24552-1-AP

antibody from Proteintech Group

Targeting: ITGA2B CD41, CD41B, GP2B, PPP1R93

Provider product page for 24552-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 24552-1-AP - Provider product page
Provider: Proteintech Group
Product name: CD41/Integrin Alpha 2B antibody
Antibody type: Polyclonal
Description: CD41/Integrin Alpha 2B antibody (Cat. #24552-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ITGA2B protein structure - 24552-1-AP shown in red.

Submitted references Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.

Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
European journal of pharmacology 2024 May 15;971:176548

Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.

Zhao Z, Wang X, Ma Y, Duan X
International journal of molecular sciences 2024 Jan 4;25(1)

Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.

Li F, Rong Z, Chen T, Wang P, Di X, Ni L, Liu C
International journal of nanomedicine 2023;18:5011-5030

Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages.

Li X, Chen X, Gong S, Zhao J, Yao C, Zhu H, Xiao R, Qin Y, Li R, Sun N, Li X, Dong F, Zhao T, Pan Y, Yang J
Theranostics 2023;13(6):2040-2056

Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.

Liu K, Hao Z, Zheng H, Wang H, Zhang L, Yan M, Tuerhong R, Zhou Y, Wang Y, Pang T, Shi L
Thrombosis research 2023 Sep;229:53-68

SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.

Zhang CL, Shen Q, Liu FD, Yang F, Gao MQ, Jiang XC, Li Y, Zhang XY, En GE, Pan X, Pang B
Scientific reports 2023 Oct 31;13(1):18727

Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing.

Dong H, Li J, Huang X, Liu H, Gui R
International journal of biological macromolecules 2023 Nov 1;251:126393

Bioprotective role of platelet-derived microvesicles in hypothermia: Insight into the differential characteristics of peripheral and splenic platelets.

Horioka K, Tanaka H, Okaba K, Yamada S, Hayakawa A, Ishii N, Motomura A, Inoue H, Takauji S, Isozaki S, Ogawa K, Yajima D, Druid H, Pakanen L, Porvari K
Thrombosis research 2023 Mar;223:155-167

The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases.

Tan R, Yuan M, Wang L, Liu J, Jiang G, Liao J, Xia YL, Yin X, Liu Y
Thrombosis research 2023 Jun;226:69-81

Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis.

Liang Y, Wang J, Xu C, Han W, Wu S, Wu Y, Zhang J, Liu J, Zhang Z, Shi J, Zhang K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300127

Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.

Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512

SINE-VNTR-Alu retrotransposon insertion as a novel mutational event underlying Glanzmann thrombasthenia.

Zhang J, Tang J, Li G, Li N, Wang J, Yao R, Yu T
Journal of thrombosis and haemostasis : JTH 2023 Dec;21(12):3597-3607

The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling.

Zhang T, Mo Q, Jiang N, Wu Y, Yang X, Chen W, Li Q, Yang S, Yang J, Zeng J, Huang F, Huang Q, Luo J, Wu J, Wang L
European journal of pharmacology 2023 Apr 5;944:175604

Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage.

Song N, Pan K, Chen L, Jin K
Frontiers in endocrinology 2022;13:868893

A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.

Chen W, Zhu L, Wang L, Zeng J, Wen M, Xu X, Zou L, Huang F, Huang Q, Qin D, Mei Q, Yang J, Wang Q, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)

Microfluidic-based in vitro thrombosis model for studying microplastics toxicity.

Chen L, Zheng Y, Liu Y, Tian P, Yu L, Bai L, Zhou F, Yang Y, Cheng Y, Wang F, Zheng L, Jiang F, Zhu Y
Lab on a chip 2022 Mar 29;22(7):1344-1353

Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.

Zhou T, Yang X, Wang T, Xu M, Huang Z, Yu R, Jiang Y, Zhou Y, Shi J
Membranes 2022 Jun 10;12(6)

Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model.

Takauji S, Tanaka H, Hayakawa M, Horioka K, Isozaki S, Konishi H
Biochemical and biophysical research communications 2022 Jan 8;587:1-8

Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.

Chen X, Wang C, Sun N, Pan S, Li R, Li X, Zhao J, Tong H, Tang Y, Han J, Qiao J, Qiu H, Wang H, Yang J, Ikezoe T
Theranostics 2021;11(10):4655-4671

Integrin Alpha-2 as a Potential Prognostic and Predictive Biomarker for Patients With Lower-Grade Glioma.

Lin L, Huang K, Tu Z, Zhu X, Li J, Lei K, Luo M, Wang P, Gong C, Long X, Wu L
Frontiers in oncology 2021;11:738651

Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.

Zhao G, Li J, Fangfang Lv, Wang X, Dong Q, Liu D, Zhang J, Li Z, Zhou X, Liu H
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164

DMAG, a novel countermeasure for the treatment of thrombocytopenia.

Lin J, Zeng J, Liu S, Shen X, Jiang N, Wu YS, Li H, Wang L, Wu JM
Molecular medicine (Cambridge, Mass.) 2021 Nov 27;27(1):149

Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

Shan Z, Li L, Atkins CL, Wang M, Wen Y, Jeong J, Moreno NF, Feng D, Gui X, Zhang N, Lee CG, Elias JA, Lee WM, Gao B, Lam FW, An Z, Ju C
eLife 2021 Jun 10;10

Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model.

Wu L, Guo N, Xu Z, Wang W, Xiong Q, Hu J, Wan R, Hong K
BMC pulmonary medicine 2021 Jan 6;21(1):3

MicroRNA-155-5p promotes tumor progression and contributes to paclitaxel resistance via TP53INP1 in human breast cancer.

Li Y, Zhang L, Dong Z, Xu H, Yan L, Wang W, Yang Q, Chen C
Pathology, research and practice 2021 Apr;220:153405

Platelet-derived porous nanomotor for thrombus therapy.

Wan M, Wang Q, Wang R, Wu R, Li T, Fang D, Huang Y, Yu Y, Fang L, Wang X, Zhang Y, Miao Z, Zhao B, Wang F, Mao C, Jiang Q, Xu X, Shi D
Science advances 2020 May;6(22):eaaz9014

Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.

Zhan T, Wei T, Dong L, Wang Q, Wu Z, Yan Q, Zhang W, Lu Y, Wu M
Molecular immunology 2020 Apr;120:83-92

The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine.

Zhang Y, Yu D, Zhang J, Bao J, Tang C, Zhang Z
Metallomics : integrated biometal science 2020 Apr 1;12(4):607-616

Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.

Su C, Wang Q, Zhang H, Jiao W, Luo H, Li L, Chen X, Liu B, Yu X, Li S, Wang W, Guo S
Frontiers in pharmacology 2019;10:990

RhTyrRS (Y341A), a novel human tyrosyl-tRNA synthetase mutant, stimulates thrombopoiesis through activation of the VEGF-R II/NF-κB pathway.

Shi Y, Yu J, Zhang Y, Zhao B, Li Y, Ye Y, Yu Q, Yu M, Mo W, Gu J
Biochemical pharmacology 2019 Nov;169:113634

Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.

Sun Y, Dai H, Chen S, Zhang Y, Wu T, Cao X, Zhao G, Xu A, Wang J, Wu L
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2456-2465

Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors.

Luo Q, Wei G, Wu X, Tang K, Xu M, Wu Y, Liu Y, Li X, Sun Z, Ju W, Qi K, Chen C, Yan Z, Cheng H, Zhu F, Li Z, Zeng L, Xu K, Qiao J
Journal of translational medicine 2018 Nov 15;16(1):311

Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.

Zhu J, Xu M, Gao M, Zhang Z, Xu Y, Xia T, Liu S
ACS nano 2017 Mar 28;11(3):2637-2651

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human blood tissue were subjected to SDS PAGE followed by western blot with 24552-1-AP( ITGA2B Antibody) at dilution of 1:3000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CD41/Integrin alpha 2b antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CD41/Integrin alpha 2b. This antibody recognizes human antigen. The CD41/Integrin alpha 2b antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 24552-1-AP.pdf

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