PSEN2

gene product
AD3L, AD4, PS2, STM2
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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405 antibodies from 37 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
33 antibodies
Invitrogen Antibodies
3 antibodies
GeneTex
12 antibodies
antibodies-online
162 antibodies
Biorbyt
21 antibodies
Cell Signaling Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
LifeSpan BioSciences, Inc.
40 antibodies
Affinity Biosciences
2 antibodies
Bethyl Laboratories
1 antibody
OriGene
4 antibodies
Abnova Corporation
5 antibodies
Aviva Systems Biology
3 antibodies
Boster Biological Technology
1 antibody
NSJ Bioreagents
1 antibody
ProSci
4 antibodies
R&D Systems
4 antibodies
Abgent
7 antibodies
RabMAbs
6 antibodies
St John's Laboratory
2 antibodies
Acris Antibodies GmbH
15 antibodies
Creative Biolabs
18 antibodies
Creative Diagnostics
5 antibodies
BioLegend
2 antibodies
MyBioSource
8 antibodies
FabGennix
3 antibodies
United States Biological
8 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Abiocode, Inc.
1 antibody
RayBiotech, Inc.
1 antibody
GenWay
6 antibodies
EMD Millipore
1 antibody
Proteintech Group
1 antibody
Abbexa
3 antibodies
Sigma-Aldrich
3 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody