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- Antibody Data
- Antigen structure
- References [80]
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- Western blot [1]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- 13241-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CYP1A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYP1A1 antibody (Cat. #13241-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt.
TolDC Restores the Balance of Th17/Treg via Aryl Hydrocarbon Receptor to Attenuate Colitis.
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota.
StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation.
Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways.
Mulberry leaf supplementation inhibits skatole deposition by regulating gut microbiota and upregulating liver cytochrome P450 1A1 expression in finishing pigs.
Benvitimod Inhibits IL-4- and IL-13-Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes.
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Quercetin ameliorates ulcerative colitis by activating aryl hydrocarbon receptor to improve intestinal barrier integrity.
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration.
Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression.
HDAC inhibitors support long-term expansion of porcine hepatocytes in vitro.
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo.
Sex Differences in Genomic Features of Hepatitis B-Associated Hepatocellular Carcinoma With Distinct Antitumor Immunity.
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.
Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.
Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.
Activated intestinal microbiome-associated tryptophan metabolism upregulates aryl hydrocarbon receptor to promote osteoarthritis in a rat model.
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.
Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells.
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice.
Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling.
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Tumor stromal topography promotes chemoresistance in migrating breast cancer cell clusters.
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
Hypoxia-responsive covalent organic framework by single NIR laser-triggered for multimodal synergistic therapy of triple-negative breast cancer.
Glutamine alleviates intestinal injury in a murine burn sepsis model by maintaining intestinal intraepithelial lymphocyte homeostasis.
Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice.
5-Methoxyflavone ameliorates non-alcoholic fatty liver disease through targeting the cytochrome P450 1A1.
Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40).
QingXiaoWuWei decoction alleviates methicillin-resistant Staphylococcus aureus-induced pneumonia in mice by regulating metabolic remodeling and macrophage gene expression network via the microbiota-short-chain fatty acids axis.
Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.
Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Hepar-on-a-sensor-platform with hybridization chain reaction amplification strategy to intuitively monitor the hepatoxicity of natural compounds.
Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.
Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents.
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Novel fluorescent and secreted transcriptional reporters for quantifying activity of the xenobiotic sensor aryl hydrocarbon receptor (AHR).
Regioselective hydroxylation of carbendazim by mammalian cytochrome P450: A combined experimental and computational study.
Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice.
Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma.
Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor.
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.
Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model.
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma.
Chrysophanol protects human bronchial epithelial cells from cigarette smoke extract (CSE)-induced apoptosis.
Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).
MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease.
Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover.
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line.
In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease.
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells.
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.
Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Ichisaka Y, Yano S, Nishimura K, Niwa T, Shimizu H
Biomedical research (Tokyo, Japan) 2024;45(2):57-66
Biomedical research (Tokyo, Japan) 2024;45(2):57-66
TolDC Restores the Balance of Th17/Treg via Aryl Hydrocarbon Receptor to Attenuate Colitis.
Wang S, Xu Y, Wang L, Lin J, Xu C, Zhao X, Zhang H
Inflammatory bowel diseases 2024 Sep 3;30(9):1546-1555
Inflammatory bowel diseases 2024 Sep 3;30(9):1546-1555
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
Cui J, Chen W, Zhang D, Lu M, Huang Z, Yi B
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota.
Zhang Y, Han L, Dong J, Yuan Z, Yao W, Ji P, Hua Y, Wei Y
Journal of ethnopharmacology 2024 May 23;326:117874
Journal of ethnopharmacology 2024 May 23;326:117874
StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.
Zhou S, Li J, Ying T, Wang Y, Wang Q, Li X, Zhao F
iScience 2024 May 17;27(5):109682
iScience 2024 May 17;27(5):109682
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation.
Liu Y, Bai X, Wu H, Duan Z, Zhu C, Fu R, Fan D
Journal of agricultural and food chemistry 2024 May 1;72(17):9867-9879
Journal of agricultural and food chemistry 2024 May 1;72(17):9867-9879
Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways.
Li X, Jiang X, Zeng R, Lai X, Wang J, Liu H, Wu H, He J, Liu L, Zhu Z, Li J, Liang X
Phytotherapy research : PTR 2024 Mar;38(3):1278-1293
Phytotherapy research : PTR 2024 Mar;38(3):1278-1293
Mulberry leaf supplementation inhibits skatole deposition by regulating gut microbiota and upregulating liver cytochrome P450 1A1 expression in finishing pigs.
Sun Y, Men X, Lin T, Deng B, Zhong S, Huo J, Qin K, Lv Z, Xu Z, Li Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:34-44
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:34-44
Benvitimod Inhibits IL-4- and IL-13-Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes.
Wang X, Mao D, Jia J, Zhang J
The Journal of investigative dermatology 2024 Mar;144(3):509-519.e7
The Journal of investigative dermatology 2024 Mar;144(3):509-519.e7
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Sun D, Bian G, Zhang K, Liu N, Yin Y, Hou Y, Xie F, Zhu W, Mao S, Liu J
Genome biology 2024 Mar 4;25(1):64
Genome biology 2024 Mar 4;25(1):64
Quercetin ameliorates ulcerative colitis by activating aryl hydrocarbon receptor to improve intestinal barrier integrity.
Wang X, Xie X, Li Y, Xie X, Huang S, Pan S, Zou Y, Pan Z, Wang Q, Chen J, Zhou L, Luo X
Phytotherapy research : PTR 2024 Jan;38(1):253-264
Phytotherapy research : PTR 2024 Jan;38(1):253-264
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration.
Hu J, Melchor GS, Ladakis D, Reger J, Kim HW, Chamberlain KA, Shults NV, Oft HC, Smith VN, Rosko LM, Li E, Baydyuk M, Fu MM, Bhargava P, Huang JK
NPJ Regenerative medicine 2024 Jan 2;9(1):1
NPJ Regenerative medicine 2024 Jan 2;9(1):1
Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression.
Fan L, Wang H, Ben S, Cheng Y, Chen S, Ding Z, Zhao L, Li S, Wang M, Cheng G
Journal of biomedical research 2024 Feb 27;38(2):149-162
Journal of biomedical research 2024 Feb 27;38(2):149-162
HDAC inhibitors support long-term expansion of porcine hepatocytes in vitro.
Li G, Zeng M, Yan Z, Cai S, Ma Y, Wang Y, Li S, Li Y, Zhong K, Xiao M, Fu G, Weng J, Gao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116973
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo.
Abduh MS, Alwassil OI, Aldaqal SM, Alfwuaires MA, Farhan M, Hanieh H
Biochemical pharmacology 2024 Apr;222:116079
Biochemical pharmacology 2024 Apr;222:116079
Sex Differences in Genomic Features of Hepatitis B-Associated Hepatocellular Carcinoma With Distinct Antitumor Immunity.
Xu C, Cheng S, Chen K, Song Q, Liu C, Fan C, Zhang R, Zhu Q, Wu Z, Wang Y, Fan J, Zheng H, Lu L, Chen T, Zhao H, Jiao Y, Qu C
Cellular and molecular gastroenterology and hepatology 2023;15(2):327-354
Cellular and molecular gastroenterology and hepatology 2023;15(2):327-354
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T
Journal of gastroenterology 2023 Sep;58(9):868-882
Journal of gastroenterology 2023 Sep;58(9):868-882
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.
Li S, Li L, Zhang C, Fu H, Yu S, Zhou M, Guo J, Fang Z, Li A, Zhao M, Zhang M, Wang X
eLife 2023 Sep 22;12
eLife 2023 Sep 22;12
Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.
Ni Z, Ma H, Li X, Zou L, Liu Z, Wang X, Ma H, Yang L
Environmental toxicology 2023 Nov;38(11):2717-2729
Environmental toxicology 2023 Nov;38(11):2717-2729
Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.
Run L, Tian Z, Xu L, Du J, Li N, Wang Q, Sun H
Applied biochemistry and biotechnology 2023 Nov;195(11):6694-6707
Applied biochemistry and biotechnology 2023 Nov;195(11):6694-6707
Activated intestinal microbiome-associated tryptophan metabolism upregulates aryl hydrocarbon receptor to promote osteoarthritis in a rat model.
Chen L, Huang Z, Li Q, Chen C, Luo Y, Kang P
International immunopharmacology 2023 May;118:110020
International immunopharmacology 2023 May;118:110020
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.
Hu J, Chen J, Xu X, Hou Q, Ren J, Yan X
Microbiome 2023 May 8;11(1):102
Microbiome 2023 May 8;11(1):102
Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells.
Kurata K, Ishii K, Koto Y, Naito K, Yuasa K, Shimizu H
Bioscience, biotechnology, and biochemistry 2023 May 19;87(6):611-619
Bioscience, biotechnology, and biochemistry 2023 May 19;87(6):611-619
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice.
Dona MSI, Hsu I, Meuth AI, Brown SM, Bailey CA, Aragonez CG, Russell JJ, Krstevski C, Aroor AR, Chandrasekar B, Martinez-Lemus LA, DeMarco VG, Grisanti LA, Jaffe IZ, Pinto AR, Bender SB
Basic research in cardiology 2023 Mar 29;118(1):11
Basic research in cardiology 2023 Mar 29;118(1):11
Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling.
Deval G, Nedder M, Degrelle S, Rogozarski J, Vignaud ML, Chissey A, Colzin S, Laguillier-Morizot C, Coumoul X, Boland S, Fournier T, Zerrad-Saadi A, Ferecatu I
International journal of molecular sciences 2023 Mar 12;24(6)
International journal of molecular sciences 2023 Mar 12;24(6)
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Yan B, Mao X, Hu S, Wang S, Liu X, Sun J
International immunopharmacology 2023 Jun;119:110166
International immunopharmacology 2023 Jun;119:110166
Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Dong F, Murray IA, Annalora A, Coslo DM, Desai D, Gowda K, Yang J, Wang D, Koo I, Hao F, Amin SG, Patterson AD, Marcus C, Perdew GH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jul;37(7):e23010
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jul;37(7):e23010
Tumor stromal topography promotes chemoresistance in migrating breast cancer cell clusters.
Su CY, Wu A, Dong Z, Miller CP, Suarez A, Ewald AJ, Ahn EH, Kim DH
Biomaterials 2023 Jul;298:122128
Biomaterials 2023 Jul;298:122128
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
Chen M, Shu Y, Li Q, Kang Z, Liu T, Zhou H, Huang W, Zhang W
NPJ biofilms and microbiomes 2023 Jul 24;9(1):51
NPJ biofilms and microbiomes 2023 Jul 24;9(1):51
Hypoxia-responsive covalent organic framework by single NIR laser-triggered for multimodal synergistic therapy of triple-negative breast cancer.
Han Z, Qian Y, Gao X, Yang D, Cai Y, Chen Y, Jin J, Yang Z
Colloids and surfaces. B, Biointerfaces 2023 Feb;222:113094
Colloids and surfaces. B, Biointerfaces 2023 Feb;222:113094
Glutamine alleviates intestinal injury in a murine burn sepsis model by maintaining intestinal intraepithelial lymphocyte homeostasis.
Chen X, Zhu Y, Wei Y, Fan S, Xia L, Chen Q, Lu Y, Wu D, Liu X, Peng X
European journal of pharmacology 2023 Feb 5;940:175480
European journal of pharmacology 2023 Feb 5;940:175480
Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice.
Wang X, Huang S, Zhang M, Su Y, Pan Z, Liang J, Xie X, Wang Q, Chen J, Zhou L, Luo X
Journal of ethnopharmacology 2023 Feb 10;302(Pt B):115919
Journal of ethnopharmacology 2023 Feb 10;302(Pt B):115919
5-Methoxyflavone ameliorates non-alcoholic fatty liver disease through targeting the cytochrome P450 1A1.
Zhang Y, Fu Q, Wu T, Liu K, Xiao Y, Liao Q, Qi X, Li Y, Zhou L
Free radical biology & medicine 2023 Feb 1;195:178-191
Free radical biology & medicine 2023 Feb 1;195:178-191
Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40).
Li J, Liu B, Wu H, Zhang S, Liang Z, Guo S, Jiang H, Song Y, Lei X, Gao Y, Cheng P, Li D, Wang J, Liu Y, Wang D, Zhan N, Xu J, Wang L, Xiao G, Yang L, Pei G
Bone research 2023 Dec 14;11(1):64
Bone research 2023 Dec 14;11(1):64
QingXiaoWuWei decoction alleviates methicillin-resistant Staphylococcus aureus-induced pneumonia in mice by regulating metabolic remodeling and macrophage gene expression network via the microbiota-short-chain fatty acids axis.
Li J, Zhang Q, Li X, Liu J, Wang F, Zhang W, Liu X, Li T, Wang S, Wang Y, Zhang X, Meng Y, Ma Y, Wang H
Microbiology spectrum 2023 Dec 12;11(6):e0034423
Microbiology spectrum 2023 Dec 12;11(6):e0034423
Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells.
Lin YC, Cheung G, Zhang Z, Papadopoulos V
The Journal of biological chemistry 2023 Aug;299(8):105035
The Journal of biological chemistry 2023 Aug;299(8):105035
Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites.
Patel D, Murray IA, Dong F, Annalora AJ, Gowda K, Coslo DM, Krzeminski J, Koo I, Hao F, Amin SG, Marcus CB, Patterson AD, Perdew GH
Metabolites 2023 Aug 31;13(9)
Metabolites 2023 Aug 31;13(9)
Complex chemical signals dictate Ah receptor activation through the gut-lung axis.
Dong F, Murray IA, Annalora A, Coslo D, Desai D, Gowda K, Yang J, Wang D, Koo I, Hao F, Amin SG, Patterson AD, Marcus C, Perdew GH
bioRxiv : the preprint server for biology 2023 Apr 5;
bioRxiv : the preprint server for biology 2023 Apr 5;
Hepar-on-a-sensor-platform with hybridization chain reaction amplification strategy to intuitively monitor the hepatoxicity of natural compounds.
Qian W, Gong G, Su H, Zhao Y, Fu W, Wang Y, Ji W, Sun X, Zhang B, Ma L, Li J, Zhang X, Li S, Sheng E, Lu Y, Zhu D
Acta biomaterialia 2023 Apr 1;160:73-86
Acta biomaterialia 2023 Apr 1;160:73-86
Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.
Wang Z, Yin L, Qi Y, Zhang J, Zhu H, Tang J
Frontiers in microbiology 2022;13:934786
Frontiers in microbiology 2022;13:934786
Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents.
Song M, Sheng X, Zhang J, Li X, Dai Q, Chen Y, Kang A
Journal of ethnopharmacology 2022 Oct 28;297:115545
Journal of ethnopharmacology 2022 Oct 28;297:115545
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365
BMC medicine 2022 Oct 19;20(1):365
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG
Nature communications 2022 Oct 14;13(1):6080
Nature communications 2022 Oct 14;13(1):6080
Novel fluorescent and secreted transcriptional reporters for quantifying activity of the xenobiotic sensor aryl hydrocarbon receptor (AHR).
Degrelle SA, Ferecatu I, Fournier T
Environment international 2022 Nov;169:107545
Environment international 2022 Nov;169:107545
Regioselective hydroxylation of carbendazim by mammalian cytochrome P450: A combined experimental and computational study.
Lv X, Li JX, Wang JY, Tian XG, Feng L, Sun CP, Ning J, Wang C, Zhao WY, Li YC, Ma XC
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118523
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118523
Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice.
Liu L, Xu J, Xu X, Mao T, Niu W, Wu X, Lu L, Zhou H
International journal of molecular sciences 2022 Dec 8;23(24)
International journal of molecular sciences 2022 Dec 8;23(24)
Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma.
Sun Y, Miao X, Zhu L, Liu J, Lin Y, Xiang G, Wu X, Wang X, Ni Z, Li S
Ecotoxicology and environmental safety 2022 Aug;241:113833
Ecotoxicology and environmental safety 2022 Aug;241:113833
Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor.
Li H, Gao YH, Song L, Chen TF, Zhang GP, Ye ZG, Gao Y, Huo W
Journal of ethnopharmacology 2022 Aug 10;294:115394
Journal of ethnopharmacology 2022 Aug 10;294:115394
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cui X, Ye Z, Wang D, Yang Y, Jiao C, Ma J, Tang N, Zhang H
Cell & bioscience 2022 Apr 23;12(1):46
Cell & bioscience 2022 Apr 23;12(1):46
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Shi F, Zhang Z, Wang J, Wang Y, Deng J, Zeng Y, Zou P, Ling X, Han F, Liu J, Ao L, Cao J
Frontiers in endocrinology 2021;12:807374
Frontiers in endocrinology 2021;12:807374
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.
Chu Y, Zhu Y, Zhang Y, Liu X, Guo Y, Chang L, Yun X, Wei Z, Xia Y, Dai Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21502
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21502
Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model.
Yan L, Messner CJ, Zhang X, Suter-Dick L
Environmental research 2021 Mar;194:110679
Environmental research 2021 Mar;194:110679
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Li H, Wang YG, Ma ZC, Yun-Hang G, Ling S, Teng-Fei C, Guang-Ping Z, Gao Y
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma.
Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X, Zeng Y, Jiao Y
Signal transduction and targeted therapy 2021 Aug 9;6(1):299
Signal transduction and targeted therapy 2021 Aug 9;6(1):299
Chrysophanol protects human bronchial epithelial cells from cigarette smoke extract (CSE)-induced apoptosis.
Wu G, Yuan T, Zhu H, Zhang H, Su J, Guo L, Zhou Q, Xiong F, Yu Q, Yang P, Zhang S, Mo B, Zhao J, Cai J, Wang CY
International journal of molecular epidemiology and genetics 2020;11(3):39-45
International journal of molecular epidemiology and genetics 2020;11(3):39-45
Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).
Zhang N, Wang J, Sheng A, Huang S, Tang Y, Ma S, Hong G
Frontiers in pharmacology 2020;11:622046
Frontiers in pharmacology 2020;11:622046
MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease.
Zhao X, Li J, Ma J, Jiao C, Qiu X, Cui X, Wang D, Zhang H
Inflammation 2020 Oct;43(5):1862-1875
Inflammation 2020 Oct;43(5):1862-1875
Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover.
Zhou H, Zhang L, Li Y, Wu G, Zhu H, Zhang H, Su JK, Guo L, Zhou Q, Xiong F, Yu Q, Yang P, Zhang S, Cai J, Wang CY
BMC pulmonary medicine 2020 Oct 23;20(1):276
BMC pulmonary medicine 2020 Oct 23;20(1):276
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
Tian LX, Tang X, Ma W, Wang J, Zhang W, Liu K, Chen T, Zhu JY, Liang HP
FEBS open bio 2020 Nov;10(11):2316-2328
FEBS open bio 2020 Nov;10(11):2316-2328
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Tao Y, Liu X, Cui L, Liu X, Chen Y, He Z, Ji M, Gao Z, Li N, Wan Z, Yu Z
Toxicology 2020 May 30;438:152444
Toxicology 2020 May 30;438:152444
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Akintade DD, Chaudhuri B
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line.
Ranjit S, Kodidela S, Sinha N, Chauhan S, Kumar S
Viruses 2020 Feb 21;12(2)
Viruses 2020 Feb 21;12(2)
In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease.
Zhu XY, Xia HG, Wang ZH, Li B, Jiang HY, Li DL, Jin R, Jin Y
Toxicology letters 2020 Feb 1;319:85-94
Toxicology letters 2020 Feb 1;319:85-94
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Wang X, Li S, Liu L, Jian Z, Cui T, Yang Y, Guo S, Yi X, Wang G, Li C, Gao T, Li K
Journal of dermatological science 2019 Oct;96(1):33-41
Journal of dermatological science 2019 Oct;96(1):33-41
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Xia H, Zhu X, Zhang X, Jiang H, Li B, Wang Z, Li D, Jin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells.
Xu H, Zhang X, Ye Y, Li X
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104615
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104615
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Sonawane VR, Siddique MUM, Gatchie L, Williams IS, Bharate SB, Jayaprakash V, Sinha BN, Chaudhuri B
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.
Yu M, Wang Q, Ma Y, Li L, Yu K, Zhang Z, Chen G, Li X, Xiao W, Xu P, Yang H
International journal of biological sciences 2018;14(1):69-77
International journal of biological sciences 2018;14(1):69-77
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Huang B, Bao J, Cao YR, Gao HF, Jin Y
Biochemistry. Biokhimiia 2018 May;83(5):595-602
Biochemistry. Biokhimiia 2018 May;83(5):595-602
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Ma Y, Wang Q, Yu K, Fan X, Xiao W, Cai Y, Xu P, Yu M, Yang H
Chemico-biological interactions 2018 May 25;288:83-90
Chemico-biological interactions 2018 May 25;288:83-90
Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.
Liu Z, Li L, Chen W, Wang Q, Xiao W, Ma Y, Sheng B, Li X, Sun L, Yu M, Yang H
International journal of molecular medicine 2018 Mar;41(3):1560-1572
International journal of molecular medicine 2018 Mar;41(3):1560-1572
Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
Wang Q, Yang K, Han B, Sheng B, Yin J, Pu A, Li L, Sun L, Yu M, Qiu Y, Xiao W, Yang H
International journal of molecular medicine 2018 Feb;41(2):868-876
International journal of molecular medicine 2018 Feb;41(2):868-876
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Sharma R, Williams IS, Gatchie L, Sonawane VR, Chaudhuri B, Bharate SB
Bioorganic & medicinal chemistry 2018 Dec 15;26(23-24):6076-6086
Bioorganic & medicinal chemistry 2018 Dec 15;26(23-24):6076-6086
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Sharma R, Williams IS, Gatchie L, Sonawane VR, Chaudhuri B, Bharate SB
ACS omega 2018 Aug 31;3(8):8553-8566
ACS omega 2018 Aug 31;3(8):8553-8566
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.
Lee SR, Lee SY, Kim SY, Ryu SY, Park BK, Hong EJ
Journal of biomedical research 2017 Sep 26;31(5):437-444
Journal of biomedical research 2017 Sep 26;31(5):437-444
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC, Lei T
International journal of molecular medicine 2017 Oct;40(4):1029-1036
International journal of molecular medicine 2017 Oct;40(4):1029-1036
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
Yin J, Sheng B, Han B, Pu A, Yang K, Li P, Wang Q, Xiao W, Yang H
Cell biology international 2016 May;40(5):560-8
Cell biology international 2016 May;40(5):560-8
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Yin J, Sheng B, Pu A, Han B, Yang K, Wang Q, Sun L, Yang H
Digestive diseases and sciences 2016 Feb;61(2):444-52
Digestive diseases and sciences 2016 Feb;61(2):444-52
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Zhang B, Liu Y, Li X
Toxins 2015 Mar 30;7(4):1102-15
Toxins 2015 Mar 30;7(4):1102-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 13241-1-AP(CYP1A1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 13241-1-AP(CYP1A1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP1A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP1A1. This antibody recognizes human, mouse antigen. The CYP1A1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
