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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [9]
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- Product number
- MAB9521 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human/Mouse Cathepsin L Monoclonal Antibody (Clone 204101)
- Antibody type
- Monoclonal
- Antigen
- Mouse myeloma cell line NS0-derived recombinant human Cathepsin L, Glu113-Val333
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human, Mouse
- Host
- Rat
- Antigen sequence
P07711- Isotype
- IgG
- Vial size
- 500 µg
Submitted references A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.
CCT complex restricts neuropathogenic protein aggregation via autophagy.
The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.
Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.
Stat3 controls lysosomal-mediated cell death in vivo.
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer.
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF
Science advances 2016 Sep;2(9):e1601167
Science advances 2016 Sep;2(9):e1601167
CCT complex restricts neuropathogenic protein aggregation via autophagy.
Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC
Nature communications 2016 Dec 8;7:13821
Nature communications 2016 Dec 8;7:13821
The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.
Pensa S, Neoh K, Resemann HK, Kreuzaler PA, Abell K, Clarke NJ, Reinheckel T, Kahn CR, Watson CJ
Cell death and differentiation 2014 Sep;21(9):1442-50
Cell death and differentiation 2014 Sep;21(9):1442-50
Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.
O'Brien J, Martinson H, Durand-Rougely C, Schedin P
Development (Cambridge, England) 2012 Jan;139(2):269-75
Development (Cambridge, England) 2012 Jan;139(2):269-75
Stat3 controls lysosomal-mediated cell death in vivo.
Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ
Nature cell biology 2011 Mar;13(3):303-9
Nature cell biology 2011 Mar;13(3):303-9
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Oct;24(10):3744-55
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Oct;24(10):3744-55
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
Lopez-Castejon G, Theaker J, Pelegrin P, Clifton AD, Braddock M, Surprenant A
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2611-9
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2611-9
Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer.
Parker BS, Ciocca DR, Bidwell BN, Gago FE, Fanelli MA, George J, Slavin JL, Möller A, Steel R, Pouliot N, Eckhardt B, Henderson MA, Anderson RL
The Journal of pathology 2008 Feb;214(3):337-46
The Journal of pathology 2008 Feb;214(3):337-46
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL
The Journal of biological chemistry 2006 Jun 9;281(23):15893-9
The Journal of biological chemistry 2006 Jun 9;281(23):15893-9
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