):253-259
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Ding QH, Ye CY, Chen EM, Zhang W, Wang XH
International immunopharmacology 2018 Aug;61:222-230
International immunopharmacology 2018 Aug;61:222-230
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress.
Yan J, Guo Y, Fei Y, Zhang R, Han Y, Lu S
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):110-118
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):110-118
Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin.
Balogh E, Tolnai E, Nagy B Jr, Nagy B, Balla G, Balla J, Jeney V
Biochimica et biophysica acta 2016 Sep;1862(9):1640-9
Biochimica et biophysica acta 2016 Sep;1862(9):1640-9
Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells.
Yan J, Fei Y, Han Y, Lu S
Cell biology international 2016 Oct;40(10):1033-40
Cell biology international 2016 Oct;40(10):1033-40
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S
Experimental cell research 2016 May 15;344(1):67-75
Experimental cell research 2016 May 15;344(1):67-75
Ancient origin of lubricated joints in bony vertebrates.
Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis NA, Postlethwait J, Miller CT, Crump JG
eLife 2016 Jul 19;5
eLife 2016 Jul 19;5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Aggrecan antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Aggrecan. This antibody recognizes human,mouse,rat antigen. The Aggrecan antibody has been validated for the following applications: ELISA, WB, IHC analysis.
