Tissue expression
Cell line expression
Protein structure
CFD
Complement factor DADN, DF, PFD
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Top validated antibodies |
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Invitrogen Antibodies | PA5-79035 | 1 references | Polyclonal |
WB
IHC
OA
|
|
antibodies-online | ABIN2192403 | 2 references | Monoclonal |
WB
EL |
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Novus Biologicals | AF5430 | 4 references | Polyclonal |
WB
IP |
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R&D Systems | AF5430 | 3 references | Polyclonal |
WB
IP |
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Biorbyt | orb456831 | Polyclonal |
WB
EL
ICC
IHC |
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Enhanced validation
Supportive data in Antibodypedia
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider