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- References [114]
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- Product number
- 12216-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12216-1-AP, RRID:AB_2086929
- Product name
- Cathepsin B antibody
- Antibody type
- Polyclonal
- Description
- Cathepsin B antibody (Cat. #12216-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas.
PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.
Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling.
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury.
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation.
Mechanistic insights into diclofenac-induced acute kidney injury and its antagonists identification.
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors.
Staphylococcus aureus escapes endosomes and autophagosomes via α-hemolysin.
Fragment of esophageal cancer-related gene-4 induces lysosome-dependent cell death via cathepsin secretion in astrocytes.
Occurrence of neuronal dysfunction in mice with virus- or toxic-induced lesions in the central nervous system.
Dual-Shell Chitosan/Ferritin Nanocages Enhance the Stability, Intestinal Transport, and Antiviral Activity of EGCG against HBV.
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
Phosphatidylcholine-derived carriers facilitate brain tumor delivery and enhance glioblastoma therapy.
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells.
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation.
NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury.
Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury.
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
Inhibition of Salt-Inducible Kinase 2 Protects Motor Neurons From Degeneration in ALS by Activating Autophagic Flux and Enhancing mTORC1 Activity.
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α.
The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment.
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy.
Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors.
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.
Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction.
Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging.
Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4.
Exposure to Manganese Induces Autophagy-Lysosomal Pathway Dysfunction-Mediated Tauopathy by Activating the cGAS-STING Pathway in the Brain.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
Cathepsin B promotes optic nerve axonal regeneration.
Alumina nanoparticles induce learning and memory impairment in a particle size-dependent and time-dependent manner.
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Identification and validation of three diagnostic autophagy-related genes associated with advanced plaques and immune cell infiltration in carotid atherosclerosis based on integrated bioinformatics analyses.
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
Acteoside delays the fibrosis process of diabetic nephropathy by anti-oxidation and regulating the autophagy-lysosome pathway.
An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Staphylococcus aureus promotes its intracellular survival by inhibiting Rab11-Rab11FIP4-mediated vesicle trafficking.
MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice.
scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network.
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase.
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.
Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin.
Discovery of sp(3)-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors.
Mitochondria-specific antioxidant MitoTEMPO alleviates senescence of bone marrow mesenchymal stem cells in ovariectomized rats.
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin‑mediated NLRP3 inflammasome activation.
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B.
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage.
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.
The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats.
The cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells.
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics.
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B.
Blockade of Autophagy Prevents the Progression of Hyperuricemic Nephropathy Through Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.
Polystyrene micro(nano)plastics damage the organelles of RBL-2H3 cells and promote MOAP-1 to induce apoptosis.
In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways.
Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor.
Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells.
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy.
Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice.
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells.
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy.
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.
A proteomic approach towards understanding the pathogenesis of Mooren's ulcer.
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop.
Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat.
Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus.
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB.
Promotion of autophagosome-lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease.
Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration.
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells.
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.
Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.
Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection.
Zhang Z, Zhai M, Bao S, Sun X, Chen R, Wang B, Yang F, Yang L, Zhou M
Journal of advanced research 2026 Mar;81:797-808
Journal of advanced research 2026 Mar;81:797-808
PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.
Shen D, Li R, She Y, Liu X, Huang Y, Ji Y, Chen K, Song Z, Chen R, Li X, Zhao Q, Chen Q, Chen M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e15207
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e15207
Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling.
Yin N, Takahashi T, Hayashi H, Sugimoto T, Jeon H, Liu W, Guo Y, Wang Z, Wang C, Hara A, Takami Y, Sakurai T, Nakagami H, Yamamoto K
GeroScience 2026 Mar 9;
GeroScience 2026 Mar 9;
NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.
Zhou S, Li N, Li R, Ding Y, Zhu Y, Pan Y, Liu Y, Zhang Y, Yang H, Wang Q
iScience 2026 Mar 20;29(3):115017
iScience 2026 Mar 20;29(3):115017
CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury.
He S, Wang L, Wang Z, Yu S, Zhu Q, Xu Y, Jiang Y, Wu Y, Xiang H
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Cheng G, Qi C, Xu H, Wang X, Li M, Chen H, Zheng P, Liu Y, Liu J, Zhao X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
Lane AR, Gonzalez N, Gokhale A, Zlatic SA, Allen BM, Scher NE, Roberts AM, Duong DM, Roberts BR, Vrailas-Mortimer AD, Werner E, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 14;
bioRxiv : the preprint server for biology 2026 Jan 14;
A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation.
Wang S, Han W, Zhao B, Hong Y, Li J, Miao J, Lin Z
PLoS pathogens 2026 Feb;22(2):e1013932
PLoS pathogens 2026 Feb;22(2):e1013932
Mechanistic insights into diclofenac-induced acute kidney injury and its antagonists identification.
Zhao F, Zhou X, Chen J, Li R, Sun Y, Zhou J, Li H, Zheng G, Zhu L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Feb;208:115889
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Feb;208:115889
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors.
Xie X, Liu J, Liang W, Zhang Y, Gong X, Yuan S, Qi C, Huang M, Shi L, Hou M, Zhang M, Liu W, Sun W, Wu Y, Li C, Cao Z, Jing H, Qian L, Liu J, Yuan S, Wang Q, Shen Y, Liu Z, Li Y, Pan H, Zhu B, Shan B, He K, Wang W, Zou C, Li Y, Chou JJ, Yuan J
Immunity 2026 Feb 10;59(2):419-437.e11
Immunity 2026 Feb 10;59(2):419-437.e11
Staphylococcus aureus escapes endosomes and autophagosomes via α-hemolysin.
Xu H, Qi C, Qu C, Lou J, Wang X, Zhang H, Liu J, Liu Y
International immunopharmacology 2026 Feb 1;170:116072
International immunopharmacology 2026 Feb 1;170:116072
Fragment of esophageal cancer-related gene-4 induces lysosome-dependent cell death via cathepsin secretion in astrocytes.
Oikawa N, Zhang L, Kondo T
Tissue & cell 2026 Apr 23;102:103553
Tissue & cell 2026 Apr 23;102:103553
Occurrence of neuronal dysfunction in mice with virus- or toxic-induced lesions in the central nervous system.
Dembowski M, Burigk L, Baumgärtner W, Hansmann F
Molecular and cellular neurosciences 2026 Apr 22;:104096
Molecular and cellular neurosciences 2026 Apr 22;:104096
Dual-Shell Chitosan/Ferritin Nanocages Enhance the Stability, Intestinal Transport, and Antiviral Activity of EGCG against HBV.
Dong Y, Yin X, Shan X, Hu Y, Zhu C
Journal of agricultural and food chemistry 2026 Apr 15;74(14):11579-11591
Journal of agricultural and food chemistry 2026 Apr 15;74(14):11579-11591
LAMP2-FLOT2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2.
Shao R, Liu W, Feng Y, Guo X, Ren Z, Hou X, He B
Autophagy 2025 Sep;21(9):1888-1910
Autophagy 2025 Sep;21(9):1888-1910
Phosphatidylcholine-derived carriers facilitate brain tumor delivery and enhance glioblastoma therapy.
Yu J, Tu Z, Fan J, Lei K, Meng Z, Chen B, Wang Z, Escobar W, Zhou J
Journal of controlled release : official journal of the Controlled Release Society 2025 Sep 10;385:113999
Journal of controlled release : official journal of the Controlled Release Society 2025 Sep 10;385:113999
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
Zou W, Fang X, Qian Z, Nie L
Molecular and cellular endocrinology 2025 Sep 1;606:112586
Molecular and cellular endocrinology 2025 Sep 1;606:112586
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Yang R, Zhan Y, Deng Z, Zhang J, Chen S, Zhang Y, Fu H, Meng X, Wu J, Gu Y, Huang Q, Wang C, Xie J
Redox biology 2025 Oct;86:103793
Redox biology 2025 Oct;86:103793
The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells.
Song P, Zhang L, Qiu H, Zhou X, Cao Y, Liu J, Zheng X, Liu Y, Yao S
Genes & genomics 2025 Oct;47(10):1065-1078
Genes & genomics 2025 Oct;47(10):1065-1078
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation.
Xu S, Liu P, Jia J, Sun M, Ma F, Mao R, Li H, Ji S, Bao X, Xia S, Xu Y, Cao X
Journal of neuroinflammation 2025 Oct 31;22(1):253
Journal of neuroinflammation 2025 Oct 31;22(1):253
NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury.
Peng J, Huang Y, He T, Zhan Y, Liu J
Cell death and differentiation 2025 Nov;32(11):2160-2174
Cell death and differentiation 2025 Nov;32(11):2160-2174
Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury.
Yao Z, Lu L, Yu M, Wang H, Shi Y, Ying J, Yu X, Xu Q, Zhang Z, Zhang S, Li Y, Wu Y, Zhu H, Jiang H
Cell communication and signaling : CCS 2025 Nov 28;24(1):97
Cell communication and signaling : CCS 2025 Nov 28;24(1):97
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
Chen Y, Shu C, Yan Z, Zhang S, Zhang W, Zhao J, Wang A, Li J, Zeng Y, Zhu J, Huang JA, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
Modified weiling decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation.
Gao W, Wang M, Xu W, Ma R, Wang X, Sun T, Li P, Li F, He Y, Xie X, Pang X, Zhou Y, Pang G
Journal of ethnopharmacology 2025 May 12;347:119753
Journal of ethnopharmacology 2025 May 12;347:119753
Inhibition of Salt-Inducible Kinase 2 Protects Motor Neurons From Degeneration in ALS by Activating Autophagic Flux and Enhancing mTORC1 Activity.
Liang W, Zhang C, Wang D, Su X, Tan X, Yang Y, Cong C, Wang Y, Huo D, Wang H, Wang S, Wang X, Feng H
CNS neuroscience & therapeutics 2025 Mar;31(3):e70341
CNS neuroscience & therapeutics 2025 Mar;31(3):e70341
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α.
Li Q, Zeng K, Chen Q, Han C, Wang X, Li B, Miao J, Zheng B, Liu J, Yuan X, Liu B
Autophagy 2025 Mar;21(3):619-638
Autophagy 2025 Mar;21(3):619-638
The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment.
Cheng Y, Du Y, Hu Y, Wang X, Li Q, Yan X, Dou M, Jia W, Yu F, Ba Y, Zhou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115267
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115267
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Jing Y, Shi J, Xie Z, Shen Z, Zhang J, Wang F, Li K, Su J, Liu JX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy.
Si M, Fu J, Fang M, Lu Y, Huang J, Li H, Wang P, Liao M, Zhu J, Li P, Zhong W, Guo Z, Yang W, Ye Z, Hu H, Yu X
Nature communications 2025 Jul 1;16(1):5536
Nature communications 2025 Jul 1;16(1):5536
Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors.
Miura K, Umedera K, Doi T, Nakamura H
Bioorganic & medicinal chemistry 2025 Jul 1;124:118200
Bioorganic & medicinal chemistry 2025 Jul 1;124:118200
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.
He Z, Zheng D, Li F, Chen L, Wu C, Zeng Z, Yu C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jan;78:101171
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jan;78:101171
Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction.
Wu H, Cai R, Zhou C, Yang Y, Tian X, Zhao Z, Bai Q, Qiu X, Song Q, Zhang L, Bao H, Liu T
NanoImpact 2025 Jan;37:100537
NanoImpact 2025 Jan;37:100537
Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging.
Xu W, Yi S, Liu J, Jiang Y, Huang J
Nature communications 2025 Jan 2;16(1):8
Nature communications 2025 Jan 2;16(1):8
Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4.
Zhu XX, Su JB, Wang FM, Chai XY, Chen G, Xu AJ, Meng XY, Qiu HB, Sun QY, Wang Y, Lv ZL, Zhang Y, Liu Y, Han ZJ, Li N, Sun HJ, Lu QB
Clinical and translational medicine 2025 Feb;15(2):e70221
Clinical and translational medicine 2025 Feb;15(2):e70221
Exposure to Manganese Induces Autophagy-Lysosomal Pathway Dysfunction-Mediated Tauopathy by Activating the cGAS-STING Pathway in the Brain.
Zhang X, Liu J, Zhong S, Zhang Z, Zhou Q, Yang J, Chang X, Wang H
Environment & health (Washington, D.C.) 2025 Feb 21;3(2):199-212
Environment & health (Washington, D.C.) 2025 Feb 21;3(2):199-212
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050
Pharmacological research 2025 Dec;222:108050
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy.
Zhang S, Guo J, Liu M, Chen Y, Shen X, Wang J, Deng X, Guan S
Journal of dairy science 2025 Aug;108(8):7896-7911
Journal of dairy science 2025 Aug;108(8):7896-7911
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230
Free radical biology & medicine 2025 Aug 1;235:213-230
Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy.
Wang Y, Ding L, Wang Y, Li H, Wu M, Li S, Xu Q, Chen Y, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156483
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
Rosell A, Krygowska AA, Alcón Pérez M, Cuesta C, Voisin MB, de Paz J, Sanz-Fraile H, Rajeeve V, Carreras-González A, Berral-González A, Swinyard O, Gabandé-Rodríguez E, Downward J, Alcaraz J, Anguita J, García-Macías C, De Las Rivas J, Cutillas PR, Castellano Sanchez E
eLife 2025 Apr 24;13
eLife 2025 Apr 24;13
Cathepsin B promotes optic nerve axonal regeneration.
Zhang S, Zhu H, Li G, Zhu M
Neuroreport 2025 Apr 2;36(6):279-289
Neuroreport 2025 Apr 2;36(6):279-289
Alumina nanoparticles induce learning and memory impairment in a particle size-dependent and time-dependent manner.
Zhang Y, Jia L, Wang Z, Guo W, Qin X, Ge C, Niu Q, Zhang Q
Ecotoxicology and environmental safety 2025 Apr 15;295:118177
Ecotoxicology and environmental safety 2025 Apr 15;295:118177
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Lu J, Su P, Zhao F, Yu K, Yang X, Lv H, Wang D, Zhang J
Current research in toxicology 2024;7:100193
Current research in toxicology 2024;7:100193
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Guo Y, Wang S, Liu Q, Dong Y, Liu Y
PloS one 2024;19(12):e0316268
PloS one 2024;19(12):e0316268
Identification and validation of three diagnostic autophagy-related genes associated with advanced plaques and immune cell infiltration in carotid atherosclerosis based on integrated bioinformatics analyses.
Huang T, Su C, Su Q, Nie Y, Xiao Z, Tang Y, Wang J, Luo X, Tang Y
PeerJ 2024;12:e18543
PeerJ 2024;12:e18543
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
Wang ML, Zhang YJ, He DL, Li T, Zhao MM, Zhao LM
Biochemical pharmacology 2024 Sep;227:116438
Biochemical pharmacology 2024 Sep;227:116438
Acteoside delays the fibrosis process of diabetic nephropathy by anti-oxidation and regulating the autophagy-lysosome pathway.
Zhou M, Zhang S, Bai X, Cai Y, Zhang Z, Zhang P, Xue C, Zheng H, Sun Q, Han D, Lou L, Wang Y, Liu W
European journal of pharmacology 2024 Sep 5;978:176715
European journal of pharmacology 2024 Sep 5;978:176715
An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal.
Wisner SR, Chlebowski M, Mandal A, Mai D, Stein C, Petralia RS, Wang YX, Drerup CM
Autophagy 2024 Oct;20(10):2275-2296
Autophagy 2024 Oct;20(10):2275-2296
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, Lin C, Ji KT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
Staphylococcus aureus promotes its intracellular survival by inhibiting Rab11-Rab11FIP4-mediated vesicle trafficking.
Xu H, Wang X, Zhang Z, Hu J, Yu Y, Wang J, Liu Y, Liu J
Veterinary microbiology 2024 Jun;293:110091
Veterinary microbiology 2024 Jun;293:110091
MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice.
Ma H, Ou ZL, Alaeiilkhchi N, Cheng YQ, Chen K, Chen JY, Guo RQ, He MY, Tang SY, Zhang X, Huang ZP, Liu J, Liu J, Zhu QA, Huang ZC, Jiang H
Lipids in health and disease 2024 Jun 22;23(1):194
Lipids in health and disease 2024 Jun 22;23(1):194
scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network.
Li C, Shao X, Zhang S, Wang Y, Jin K, Yang P, Lu X, Fan X, Wang Y
Cell reports. Medicine 2024 Jun 18;5(6):101568
Cell reports. Medicine 2024 Jun 18;5(6):101568
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase.
Lou Y, Li Z, Zheng H, Yuan Z, Li W, Zhang J, Shen W, Gao Y, Ran N, Kong X, Feng S
International immunopharmacology 2024 Jun 15;134:112190
International immunopharmacology 2024 Jun 15;134:112190
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Ren Y, Wu H, Tan M, Chen J, Duan Z, Zhu B, Ruan X, Yu Q, Li S, Liu X, Liu Y, Si Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Guo Y, Wang S, Dong Y, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.
Gu R, Bai L, Yan F, Zhang S, Zhang X, Deng R, Zeng X, Sun B, Hu X, Li Y, Bai J
Cell death discovery 2024 Feb 22;10(1):93
Cell death discovery 2024 Feb 22;10(1):93
Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin.
Mao B, Le-Trilling VTK, Tang H, Hu J, Schmitz MS, Barbet K, Xu D, Wei Z, Guo B, Mennerich D, Yao C, Liu J, Li Z, Wan Y, Zhang X, Wang K, Tang N, Yu Z, Trilling M, Lin Y
Virus research 2024 Dec;350:199485
Virus research 2024 Dec;350:199485
Discovery of sp(3)-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors.
Miura K, Doi T, Umedera K, Nakamura H
European journal of medicinal chemistry 2024 Dec 15;280:116923
European journal of medicinal chemistry 2024 Dec 15;280:116923
Mitochondria-specific antioxidant MitoTEMPO alleviates senescence of bone marrow mesenchymal stem cells in ovariectomized rats.
Li J, Zhang D, Zhang Y, Ge J, Yang C
Journal of cellular physiology 2024 Aug;239(8):e31323
Journal of cellular physiology 2024 Aug;239(8):e31323
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, He W, Zhu N, Hu Z, Hao H, Zhu H, Zhao S
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin‑mediated NLRP3 inflammasome activation.
Zheng L, Mei W, Zhou J, Wei X, Huang Z, Lin X, Zhang L, Liu W, Wu Q, Li J, Yan Y
Experimental and therapeutic medicine 2024 Apr;27(4):142
Experimental and therapeutic medicine 2024 Apr;27(4):142
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Guan S, Qu X, Wang J, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B.
Cao W, Chen X, Xiao C, Lin D, Li Y, Luo S, Zeng Z, Sun B, Lei S
Aging 2023 Sep 26;15(18):9377-9390
Aging 2023 Sep 26;15(18):9377-9390
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD
bioRxiv : the preprint server for biology 2023 May 28;
bioRxiv : the preprint server for biology 2023 May 28;
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
Hao Y, Song T, Wang M, Li T, Zhao C, Li T, Hou Y, He H
International journal of oncology 2023 Mar;62(3)
International journal of oncology 2023 Mar;62(3)
Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage.
Gai C, Zhao Y, Xin D, Li T, Cheng Y, Jiang Z, Song Y, Liu D, Wang Z
Cells 2023 Mar 9;12(6)
Cells 2023 Mar 9;12(6)
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Pei X, Liu D, Li J, Li L, Ding X, Zhang W, Li Z, Xu G, Li C, Li D
The Science of the total environment 2023 Mar 20;865:161242
The Science of the total environment 2023 Mar 20;865:161242
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.
Rowland LA, Guilherme A, Henriques F, DiMarzio C, Munroe S, Wetoska N, Kelly M, Reddig K, Hendricks G, Pan M, Han X, Ilkayeva OR, Newgard CB, Czech MP
Nature communications 2023 Mar 13;14(1):1362
Nature communications 2023 Mar 13;14(1):1362
The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
E Y, Yu Q, Sun T, Xue H, Zhao XR, Zheng HC
BMC cancer 2023 Jun 8;23(1):520
BMC cancer 2023 Jun 8;23(1):520
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J
Research square 2023 Jun 15;
Research square 2023 Jun 15;
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Zhang Z, Pi R, Jiang Y, Ahmad M, Luo H, Luo J, Yang J, Sun B
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
3, 14, 19-Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg-AD mice by inducing initiation and promoting degradation process of autophagy.
Zhang H, Xie X, Shi J, Zhao Q, Luo D, Hao J, Zhou Y, Han G, Pang X
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Phytotherapy research : PTR 2023 Feb;37(2):410-423
Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats.
Hasegawa T, Tokunaga S, Yamamoto T, Sakai M, Hongo H, Kawata T, Amizuka N
Endocrinology 2023 Feb 11;164(4)
Endocrinology 2023 Feb 11;164(4)
The cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells.
Zuppone S, Zarovni N, Vago R
Drug delivery 2023 Dec;30(1):2162161
Drug delivery 2023 Dec;30(1):2162161
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics.
Zhang X, Liang B, Huang Y, Meng H, Li Z, Du J, Zhou L, Zhong Y, Wang B, Lin X, Yu G, Chen X, Lu W, Chen ZS, Yang X, Huang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303753
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B.
Yan W, Feng Y, Lei Z, Kuang W, Long C
Folia biologica 2022;68(2):78-85
Folia biologica 2022;68(2):78-85
Blockade of Autophagy Prevents the Progression of Hyperuricemic Nephropathy Through Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.
Hu Y, Shi Y, Chen H, Tao M, Zhou X, Li J, Ma X, Wang Y, Liu N
Frontiers in immunology 2022;13:858494
Frontiers in immunology 2022;13:858494
Polystyrene micro(nano)plastics damage the organelles of RBL-2H3 cells and promote MOAP-1 to induce apoptosis.
Liu L, Liu B, Zhang B, Ye Y, Jiang W
Journal of hazardous materials 2022 Sep 15;438:129550
Journal of hazardous materials 2022 Sep 15;438:129550
In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways.
Lei J, Zhao J, Long MY, Cao XW, Wang FJ
Chemico-biological interactions 2022 Sep 1;364:110058
Chemico-biological interactions 2022 Sep 1;364:110058
Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor.
Jiang T, Xu C, Gao S, Zhang J, Zheng J, Wu X, Lu Q, Cao L, Yang D, Xu J, Chen X
NPJ Parkinson's disease 2022 Oct 6;8(1):127
NPJ Parkinson's disease 2022 Oct 6;8(1):127
Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells.
Tianji L, Dingbang H, Xiao C, Xiaojing M, Fei Z, Bin W
Toxicology letters 2022 Mar 1;357:73-83
Toxicology letters 2022 Mar 1;357:73-83
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer.
Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y, Ding W, Zhu J, Lin Z, Zhong L, Wang J, Yue P, Turkson J, Liu P, Wang Y, Zhang X
Redox biology 2022 Jun;52:102317
Redox biology 2022 Jun;52:102317
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy.
Sun J, Li Y, Yang X, Dong W, Yang J, Hu Q, Zhang C, Fang H, Liu A
Aging cell 2022 Jan;21(1):e13532
Aging cell 2022 Jan;21(1):e13532
Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice.
Li MM, Wang X, Chen XD, Yang HL, Xu HS, Zhou P, Gao R, Zhang N, Wang J, Jiang L, Liu N
Behavioural brain research 2022 Aug 26;432:113987
Behavioural brain research 2022 Aug 26;432:113987
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Yu YW, Que JQ, Liu S, Huang KY, Qian L, Weng YB, Rong FN, Wang L, Zhou YY, Xue YJ, Ji KT
Frontiers in cardiovascular medicine 2021;8:768214
Frontiers in cardiovascular medicine 2021;8:768214
CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells.
Peng S, Yang Q, Li H, Pan Y, Wang J, Hu P, Zhang N
International journal of medical sciences 2021;18(6):1484-1491
International journal of medical sciences 2021;18(6):1484-1491
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Xie D, Zhao T, Zhang X, Kui L, Wang Q, Wu Y, Zheng T, Ma P, Zhang Y, Molteni H, Geng R, Yang Y, Li B, Zheng QY
Frontiers in cellular neuroscience 2021;15:753369
Frontiers in cellular neuroscience 2021;15:753369
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway.
Zuo SQ, Li C, Liu YL, Tan YH, Wan X, Xu T, Li Q, Wang L, Wu YL, Deng FM, Tang B
FEBS open bio 2021 Oct;11(10):2705-2714
FEBS open bio 2021 Oct;11(10):2705-2714
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy.
Yuan L, Chu B, Chen S, Li Y, Liu N, Zhu Y, Zhou D
Microorganisms 2021 Nov 16;9(11)
Microorganisms 2021 Nov 16;9(11)
MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.
Jiang L, Qiu T, Yao X, Chen H, Yao K, Sun X, Yang G, Jiang L, Zhang C, Wang N, Zhang H, Liu X
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
Environmental science and pollution research international 2021 Dec;28(47):66628-66642
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.
Gu Y, Zhu Y, Deng G, Liu S, Sun Y, Lv W
International immunopharmacology 2021 Apr;93:107375
International immunopharmacology 2021 Apr;93:107375
A proteomic approach towards understanding the pathogenesis of Mooren's ulcer.
Chi H, Hao W, Qi X, Zhang T, Dong Y, Gao H, Wei C, Shi W
Experimental eye research 2021 Apr;205:108509
Experimental eye research 2021 Apr;205:108509
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
Hu J, Ding X, Tian S, Chu Y, Liu Z, Li Y, Li X, Wang G, Wang L, Wang Z
Cell death & disease 2021 Apr 12;12(4):391
Cell death & disease 2021 Apr 12;12(4):391
Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop.
Wang SY, Ni X, Hu KQ, Meng FL, Li M, Ma XL, Meng TT, Wu HH, Ge D, Zhao J, Li Y, Su GH
International journal of biological sciences 2020;16(11):2001-2013
International journal of biological sciences 2020;16(11):2001-2013
Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat.
Jia G, Meng Z, Liu C, Ma X, Gao J, Liu J, Guo R, Yan Z, Christopher T, Lopez B, Liu W, Dai H, Lau WB, Jiao X, Zhao J, Wang ZX, Cao J, Wang Y
Life sciences 2020 Sep 15;257:118084
Life sciences 2020 Sep 15;257:118084
Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.
Cui X, Feng R, Wang J, Du C, Pi X, Chen D, Li J, Li H, Zhang J, Zhang J, Mu H, Zhang F, Liu M, Hu Y
Biochimica et biophysica acta. General subjects 2020 Mar;1864(3):129496
Biochimica et biophysica acta. General subjects 2020 Mar;1864(3):129496
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV Jr, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ
Nature 2020 Dec;588(7838):459-465
Nature 2020 Dec;588(7838):459-465
GILT restricts the cellular entry mediated by the envelope glycoproteins of SARS-CoV, Ebola virus and Lassa fever virus.
Chen D, Hou Z, Jiang D, Zheng M, Li G, Zhang Y, Li R, Lin H, Chang J, Zeng H, Guo JT, Zhao X
Emerging microbes & infections 2019;8(1):1511-1523
Emerging microbes & infections 2019;8(1):1511-1523
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Sheng J, Shen L, Sun L, Zhang X, Cui R, Wang L
Cell proliferation 2019 May;52(3):e12609
Cell proliferation 2019 May;52(3):e12609
Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB.
He R, Shi X, Zhou M, Zhao Y, Pan S, Zhao C, Guo X, Wang M, Li X, Qin R
Toxicology and applied pharmacology 2018 Oct 1;356:159-171
Toxicology and applied pharmacology 2018 Oct 1;356:159-171
Promotion of autophagosome-lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease.
Shi X, Sun R, Zhao Y, Fu R, Wang R, Zhao H, Wang Z, Tang F, Zhang N, Tian X, Yao J
RSC advances 2018 May 30;8(36):20411-20422
RSC advances 2018 May 30;8(36):20411-20422
Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration.
Dong Y, Xu M, Kalueff AV, Song C
European journal of nutrition 2018 Aug;57(5):1781-1791
European journal of nutrition 2018 Aug;57(5):1781-1791
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy.
Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, Lin B, Wang G, Wang Z, Sun W, Sun M, Chang S, Cai Z, Hua Y
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A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells.
Fu W, Li X, Lu X, Zhang L, Li R, Zhang N, Liu S, Yang X, Wang Y, Zhao Y, Meng X, Zhu WG
Cell death & disease 2017 Oct 5;8(10):e3086
Cell death & disease 2017 Oct 5;8(10):e3086
Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells.
Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S
Oncotarget 2017 Oct 10;8(47):81880-81891
Oncotarget 2017 Oct 10;8(47):81880-81891
The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.
Wang D, Zhang J, Jiang W, Cao Z, Zhao F, Cai T, Aschner M, Luo W
Autophagy 2017 May 4;13(5):914-927
Autophagy 2017 May 4;13(5):914-927
Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux.
Xie X, Yi W, Zhang P, Wu N, Yan Q, Yang H, Tian C, Xiang S, Du M, Getachew Assefa E, Zuo X, Ying C
Nutrients 2017 May 14;9(5)
Nutrients 2017 May 14;9(5)
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Sun T, Jiang D, Zhang L, Su Q, Mao W, Jiang C
Oncology letters 2016 Jan;11(1):575-583
Oncology letters 2016 Jan;11(1):575-583
Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.
Yan Y, Zhou K, Wang L, Zhou Y, Chen X, Fan Q
International journal of clinical and experimental pathology 2015;8(9):10102-11
International journal of clinical and experimental pathology 2015;8(9):10102-11
Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection.
Xiang Y, Yan C, Guo X, Zhou K, Li S, Gao Q, Wang X, Zhao F, Liu J, Lee WH, Zhang Y
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6702-7
Proceedings of the National Academy of Sciences of the United States of America 2014 May 6;111(18):6702-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 12216-1-AP(CTSB antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 12216-1-AP(CTSB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Cathepsin B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cathepsin B. This antibody recognizes human, mouse antigen. The Cathepsin B antibody has been validated for the following applications: ELISA, WB, IHC analysis.
