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Protein structure
LRP1
LDL receptor related protein 1A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R1, LRP, LRP1A
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-31959 |
2 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| GeneTex | GTX79843 |
2 references | Monoclonal |
WB
ICC
IHC
FC
BN
IEM
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| Novus Biologicals | NB100-64808 |
1 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| Boster Biological Technology | M00829 |
3 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Antibodies.com | A279602 |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
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