Tissue expression
Cell line expression
Protein structure
MED1
Mediator complex subunit 1CRSP1, CRSP200, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | A700-037 | Monoclonal |
WB
ICC
IP
IHC
OA
|
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LSBio | LS-C199486 | Polyclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | NB100-2574 | 1 references | Polyclonal |
WB
IP
IHC
|
|
Biorbyt | orb1187924 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
||
antibodies-online | ABIN2903697 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
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Supportive data in Antibodypedia
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Recommended by provider