Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS9179 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Bag 4 (V442) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 411-460 of Human Bag-4.
- Description
- The cytokine TNF (tumor necrosis factor) signals through the TNF-R1 receptor to activate various cellular pathways, including apoptosis and NFkB activation. TNF binding induces receptor aggregation, resulting in the recruitment of TRADD, FADD, TRAF2 and RIP to the intracellular ¡ùdeath¡ì domain of the receptor complex, which in turn activates signaling pathways including apoptosis and NFkB activation. SODD, for silencer of death domains, was found to be associated with the intracellular ¡ùdeath¡ì domain of TNF-R1 in the absence of TNF stimulation. TNF treatment results in the release of SODD from TNF-R1, allowing the recruitment of TRADD and TRAF2 to the receptor complex. Thus, SODD may play a role in preventing spontaneous signaling by death-domain receptors, in the absence of ligand.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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