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- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 11194-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11194-1-AP, RRID:AB_2224414
- Product name
- AKR1C3 antibody
- Antibody type
- Polyclonal
- Description
- AKR1C3 antibody (Cat. #11194-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A New Histology-Based Prognostic Index for Acute Lymphoblastic Leukemia: Preliminary Results of the "ALL Urayasu Classification".
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway.
Exosomal miR-184 facilitates bladder cancer progression by targeting AKR1C3 and inducing immune escape via IRF2-CXCL10 axis.
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5.
AKR1C3 promotes progression and mediates therapeutic resistance by inducing epithelial-mesenchymal transition and angiogenesis in small cell lung cancer.
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Prostaglandin F(2α) synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F(2α)-dependent and F(2α)-independent mechanism.
Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia.
AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer.
15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines.
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Maruo S, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Noguchi M
Journal of clinical medicine 2026 Jan 17;15(2)
Journal of clinical medicine 2026 Jan 17;15(2)
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway.
Yuan X, Long L, Wang M, Chen W, Liang B, Xu L, Wang W, Li C
Drug design, development and therapy 2025;19:4641-4664
Drug design, development and therapy 2025;19:4641-4664
Exosomal miR-184 facilitates bladder cancer progression by targeting AKR1C3 and inducing immune escape via IRF2-CXCL10 axis.
Ying W, Zhao Y, He Y, Deng Y, Gan X, Li P, Chen X, Ding Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167627
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167627
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2025 Mar 15;14(6)
Journal of clinical medicine 2025 Mar 15;14(6)
AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5.
Ju F, Weng J, Fan N, Wang Z, Zhou C, Zhao X, Horstmann N, Wu X, Hoppe S, You B, Li K, Duan J, Odenthal M, Hillmer AM, Quaas A, Bruns CJ, Zhao Y
Cell death & disease 2025 Jul 2;16(1):483
Cell death & disease 2025 Jul 2;16(1):483
AKR1C3 promotes progression and mediates therapeutic resistance by inducing epithelial-mesenchymal transition and angiogenesis in small cell lung cancer.
Liu W, Li G, Huang D, Qin T
Translational oncology 2024 Sep;47:102027
Translational oncology 2024 Sep;47:102027
m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Ochiai T, Furuya C, Araki Y, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2024 Jun 30;13(13)
Journal of clinical medicine 2024 Jun 30;13(13)
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Huang W, Wang Y, Huang W
Neuroscience letters 2024 Jan 31;821:137608
Neuroscience letters 2024 Jan 31;821:137608
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2023 Sep 30;12(19)
Journal of clinical medicine 2023 Sep 30;12(19)
Prostaglandin F(2α) synthase promotes oxaliplatin resistance in colorectal cancer through prostaglandin F(2α)-dependent and F(2α)-independent mechanism.
Wang YJ, Xie XL, Liu HQ, Tian H, Jiang XY, Zhang JN, Chen SX, Liu T, Wang SL, Zhou X, Jin XX, Liu SM, Jiang HQ
World journal of gastroenterology 2023 Oct 21;29(39):5452-5470
World journal of gastroenterology 2023 Oct 21;29(39):5452-5470
Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Liu Y, Chen Y, Jiang J, Chu X, Guo Q, Zhao L, Feng F, Liu W, Zhang X, He S, Yang P, Fang P, Sun H
European journal of medicinal chemistry 2023 Feb 5;247:115013
European journal of medicinal chemistry 2023 Feb 5;247:115013
Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia.
Blaize JL, Noori BM, Hunter KP, Henrikson KA, Atoyan JA, Ardito AA, Donovan FX, Chandrasekharappa SC, Schindler D, Howlett NG
bioRxiv : the preprint server for biology 2023 Apr 27;
bioRxiv : the preprint server for biology 2023 Apr 27;
AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer.
Liu C, Yang JC, Armstrong CM, Lou W, Liu L, Qiu X, Zou B, Lombard AP, D'Abronzo LS, Evans CP, Gao AC
Molecular cancer therapeutics 2019 Oct;18(10):1875-1886
Molecular cancer therapeutics 2019 Oct;18(10):1875-1886
15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines.
Li H, Narahara H
International journal of molecular medicine 2013 Apr;31(4):778-88
International journal of molecular medicine 2013 Apr;31(4):778-88
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 11194-1-AP(AKR1C3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 11194-1-AP(AKR1C3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AKR1C3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AKR1C3. This antibody recognizes human antigen. The AKR1C3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
