ABIN343363

antibody from antibodies-online

Targeting: CXCR4 CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN343363

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN343363, RRID:AB_10788640

Product name

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide corresponding to a sequence at the N-terminal of human CXCR4, different to the related rat sequence by two amino acids.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100 µg

Storage

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.

References

Submitted references

Effect of short hairpin RNA-induced CXCR4 silence on ovarian cancer cell.

Chen HY, Wang JM, Wang HY, Zhang YX, Liu W, Pan L, Wang WH, Chen SF, Jin WG, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2012 Oct;66(7):549-53

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Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma.

Lin F, Zheng SE, Shen Z, Tang LN, Chen P, Sun YJ, Zhao H, Yao Y
Medical oncology (Northwood, London, England) 2011 Jun;28(2):649-53

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Silencing of CXCR4 blocks progression of ovarian cancer and depresses canonical Wnt signaling pathway.

Wang J, Cai J, Han F, Yang C, Tong Q, Cao T, Wu L, Wang Z
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2011 Aug;21(6):981-7

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Increased expression of SDF-1/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast.

Liu F, Lang R, Wei J, Fan Y, Cui L, Gu F, Guo X, Pringle GA, Zhang X, Fu L
Histopathology 2009 May;54(6):741-50

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The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells.

Ping YF, Yao XH, Chen JH, Liu H, Chen DL, Zhou XD, Wang JM, Bian XW
Journal of neuro-oncology 2007 Aug;84(1):21-9

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Cloning and characterizing mutated human stromal cell-derived factor-1 (SDF-1): C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling, but not in CXCR4 binding affinity.

Tan Y, Du J, Cai S, Li X, Ma W, Guo Z, Chen H, Huang Z, Xiao J, Cai L, Cai S
Experimental hematology 2006 Nov;34(11):1553-62

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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.

Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T
Nature 1998 Jun 11;393(6685):591-4