Antibody data
- Antibody Data
- Antigen structure
- References [64]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 24552-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- CD41/Integrin Alpha 2B antibody
- Antibody type
- Polyclonal
- Description
- CD41/Integrin Alpha 2B antibody (Cat. #24552-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A large puncture closer of aortic wall by multi-memory actions with thrombo-hemodynamic control.
Preparation of Platelet Membrane-Coated Gelatin Nanoparticle Toward Alternative to Platelet Preparation.
Gancao decoction ameliorated senecionine-induced Hepatic Sinusoidal Obstruction Syndrome in mice by inhibiting NET formation and senecionine bioactivation in liver.
Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.
Therapeutic Targeting of the IRF9/RTN4/RHOA/ROCK Pathway via RVG29-Modified PLGA Nanoparticles and rTMS for Neural and Vascular Regeneration Post-Cerebral Infarction.
Silencing Ubiquitin-Specific Peptidase 10 Alleviates Persistent Corneal Epithelial Defect in Mice.
Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy.
Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs.
Integrin β3-mediated platelet extracellular vesicle adhesion facilitates vascular smooth muscle cell dysfunction in postinjury intimal hyperplasia.
A predominant role of platelet NLRP3 in deep vein thrombosis in mice.
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level.
Proteomic insights into platelet dysregulation and pathogenic mechanisms of chronic thromboembolic pulmonary hypertension.
MOF-Engineered Platelet-Mimicking Nanocarrier-Encapsulated Cascade Enzymes for ROS Scavenging and Anti-Inflammation in Cerebral Ischemia-Reperfusion Injury.
Ozone aging amplifies the tumor-promoting effects associated with low-dose graphene oxide exposure in bladder tumors via the integrin αV signaling pathway.
Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement.
Engineered platelets-based nano-aircraft system for precise tumor chemo-immunotherapy with graded drug delivery and self-recognized tumor targeting.
Sex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis.
Platelet membrane-cloaked biomimetic nanoparticles for targeted acute lung injury therapy.
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Anti-Infective Polyurethane Dressings via Ultrafast Laser Micro/Nanostructuring.
Platelet NLRP6 protects against microvascular thrombosis in sepsis.
Platelet-Specific Deletion of TGF-β1 Impairs Septic Thrombosis in Mice-Brief Report.
C1GALT1 high expression enhances the progression of glioblastoma through the EGFR-AKT/ERK cascade.
Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis.
Antibacterial chitosan/organic rectorite nanocomposite-conjugated gelatin/β-cyclodextrin hydrogels with improved hemostasis performance for wound repair.
Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration.
Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis.
Platelets camouflaged nanovehicle improved bladder cancer immunotherapy by triggering pyroptosis.
Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.
Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.
Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages.
Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.
SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.
Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing.
Bioprotective role of platelet-derived microvesicles in hypothermia: Insight into the differential characteristics of peripheral and splenic platelets.
The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases.
Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.
SINE-VNTR-Alu retrotransposon insertion as a novel mutational event underlying Glanzmann thrombasthenia.
TLR4 Agonist MPLA Ameliorates Heavy-Ion Radiation Damage via Regulating DNA Damage Repair and Apoptosis.
The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling.
Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage.
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity.
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model.
Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.
Integrin Alpha-2 as a Potential Prognostic and Predictive Biomarker for Patients With Lower-Grade Glioma.
Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.
DMAG, a novel countermeasure for the treatment of thrombocytopenia.
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.
Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model.
MicroRNA-155-5p promotes tumor progression and contributes to paclitaxel resistance via TP53INP1 in human breast cancer.
Platelet-derived porous nanomotor for thrombus therapy.
Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.
The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine.
Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.
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Integrin β3-mediated platelet extracellular vesicle adhesion facilitates vascular smooth muscle cell dysfunction in postinjury intimal hyperplasia.
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Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis.
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Antibacterial chitosan/organic rectorite nanocomposite-conjugated gelatin/β-cyclodextrin hydrogels with improved hemostasis performance for wound repair.
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Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.
Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
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Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway.
Zhao Z, Wang X, Ma Y, Duan X
International journal of molecular sciences 2024 Jan 4;25(1)
International journal of molecular sciences 2024 Jan 4;25(1)
Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.
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Nature communications 2024 Aug 27;15(1):7396
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Li F, Rong Z, Chen T, Wang P, Di X, Ni L, Liu C
International journal of nanomedicine 2023;18:5011-5030
International journal of nanomedicine 2023;18:5011-5030
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages.
Li X, Chen X, Gong S, Zhao J, Yao C, Zhu H, Xiao R, Qin Y, Li R, Sun N, Li X, Dong F, Zhao T, Pan Y, Yang J
Theranostics 2023;13(6):2040-2056
Theranostics 2023;13(6):2040-2056
Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.
Liu K, Hao Z, Zheng H, Wang H, Zhang L, Yan M, Tuerhong R, Zhou Y, Wang Y, Pang T, Shi L
Thrombosis research 2023 Sep;229:53-68
Thrombosis research 2023 Sep;229:53-68
SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.
Zhang CL, Shen Q, Liu FD, Yang F, Gao MQ, Jiang XC, Li Y, Zhang XY, En GE, Pan X, Pang B
Scientific reports 2023 Oct 31;13(1):18727
Scientific reports 2023 Oct 31;13(1):18727
Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing.
Dong H, Li J, Huang X, Liu H, Gui R
International journal of biological macromolecules 2023 Nov 1;251:126393
International journal of biological macromolecules 2023 Nov 1;251:126393
Bioprotective role of platelet-derived microvesicles in hypothermia: Insight into the differential characteristics of peripheral and splenic platelets.
Horioka K, Tanaka H, Okaba K, Yamada S, Hayakawa A, Ishii N, Motomura A, Inoue H, Takauji S, Isozaki S, Ogawa K, Yajima D, Druid H, Pakanen L, Porvari K
Thrombosis research 2023 Mar;223:155-167
Thrombosis research 2023 Mar;223:155-167
The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases.
Tan R, Yuan M, Wang L, Liu J, Jiang G, Liao J, Xia YL, Yin X, Liu Y
Thrombosis research 2023 Jun;226:69-81
Thrombosis research 2023 Jun;226:69-81
Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis.
Liang Y, Wang J, Xu C, Han W, Wu S, Wu Y, Zhang J, Liu J, Zhang Z, Shi J, Zhang K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300127
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(18):e2300127
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1.
Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X, Huang B
Nature immunology 2023 Dec;24(12):2042-2052
Nature immunology 2023 Dec;24(12):2042-2052
SINE-VNTR-Alu retrotransposon insertion as a novel mutational event underlying Glanzmann thrombasthenia.
Zhang J, Tang J, Li G, Li N, Wang J, Yao R, Yu T
Journal of thrombosis and haemostasis : JTH 2023 Dec;21(12):3597-3607
Journal of thrombosis and haemostasis : JTH 2023 Dec;21(12):3597-3607
TLR4 Agonist MPLA Ameliorates Heavy-Ion Radiation Damage via Regulating DNA Damage Repair and Apoptosis.
Liu T, Wang H, Shen H, Du Z, Wan Z, Li J, Zhang X, Li Z, Yang N, Yang Y, Chen Y, Gao F, Cao K
Radiation research 2023 Aug 1;200(2):127-138
Radiation research 2023 Aug 1;200(2):127-138
The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling.
Zhang T, Mo Q, Jiang N, Wu Y, Yang X, Chen W, Li Q, Yang S, Yang J, Zeng J, Huang F, Huang Q, Luo J, Wu J, Wang L
European journal of pharmacology 2023 Apr 5;944:175604
European journal of pharmacology 2023 Apr 5;944:175604
Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage.
Song N, Pan K, Chen L, Jin K
Frontiers in endocrinology 2022;13:868893
Frontiers in endocrinology 2022;13:868893
A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways.
Chen W, Zhu L, Wang L, Zeng J, Wen M, Xu X, Zou L, Huang F, Huang Q, Qin D, Mei Q, Yang J, Wang Q, Wu J
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity.
Chen L, Zheng Y, Liu Y, Tian P, Yu L, Bai L, Zhou F, Yang Y, Cheng Y, Wang F, Zheng L, Jiang F, Zhu Y
Lab on a chip 2022 Mar 29;22(7):1344-1353
Lab on a chip 2022 Mar 29;22(7):1344-1353
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
Zhou T, Yang X, Wang T, Xu M, Huang Z, Yu R, Jiang Y, Zhou Y, Shi J
Membranes 2022 Jun 10;12(6)
Membranes 2022 Jun 10;12(6)
Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model.
Takauji S, Tanaka H, Hayakawa M, Horioka K, Isozaki S, Konishi H
Biochemical and biophysical research communications 2022 Jan 8;587:1-8
Biochemical and biophysical research communications 2022 Jan 8;587:1-8
Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.
Chen X, Wang C, Sun N, Pan S, Li R, Li X, Zhao J, Tong H, Tang Y, Han J, Qiao J, Qiu H, Wang H, Yang J, Ikezoe T
Theranostics 2021;11(10):4655-4671
Theranostics 2021;11(10):4655-4671
Integrin Alpha-2 as a Potential Prognostic and Predictive Biomarker for Patients With Lower-Grade Glioma.
Lin L, Huang K, Tu Z, Zhu X, Li J, Lei K, Luo M, Wang P, Gong C, Long X, Wu L
Frontiers in oncology 2021;11:738651
Frontiers in oncology 2021;11:738651
Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.
Zhao G, Li J, Fangfang Lv, Wang X, Dong Q, Liu D, Zhang J, Li Z, Zhou X, Liu H
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164
DMAG, a novel countermeasure for the treatment of thrombocytopenia.
Lin J, Zeng J, Liu S, Shen X, Jiang N, Wu YS, Li H, Wang L, Wu JM
Molecular medicine (Cambridge, Mass.) 2021 Nov 27;27(1):149
Molecular medicine (Cambridge, Mass.) 2021 Nov 27;27(1):149
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.
Shan Z, Li L, Atkins CL, Wang M, Wen Y, Jeong J, Moreno NF, Feng D, Gui X, Zhang N, Lee CG, Elias JA, Lee WM, Gao B, Lam FW, An Z, Ju C
eLife 2021 Jun 10;10
eLife 2021 Jun 10;10
Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model.
Wu L, Guo N, Xu Z, Wang W, Xiong Q, Hu J, Wan R, Hong K
BMC pulmonary medicine 2021 Jan 6;21(1):3
BMC pulmonary medicine 2021 Jan 6;21(1):3
MicroRNA-155-5p promotes tumor progression and contributes to paclitaxel resistance via TP53INP1 in human breast cancer.
Li Y, Zhang L, Dong Z, Xu H, Yan L, Wang W, Yang Q, Chen C
Pathology, research and practice 2021 Apr;220:153405
Pathology, research and practice 2021 Apr;220:153405
Platelet-derived porous nanomotor for thrombus therapy.
Wan M, Wang Q, Wang R, Wu R, Li T, Fang D, Huang Y, Yu Y, Fang L, Wang X, Zhang Y, Miao Z, Zhao B, Wang F, Mao C, Jiang Q, Xu X, Shi D
Science advances 2020 May;6(22):eaaz9014
Science advances 2020 May;6(22):eaaz9014
Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice.
Zhan T, Wei T, Dong L, Wang Q, Wu Z, Yan Q, Zhang W, Lu Y, Wu M
Molecular immunology 2020 Apr;120:83-92
Molecular immunology 2020 Apr;120:83-92
The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine.
Zhang Y, Yu D, Zhang J, Bao J, Tang C, Zhang Z
Metallomics : integrated biometal science 2020 Apr 1;12(4):607-616
Metallomics : integrated biometal science 2020 Apr 1;12(4):607-616
Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.
Su C, Wang Q, Zhang H, Jiao W, Luo H, Li L, Chen X, Liu B, Yu X, Li S, Wang W, Guo S
Frontiers in pharmacology 2019;10:990
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- human blood tissue were subjected to SDS PAGE followed by western blot with 24552-1-AP( ITGA2B Antibody) at dilution of 1:3000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The CD41/Integrin alpha 2b antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CD41/Integrin alpha 2b. This antibody recognizes human antigen. The CD41/Integrin alpha 2b antibody has been validated for the following applications: ELISA, WB, IHC analysis.