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- References [22]
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- Immunohistochemistry [1]
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- Product number
- 10923-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10923-1-AP, RRID:AB_2097096
- Product name
- E2F4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated E2F4 antibody (Cat. #10923-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
METTL14 knockdown mitigates HG-induced HK-2 cell apoptosis, inflammation, and ferroptosis by promoting SLC40A1.
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
SNRPB2 facilitates esophageal squamous cell carcinoma oncogenesis and progression via E2F4 stabilization.
Saxifraga stolonifera inhibits porcine epidemic diarrhea virus infection by disrupting nucleocapsid protein-p53 interaction.
Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2(high) thecal cell proliferation in androgen-induced PCOS mice.
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer.
Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis.
TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis.
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
E2F-mediated POLA2 upregulation is correlated with macrophage infiltration and poor prognosis in hepatocellular carcinoma.
A Positive Feedback Loop of E2F4-Mediated Activation of MNX1 Regulates Tumour Progression in Colorectal Cancer.
Elucidating the pharmacological effects of Compound Kushen injection on MYC-P15-CCND1 signaling pathway in nasopharyngeal carcinoma - An in vitro study.
Activation of Wnt/β‑Catenin‑p130/E2F4 promotes the differentiation of bone marrow‑derived mesenchymal stem cells into type II alveolar epithelial cells through cell cycle arrest.
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression.
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis.
Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase.
Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation.
Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression.
Stable overexpression of p130/E2F4 affects the multipotential abilities of bone-marrow-derived mesenchymal stem cells.
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
METTL14 knockdown mitigates HG-induced HK-2 cell apoptosis, inflammation, and ferroptosis by promoting SLC40A1.
Jin G, Zhao J, Liang Y, Yan X
European journal of medical research 2026 Jan 23;31(1):305
European journal of medical research 2026 Jan 23;31(1):305
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression.
Peng Z, Ma B, Song Z, Zhao Y, Yang Y, Liu Y, Li C, Zhang Y
Oncogene 2026 Apr;45(12):1145-1160
Oncogene 2026 Apr;45(12):1145-1160
SNRPB2 facilitates esophageal squamous cell carcinoma oncogenesis and progression via E2F4 stabilization.
Xu F, Zhu CC, Lu C, Ning GY, Zhang RQ
Frontiers in immunology 2025;16:1610721
Frontiers in immunology 2025;16:1610721
Saxifraga stolonifera inhibits porcine epidemic diarrhea virus infection by disrupting nucleocapsid protein-p53 interaction.
Lu H, Liu H, Guo N, Zhou Y, Lu H, He Z, Dong H
Frontiers in cellular and infection microbiology 2025;15:1615300
Frontiers in cellular and infection microbiology 2025;15:1615300
Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2(high) thecal cell proliferation in androgen-induced PCOS mice.
Luo M, Tian X, Li L, Zhang G, Liu W, Mei L, Li H, You X, Zhang D, Zhou M, Xiao C, Ye J, Yang X
Frontiers in cell and developmental biology 2025;13:1633254
Frontiers in cell and developmental biology 2025;13:1633254
Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer.
Zhang W, Gai Y, Qiao M, Rowicki M, Wei Y, Hang X, Wei Z, Yang H, Ye X, Ju H, Lu Y, Kang Y, Shen M
Signal transduction and targeted therapy 2025 Nov 18;10(1):373
Signal transduction and targeted therapy 2025 Nov 18;10(1):373
Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis.
Li J, Zhao B, Yu Y, Bao Z, Zheng F, Cai J, Chen Y, Wu X
International journal of biological macromolecules 2025 Mar;295:139292
International journal of biological macromolecules 2025 Mar;295:139292
TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis.
Wu JH, Liu YX, Zong JB, Qiu M, Zhou YF, Li YN, Aili T, Zhao XR, Hu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2409250
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2409250
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Xu M, Li F, Xu X, Hu N, Miao J, Zhao Y, Ji S, Wang Y, Wang L
Ecotoxicology and environmental safety 2024 Feb;271:115989
Ecotoxicology and environmental safety 2024 Feb;271:115989
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
E2F-mediated POLA2 upregulation is correlated with macrophage infiltration and poor prognosis in hepatocellular carcinoma.
Teng Y, Liu R
Translational cancer research 2024 Apr 30;13(4):1848-1860
Translational cancer research 2024 Apr 30;13(4):1848-1860
A Positive Feedback Loop of E2F4-Mediated Activation of MNX1 Regulates Tumour Progression in Colorectal Cancer.
Li JK, Liu H, Zhang HW, Li J, Liang ZT
Journal of Cancer 2023;14(14):2739-2750
Journal of Cancer 2023;14(14):2739-2750
Elucidating the pharmacological effects of Compound Kushen injection on MYC-P15-CCND1 signaling pathway in nasopharyngeal carcinoma - An in vitro study.
Wu Z, Wu C, Shi J, Huang Z, Lu S, Tan Y, You R, Hai L, Huang J, Guo S, Gao Y, Jin Z, Tao X, You L, Wu J
Journal of ethnopharmacology 2023 Oct 28;315:116702
Journal of ethnopharmacology 2023 Oct 28;315:116702
Activation of Wnt/β‑Catenin‑p130/E2F4 promotes the differentiation of bone marrow‑derived mesenchymal stem cells into type II alveolar epithelial cells through cell cycle arrest.
Zhang X, Xue M, Liu A, Qiu H, Guo F
Experimental and therapeutic medicine 2023 Jul;26(1):330
Experimental and therapeutic medicine 2023 Jul;26(1):330
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression.
Rousseau V, Einig E, Jin C, Horn J, Riebold M, Poth T, Jarboui MA, Flentje M, Popov N
Nature communications 2023 Aug 23;14(1):5143
Nature communications 2023 Aug 23;14(1):5143
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis.
Wang Y, Liu L, Song Y, Yu X, Deng H
Protein & cell 2022 Oct;13(10):742-759
Protein & cell 2022 Oct;13(10):742-759
Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase.
Wang Y, Lu H, Sun L, Chen X, Wei H, Suo C, Feng J, Yuan M, Shen S, Jia W, Wang Y, Zhang H, Li Z, Zhong X, Gao P
Cell death & disease 2021 Oct 2;12(10):902
Cell death & disease 2021 Oct 2;12(10):902
Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation.
Huang W, Hu H, Zhang Q, Wu X, Wei F, Yang F, Gan L, Wang N, Yang X, Guo AY
Oncogene 2019 Oct;38(42):6818-6834
Oncogene 2019 Oct;38(42):6818-6834
Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression.
Sutton MN, Huang GY, Zhou J, Mao W, Langley R, Lu Z, Bast RC Jr
Cancers 2019 Apr 30;11(5)
Cancers 2019 Apr 30;11(5)
Stable overexpression of p130/E2F4 affects the multipotential abilities of bone-marrow-derived mesenchymal stem cells.
Zhang X, Chen J, Liu A, Xu X, Xue M, Xu J, Yang Y, Qiu H, Guo F
Journal of cellular physiology 2018 Dec;233(12):9739-9749
Journal of cellular physiology 2018 Dec;233(12):9739-9749
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Valle BL, D'Souza T, Becker KG, Wood WH 3rd, Zhang Y, Wersto RP, Morin PJ
PloS one 2013;8(4):e61836
PloS one 2013;8(4):e61836
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 10923-1-AP(E2F4 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The E2F4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human E2F4. This antibody recognizes human, mouse, rat antigen. The E2F4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
