RA0422

antibody from Oursmab

Targeting: ITGA2B CD41, CD41B, GP2B, PPP1R93

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0422

Provider

Oursmab

Product name

Abciximab (Biosimilar Reference Antibody) (ITGA2B)

Antibody type

Monoclonal

Description

Abciximab (ReoPro) is the Fab fragment of a human-murine chimeric monoclonal antibody originally directed against the human platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor. Abciximab acts as a potent, non-competitive antagonist by binding to the GPIIb/IIIa receptor on the surface of platelets, thereby preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands. This blockade is the final common pathway for platelet aggregation. It is primarily used as an adjunct to percutaneous coronary intervention (PCI) for the prevention of ischemic cardiac complications. Due to its mechanism and relatively long half-life, its clinical use has been associated with a risk of bleeding and thrombocytopenia.

Reactivity

Human

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.