NB100-56437
antibody from Novus Biologicals
Targeting: CXCR4
CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB100-56437 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56437, RRID:AB_837929
- Product name
- Rabbit Polyclonal CXCR4 Antibody
- Antibody type
- Polyclonal
- Description
- Protein G purified. In HeLa, a 45 kDa band is observed.
- Reactivity
- Human, Mouse, Rat, Sheep
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Autocrine signals increase ovine mesenchymal stem cells migration through Aquaporin-1 and CXCR4 overexpression.
Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination.
Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis.
CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.
CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2.
Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465.
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.
Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family.
HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration.
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene.
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene.
Expression of stem cell markers in human astrocytomas of different WHO grades.
Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures.
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion.
The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells.
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
Journal of cellular physiology 2018 Aug;233(8):6241-6249
Journal of cellular physiology 2018 Aug;233(8):6241-6249
Multifaceted C-X-C Chemokine Receptor 4 (CXCR4) Inhibition Interferes with Anti-Vascular Endothelial Growth Factor Therapy-Induced Glioma Dissemination.
Gagner JP, Sarfraz Y, Ortenzi V, Alotaibi FM, Chiriboga LA, Tayyib AT, Douglas GJ, Chevalier E, Romagnoli B, Tuffin G, Schmitt M, Lemercier G, Dembowsky K, Zagzag D
The American journal of pathology 2017 Sep;187(9):2080-2094
The American journal of pathology 2017 Sep;187(9):2080-2094
Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis.
Irie Y, Tsubota M, Ishikura H, Sekiguchi F, Terada Y, Tsujiuchi T, Liu K, Nishibori M, Kawabata A
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2017 Dec;12(4):693-707
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2017 Dec;12(4):693-707
CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.
Dieckow J, Brandt W, Hattermann K, Schob S, Schulze U, Mentlein R, Ackermann P, Sel S, Paulsen FP
Investigative ophthalmology & visual science 2016 Jan 1;57(1):56-65
Investigative ophthalmology & visual science 2016 Jan 1;57(1):56-65
CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2.
Ghosh MC, Makena PS, Gorantla V, Sinclair SE, Waters CM
American journal of physiology. Lung cellular and molecular physiology 2012 May 1;302(9):L846-56
American journal of physiology. Lung cellular and molecular physiology 2012 May 1;302(9):L846-56
Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465.
De Silva RA, Peyre K, Pullambhatla M, Fox JJ, Pomper MG, Nimmagadda S
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 Jun;52(6):986-93
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 Jun;52(6):986-93
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.
Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG
Cancer research 2010 May 15;70(10):3935-44
Cancer research 2010 May 15;70(10):3935-44
Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family.
Hogg K, Etherington SL, Young JM, McNeilly AS, Duncan WC
Endocrinology 2010 Mar;151(3):1247-56
Endocrinology 2010 Mar;151(3):1247-56
HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration.
Esencay M, Newcomb EW, Zagzag D
Journal of neuro-oncology 2010 Aug;99(1):33-40
Journal of neuro-oncology 2010 Aug;99(1):33-40
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene.
Pacheco-Rodriguez G, Kumaki F, Steagall WK, Zhang Y, Ikeda Y, Lin JP, Billings EM, Moss J
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1270-7
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1270-7
Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene.
Pacheco-Rodriguez G, Kumaki F, Steagall WK, Zhang Y, Ikeda Y, Lin JP, Billings EM, Moss J
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1270-7
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1270-7
Expression of stem cell markers in human astrocytomas of different WHO grades.
Ma YH, Mentlein R, Knerlich F, Kruse ML, Mehdorn HM, Held-Feindt J
Journal of neuro-oncology 2008 Jan;86(1):31-45
Journal of neuro-oncology 2008 Jan;86(1):31-45
Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures.
Zagzag D, Esencay M, Mendez O, Yee H, Smirnova I, Huang Y, Chiriboga L, Lukyanov E, Liu M, Newcomb EW
The American journal of pathology 2008 Aug;173(2):545-60
The American journal of pathology 2008 Aug;173(2):545-60
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion.
Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW
Laboratory investigation; a journal of technical methods and pathology 2006 Dec;86(12):1221-32
Laboratory investigation; a journal of technical methods and pathology 2006 Dec;86(12):1221-32
The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells.
Kulbe H, Hagemann T, Szlosarek PW, Balkwill FR, Wilson JL
Cancer research 2005 Nov 15;65(22):10355-62
Cancer research 2005 Nov 15;65(22):10355-62
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL
Cancer research 2005 Jul 15;65(14):6178-88
Cancer research 2005 Jul 15;65(14):6178-88
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: CXCR4 Antibody [NB100-56437] - Detection of 15 ug in HeLa cells with antibody concentration at 1 ug/mL.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: CXCR4 Antibody [NB100-56437] - CXCR4 was detected in immersion sections of human tonsil using rabbit anti-human antibody (Catalog # NB100-56437) at 1:300 dilution overnight at 4C. Tissue was stained using the VisuCyte anti-rabbit HRP polymer detection reagent with DAB chromogen (brown) and counterstained with hematoxylin (blue).