306501
antibody from BioLegend
Targeting: CXCR4
CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 306501 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#306501, RRID:AB_314607
- Product name
- Purified anti-human CD184 (CXCR4)
- Antibody type
- Monoclonal
- Antigen
- CD184 (CXCR4)
- Description
- CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E
Blood 2010 Jun 17;115(24):5026-36
Blood 2010 Jun 17;115(24):5026-36
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX
The Journal of biological chemistry 2007 Mar 30;282(13):9547-55
The Journal of biological chemistry 2007 Mar 30;282(13):9547-55
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified 12G5, followed by biotinylated anti-mouse IgG and Sav-PE
- Conjugate
- Unconjugated