Tissue expression
Cell line expression
Protein structure
ALAS1
5'-aminolevulinate synthase 1ALAS, ALAS3
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Top validated antibodies |
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NSJ Bioreagents | RQ5867 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Boster Biological Technology | A10405-1 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Atlas Antibodies | HPA035860 | Polyclonal |
WB
ICC
IHC
|
||
Proteintech Group | 16200-1-AP | 5 references | Polyclonal |
WB
EL
ICC
|
|
Invitrogen Antibodies | 16200-1-AP | Polyclonal |
WB
ICC
IP
OA |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider