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Protein structure
CFD
Complement factor DADN, DF, PFD
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-79035 |
1 references | Polyclonal |
WB
IHC
OA
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| antibodies-online | ABIN2192403 |
2 references | Monoclonal |
WB
EL
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| Novus Biologicals | AF5430 |
4 references | Polyclonal |
WB
IP
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| LSBio | LS-C662700 |
Polyclonal |
WB
EL
IHC
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| R&D Systems | AF5430 |
3 references | Polyclonal |
WB
IP
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