BS3761

antibody from Bioworld Technology, Inc

Targeting: LRP1 A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R1, LRP, LRP1A

Western blot (Data presented on provider website)

Antibody Data

Product number

BS3761

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS3761, RRID:AB_1914264

Product name

LRP1 (G4514) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to the C-terminus of Human LRP1.

Description

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and Ï«-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including Ï«-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer£ªs disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.