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Learn60042-1-Ig
antibody from Proteintech Group
Targeting: CXCR4
CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 60042-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60042-1-Ig, RRID:AB_2091809
- Product name
- CXCR4 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated CXCR4 antibody (Cat. #60042-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgM
- Antibody clone number
- 4B5E4
- Vial size
- 20ul, 150ul
Submitted references MiR-1236-3p Inhibits the Proliferation, Invasion, and Migration of Colon Cancer Cells and Hinders Epithelial-Mesenchymal Transition by Targeting DCLK3.
Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4.
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling.
The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.
CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation.
Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells.
The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer.
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells.
Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells.
Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.
The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.
CXCR4 regulates Plasmodium development in mouse and human hepatocytes.
Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.
Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy.
CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.
Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Zhao Y, Zhou H, Shen J, Yang S, Deng K, Li Q, Cui W
Frontiers in oncology 2021;11:688882
Frontiers in oncology 2021;11:688882
Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4.
Chi JY, Hsiao YW, Liu HL, Fan XJ, Wan XB, Liu TL, Hung SJ, Chen YT, Liang HY, Wang JM
Cell death discovery 2021 May 6;7(1):94
Cell death discovery 2021 May 6;7(1):94
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W, Zhou H, Gao Y, Li X, Liu Z
Cell death discovery 2021 May 29;7(1):126
Cell death discovery 2021 May 29;7(1):126
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling.
Wang Y, Lan W, Xu M, Song J, Mao J, Li C, Du X, Jiang Y, Li E, Zhang R, Wang Q
Cell death & disease 2021 Feb 26;12(2):214
Cell death & disease 2021 Feb 26;12(2):214
The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.
Ni W, Zhang Y, Yin Z
Regenerative therapy 2021 Dec;18:255-267
Regenerative therapy 2021 Dec;18:255-267
CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation.
Zhou J, Le K, Xu M, Ming J, Yang W, Zhang Q, Lu L, Xi Z, Ruan S, Huang T
Molecular therapy oncolytics 2020 Sep 25;18:161-170
Molecular therapy oncolytics 2020 Sep 25;18:161-170
Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells.
Lin YS, Tsai KL, Chen JN, Wu CS
Environmental toxicology 2020 Oct;35(10):1070-1081
Environmental toxicology 2020 Oct;35(10):1070-1081
The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer.
Peng L, Wang Y, Fei S, Wei C, Tong F, Wu G, Ma H, Dong X
Translational lung cancer research 2020 Jun;9(3):745-760
Translational lung cancer research 2020 Jun;9(3):745-760
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138
Nature 2020 Jul;583(7814):133-138
Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells.
Shi WL, Zhao J, Yuan R, Lu Y, Xin QQ, Liu Y, Cong WH, Chen KJ
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7912402
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7912402
Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells.
Yang M, Zeng C, Li P, Qian L, Ding B, Huang L, Li G, Jiang H, Gong N, Wu W
OncoTargets and therapy 2019;12:3849-3858
OncoTargets and therapy 2019;12:3849-3858
Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.
Wu Y, Xu W, Hou J, Liu Y, Li R, Liu J, Li C, Tang X, Lin L, Pan Y, Zhang D
Inflammation 2019 Jun;42(3):874-883
Inflammation 2019 Jun;42(3):874-883
The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.
Cheng Y, Yin B, Hou T, Chen T, Ping J
Journal of cellular physiology 2019 Feb 19;
Journal of cellular physiology 2019 Feb 19;
CXCR4 regulates Plasmodium development in mouse and human hepatocytes.
Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M
The Journal of experimental medicine 2019 Aug 5;216(8):1733-1748
The Journal of experimental medicine 2019 Aug 5;216(8):1733-1748
Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.
Luo Y, Mohsin A, Xu C, Wang Q, Hang H, Zhuang Y, Chu J, Guo M
Cytotechnology 2018 Oct;70(5):1409-1422
Cytotechnology 2018 Oct;70(5):1409-1422
Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy.
Yang N, Ding Y, Zhang Y, Wang B, Zhao X, Cheng K, Huang Y, Taleb M, Zhao J, Dong WF, Zhang L, Nie G
ACS applied materials & interfaces 2018 Jul 11;10(27):22963-22973
ACS applied materials & interfaces 2018 Jul 11;10(27):22963-22973
CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.
Shi A, Shi H, Dong L, Xu S, Jia M, Guo X, Wang T
Scandinavian journal of gastroenterology 2017 Jun - Jul;52(6-7):745-753
Scandinavian journal of gastroenterology 2017 Jun - Jul;52(6-7):745-753
Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.
Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y
Molecular cancer research : MCR 2017 Jul;15(7):884-895
Molecular cancer research : MCR 2017 Jul;15(7):884-895
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635
Nature communications 2016 May 18;7:11635
Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Liu R, Wang W, Dai B, Liu Y, Zhang Y
Molecular medicine reports 2015 Nov;12(5):7735-41
Molecular medicine reports 2015 Nov;12(5):7735-41
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Zhang Y, Zhan Y, Zhang D, Dai B, Ma W, Qi J, Liu R, He L
Scientific reports 2014 Jul 1;4:5518
Scientific reports 2014 Jul 1;4:5518
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CXCR4 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human CXCR4. This antibody recognizes human, mouse antigen. The CXCR4 antibody has been validated for the following applications: ELISA, WB analysis.
