Tissue expression
Cell line expression

CTSB

gene product
 
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
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691 antibodies from 41 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Novus Biologicals
68 antibodies
R&D Systems
7 antibodies
Invitrogen Antibodies
17 antibodies
NovoPro Bioscience Inc.
4 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
GeneTex
9 antibodies
antibodies-online
190 antibodies
Aviva Systems Biology
6 antibodies
Atlas Antibodies
1 antibody
LifeSpan BioSciences, Inc.
116 antibodies
OriGene
8 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Cell Signaling Technology, Inc
5 antibodies
Abgent
3 antibodies
Enzo Life Sciences
2 antibodies
Biorbyt
37 antibodies
HUABIO Research
3 antibodies
Affinity Biosciences
2 antibodies
Acris Antibodies GmbH
7 antibodies
Boster Biological Technology
3 antibodies
Bioworld Technology, Inc
2 antibodies
ProSci
1 antibody
RabMAbs
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Abnova Corporation
5 antibodies
NSJ Bioreagents
2 antibodies
Creative Diagnostics
9 antibodies
MyBioSource
13 antibodies
BioLegend
1 antibody
Sino Biological Inc.
1 antibody
Abbexa
15 antibodies
Creative Biolabs
45 antibodies
RayBiotech, Inc.
2 antibodies
Leading Biology
2 antibodies
United States Biological
64 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
EMD Millipore
1 antibody
Molecular Innovations
1 antibody
GenWay
6 antibodies