306512

antibody from BioLegend

Targeting: CXCR4 CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Immunocytochemistry

Immunohistochemistry

Blocking/Neutralizing

Antibody data

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Validation data

Product number: 306512 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#306512, RRID:AB_2292651
Product name: LEAF™ Purified anti-human CD184 (CXCR4) [12G5]
Antibody type: Monoclonal
Antigen: CD184 (CXCR4)
Description: CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 500 µg
Concentration: 1 mg/ml
Storage: The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

CXCR4 protein structure - 306512 shown in red.