PABC-140

antibody from Creative Biolabs

Targeting: CFD ADN, DF, PFD

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

PABC-140

Provider

Creative Biolabs

Product name

Human Anti-CFD Recombinant Antibody (clone AFD)

Antibody type

Monoclonal

Description

Recombinant Human Antibody (AFD) is capable of binding to CFD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CFD mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-CFD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. AFD inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis, providing the molecular basis of AFD-mediated inhibition of a rate-limiting step in the alternative complement pathway.

Reactivity

Human

Host

Human

Antibody clone number

AFD

Storage

Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.