AGTO-L081E

antibody from Creative Biolabs

Targeting: LRP1 A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R1, LRP, LRP1A

No application information provided.

Antibody Data

Product number

AGTO-L081E

Provider

Creative Biolabs

Product name

RAP-PE immunotoxin

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the RAP to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Glioma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Glioma.

Reactivity

Human

Host

Human