ABIN493378

antibody from antibodies-online

Targeting: PSEN2 AD3L, AD4, PS2, STM2

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN493378

Provider

antibodies-online

Product name

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) antibody

Antibody type

Polyclonal

Antigen

The PSEN2-selective antibodies were generated against unique antigenic sequences form near N-terminal peptides for the presenilin 2 gene.

Description

Affinity Chromatography on immobilized antigen

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

Storage

Store the antibody undiluted (in aliquots) at-20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 7;103(6):1941-6

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Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Hansson CA, Popescu BO, Laudon H, Cedazo-Minguez A, Popescu LM, Winblad B, Ankarcrona M
Journal of neurochemistry 2006 Apr;97(2):356-64