60042-1-Ig

antibody from Proteintech Group

Targeting: CXCR4 CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Provider product page for 60042-1-Ig

Western blot

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [76]
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Validations
Western blot [1]

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Product number: 60042-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60042-1-Ig, RRID:AB_2091809
Product name: CXCR4 antibody
Antibody type: Monoclonal
Description: KD/KO validated CXCR4 antibody (Cat. #60042-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgM
Antibody clone number: 4B5E4
Vial size: 20ul, 150ul

CXCR4 protein structure - 60042-1-Ig shown in red.

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The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells.

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ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.

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Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling.

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Cell death & disease 2021 Feb 26;12(2):214

The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.

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CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation.

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Molecular therapy oncolytics 2020 Sep 25;18:161-170

Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells.

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DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.

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Evidence-based complementary and alternative medicine : eCAM 2019;2019:7912402

Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells.

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OncoTargets and therapy 2019;12:3849-3858

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Inflammation 2019 Jun;42(3):874-883

CXCR4 regulates Plasmodium development in mouse and human hepatocytes.

Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M
The Journal of experimental medicine 2019 Aug 5;216(8):1733-1748

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Cytotechnology 2018 Oct;70(5):1409-1422

Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy.

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ACS applied materials & interfaces 2018 Jul 11;10(27):22963-22973

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International journal of molecular medicine 2018 Feb;41(2):969-976

CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.

Shi A, Shi H, Dong L, Xu S, Jia M, Guo X, Wang T
Scandinavian journal of gastroenterology 2017 Jun-Jul;52(6-7):745-753

Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.

Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y
Molecular cancer research : MCR 2017 Jul;15(7):884-895

Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery system of gold nanorods for targeted photothermal therapy of gastric cancer.

Yang M, Liu Y, Hou W, Zhi X, Zhang C, Jiang X, Pan F, Yang Y, Ni J, Cui D
Nanoscale 2017 Jan 7;9(1):334-340

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635

Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.

Liu R, Wang W, Dai B, Liu Y, Zhang Y
Molecular medicine reports 2015 Nov;12(5):7735-41

Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.

Zhang Y, Zhan Y, Zhang D, Dai B, Ma W, Qi J, Liu R, He L
Scientific reports 2014 Jul 1;4:5518

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CXCR4 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human CXCR4. This antibody recognizes human, mouse antigen. The CXCR4 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 60042-1-Ig.pdf

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