60042-1-Ig

antibody from Proteintech Group

Targeting: CXCR4 CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Provider product page for 60042-1-Ig

Western blot

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [44]
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Validations
Western blot [1]

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Product number: 60042-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60042-1-Ig, RRID:AB_2091809
Product name: CXCR4 antibody
Antibody type: Monoclonal
Description: KD/KO validated CXCR4 antibody (Cat. #60042-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgM
Antibody clone number: 4B5E4
Vial size: 20ul, 150ul

CXCR4 protein structure - 60042-1-Ig shown in red.

Submitted references ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth.

He Y, Qu Y, Jin S, Zhang Y, Qin L
Oral diseases 2024 Oct;30(7):4231-4242

Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.

Zhang M, Zhang J, Hu H, Zhou Y, Lin Z, Jing H, Sun B
Journal of translational medicine 2024 Jun 27;22(1):598

Study on the mechanism of CXCL12/CXCR4-axis-mediated upregulation of IL-8 and IL-6 on the biological function of acute T lymphocyte leukaemia cells.

Zhou L, Zhao H, Zhang C, Chen Z, Li D, Qian G
Cytotechnology 2024 Feb;76(1):97-111

DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis.

Wang SY, Zhang SJ, Meng HF, Xu HQ, Guo ZX, Yan JF, Gao JL, Niu LN, Wang SL, Jiao K
Stem cell research & therapy 2024 Apr 23;15(1):113

Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment.

Zhang Y, Han X, Wang K, Liu D, Ding X, Hu Z, Wang J
International journal of nanomedicine 2023;18:4329-4346

CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients.

Chen J, Bai Y, Xue K, Li Z, Zhu Z, Li Q, Yu C, Li B, Shen S, Qiao P, Li C, Luo Y, Qiao H, Dang E, Yin W, Gudjonsson JE, Wang G, Shao S
Nature communications 2023 Sep 22;14(1):5894

Duan JL, Liu JJ, Ruan B, Ding J, Fang ZQ, Xu H, Song P, Xu C, Li ZW, Du W, Xu M, Ling YW, He F, Wang L
Nature aging 2023 Mar;3(3):258-274

Tissue-resident CXCR4(+) macrophage as a poor prognosis signature promotes pancreatic ductal adenocarcinoma progression.

Liao Z, Ye L, Li T, Jin X, Lin X, Fei Q, Zhang H, Shi S, Yu X, Jin K, Wu W
International journal of cancer 2023 Jun 1;152(11):2396-2409

CXCR4-Targeted Necrosis-Inducing Peptidomimetic for Treating Breast Cancer.

Akonnor A, Makise M, Kuniyasu A
ACS omega 2023 Jul 11;8(27):24467-24476

CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.

Ma J, Dong L, Chang Q, Chen S, Zheng J, Li D, Wu S, Yang H, Li X
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166597

Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1.

Zhao J, Lin E, Bai Z, Jia Y, Wang B, Dai Y, Zhuo W, Zeng G, Liu X, Cai C, Li P, Zou B, Li J
BMC cancer 2023 Dec 6;23(1):1198

TCF12 regulates exosome release from epirubicin-treated CAFs to promote ER+ breast cancer cell chemoresistance.

Qiu Y, Wang X, Sun Y, Du YE, Yin G, Luo H, Wen S, Lang L, Liu M, Tang X
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166727

TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.

Li Y, Xue M, Deng X, Dong L, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, Qing Y, Shen C, Tan B, Chen Z, Leung K, Wang K, Swaminathan S, Li L, Wunderlich M, Mulloy JC, Li X, Chen H, Zhang B, Horne D, Rosen ST, Marcucci G, Xu M, Li Z, Wei M, Tian J, Shen B, Su R, Chen J
Cell stem cell 2023 Aug 3;30(8):1072-1090.e10

Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer.

Li J, Yu T, Sun J, Zeng Z, Liu Z, Ma M, Zheng Z, He Y, Kang W
Aging 2023 Apr 7;15(7):2772-2796

Interaction of immune checkpoint PD-1 and chemokine receptor 4 (CXCR4) promotes a malignant phenotype in pancreatic cancer cells.

Harper MM, Lin M, Cavnar MJ, Pandalai PK, Patel RA, Gao M, Kim J
PloS one 2022;17(7):e0270832

Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.

Ma W, Wan Y, Zhang J, Yao J, Wang Y, Lu J, Liu H, Huang X, Zhang X, Zhou H, He Y, Wu D, Wang J, Zhao Y
Molecular oncology 2022 Oct;16(20):3720-3734

Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.

Wu N, Chen S, Luo Q, Jiang Z, Wang X, Li Y, Qiu J, Yu K, Yang Y, Zhuang J
Experimental eye research 2022 Mar;216:108955

CXCR4 inhibition attenuates calcium oxalate crystal deposition-induced renal fibrosis.

Ye Z, Xia Y, Zhou X, Li B, Yu W, Ruan Y, Li H, Ning J, Chen L, Rao T, Cheng F
International immunopharmacology 2022 Jun;107:108677

Identification of a novel prognostic signature for HCC and analysis of costimulatory molecule-related lncRNA AC099850.3.

Wang Q, Fang Q, Huang Y, Zhou J, Liu M
Scientific reports 2022 Jun 15;12(1):9954

Zedoarondiol inhibits atherosclerosis by regulating monocyte migration and adhesion via CXCL12/CXCR4 pathway.

Chai H, Qu H, He S, Song L, Yang Y, Huang H, Shi D
Pharmacological research 2022 Aug;182:106328

Enhanced CXCL12/CXCR4 signaling increases tumor progression in radiation‑resistant pancreatic cancer.

Kato T, Matsuo Y, Ueda G, Murase H, Aoyama Y, Omi K, Hayashi Y, Imafuji H, Saito K, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
Oncology reports 2022 Apr;47(4)

MiR-1236-3p Inhibits the Proliferation, Invasion, and Migration of Colon Cancer Cells and Hinders Epithelial-Mesenchymal Transition by Targeting DCLK3.

Zhao Y, Zhou H, Shen J, Yang S, Deng K, Li Q, Cui W
Frontiers in oncology 2021;11:688882

Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4.

Chi JY, Hsiao YW, Liu HL, Fan XJ, Wan XB, Liu TL, Hung SJ, Chen YT, Liang HY, Wang JM
Cell death discovery 2021 May 6;7(1):94

ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.

Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W, Zhou H, Gao Y, Li X, Liu Z
Cell death discovery 2021 May 29;7(1):126

AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.

Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476

Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling.

Wang Y, Lan W, Xu M, Song J, Mao J, Li C, Du X, Jiang Y, Li E, Zhang R, Wang Q
Cell death & disease 2021 Feb 26;12(2):214

The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.

Ni W, Zhang Y, Yin Z
Regenerative therapy 2021 Dec;18:255-267

CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation.

Zhou J, Le K, Xu M, Ming J, Yang W, Zhang Q, Lu L, Xi Z, Ruan S, Huang T
Molecular therapy oncolytics 2020 Sep 25;18:161-170

Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells.

Lin YS, Tsai KL, Chen JN, Wu CS
Environmental toxicology 2020 Oct;35(10):1070-1081

The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer.

Peng L, Wang Y, Fei S, Wei C, Tong F, Wu G, Ma H, Dong X
Translational lung cancer research 2020 Jun;9(3):745-760

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.

Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138

Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells.

Shi WL, Zhao J, Yuan R, Lu Y, Xin QQ, Liu Y, Cong WH, Chen KJ
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7912402

Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells.

Yang M, Zeng C, Li P, Qian L, Ding B, Huang L, Li G, Jiang H, Gong N, Wu W
OncoTargets and therapy 2019;12:3849-3858

The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.

Cheng Y, Yin B, Hou T, Chen T, Ping J
Journal of cellular physiology 2019 Sep;234(9):16215-16225

Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.

Wu Y, Xu W, Hou J, Liu Y, Li R, Liu J, Li C, Tang X, Lin L, Pan Y, Zhang D
Inflammation 2019 Jun;42(3):874-883

CXCR4 regulates Plasmodium development in mouse and human hepatocytes.

Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M
The Journal of experimental medicine 2019 Aug 5;216(8):1733-1748

Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.

Luo Y, Mohsin A, Xu C, Wang Q, Hang H, Zhuang Y, Chu J, Guo M
Cytotechnology 2018 Oct;70(5):1409-1422

Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy.

Yang N, Ding Y, Zhang Y, Wang B, Zhao X, Cheng K, Huang Y, Taleb M, Zhao J, Dong WF, Zhang L, Nie G
ACS applied materials & interfaces 2018 Jul 11;10(27):22963-22973

CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.

Shi A, Shi H, Dong L, Xu S, Jia M, Guo X, Wang T
Scandinavian journal of gastroenterology 2017 Jun-Jul;52(6-7):745-753

Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.

Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y
Molecular cancer research : MCR 2017 Jul;15(7):884-895

Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery system of gold nanorods for targeted photothermal therapy of gastric cancer.

Yang M, Liu Y, Hou W, Zhi X, Zhang C, Jiang X, Pan F, Yang Y, Ni J, Cui D
Nanoscale 2017 Jan 7;9(1):334-340

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635

Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.

Liu R, Wang W, Dai B, Liu Y, Zhang Y
Molecular medicine reports 2015 Nov;12(5):7735-41

Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.

Zhang Y, Zhan Y, Zhang D, Dai B, Ma W, Qi J, Liu R, He L
Scientific reports 2014 Jul 1;4:5518

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CXCR4 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human CXCR4. This antibody recognizes human, mouse antigen. The CXCR4 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 60042-1-Ig.pdf

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