Tissue expression
Cell line expression
Protein structure

E2F4

E2F transcription factor 4
E2F-4 
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
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544 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
antibodies-online
120 antibodies
Novus Biologicals
5 antibodies
Invitrogen Antibodies
31 antibodies
Santa Cruz Biotechnology
1 antibody
Biorbyt
82 antibodies
Affinity Biosciences
1 antibody
FineTest Biotech
1 antibody
NovoPro Bioscience Inc.
1 antibody
St John's Laboratory
11 antibodies
Cusabio Biotech Co., Ltd
10 antibodies
OriGene
14 antibodies
Abnova Corporation
6 antibodies
Aviva Systems Biology
2 antibodies
Acris Antibodies GmbH
7 antibodies
Bethyl Laboratories
3 antibodies
Cell Signaling Technology, Inc
1 antibody
NSJ Bioreagents
9 antibodies
GeneTex
6 antibodies
Boster Biological Technology
3 antibodies
Abbkine Scientific Co.Ltd.
3 antibodies
Antibodies.com
2 antibodies
Everest Biotech
2 antibodies
Abgent
3 antibodies
Bioss
1 antibody
FabGennix
3 antibodies
ProSci
3 antibodies
Creative Diagnostics
5 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
1 antibody
R&D Systems
1 antibody
RabMAbs
1 antibody
Creative Biolabs
16 antibodies
MyBioSource
7 antibodies
GenWay
6 antibodies
EMD Millipore
2 antibodies
United States Biological
46 antibodies
Abbexa
8 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Leading Biology
3 antibodies