Tissue expression
Cell line expression

PSEN2

gene product
AD3L, AD4, PS2, STM2 
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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450 antibodies from 39 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
19 antibodies
Novus Biologicals
33 antibodies
GeneTex
12 antibodies
NSJ Bioreagents
2 antibodies
antibodies-online
162 antibodies
Boster Biological Technology
3 antibodies
Biorbyt
21 antibodies
OriGene
5 antibodies
LifeSpan BioSciences, Inc.
42 antibodies
Cell Signaling Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Affinity Biosciences
2 antibodies
Bethyl Laboratories
1 antibody
Proteintech Group
1 antibody
Abnova Corporation
5 antibodies
Aviva Systems Biology
3 antibodies
ProSci
4 antibodies
R&D Systems
4 antibodies
Abgent
7 antibodies
RabMAbs
6 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Acris Antibodies GmbH
15 antibodies
Creative Diagnostics
6 antibodies
BioLegend
2 antibodies
MyBioSource
8 antibodies
FabGennix
3 antibodies
Creative Biolabs
21 antibodies
United States Biological
8 antibodies
Leading Biology
6 antibodies
Abbexa
9 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Abiocode, Inc.
1 antibody
RayBiotech, Inc.
1 antibody
GenWay
6 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
EMD Millipore
1 antibody
BioLegend (formerly Covance Antibody Products)
1 antibody