Tissue expression
Cell line expression
Protein structure
PSEN2
Presenilin 2AD3L, AD4, PS2, STM2
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | MA1-754 | 4 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
|
GeneTex | GTX15549 | Monoclonal |
WB
EL
ICC
IP
IHC
|
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Novus Biologicals | NB100-74513 | Monoclonal |
WB
EL
ICC
IP
IHC
|
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NSJ Bioreagents | RQ6264 | Polyclonal |
WB
ICC
IHC
FC |
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Boster Biological Technology | A00800 | Polyclonal |
WB
ICC
IHC
FC |
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider