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- Antigen structure
- References [28]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17520-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17520-1-AP, RRID:AB_2176561
- Product name
- PTCH1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTCH1 antibody (Cat. #17520-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A Pilot Immunohistochemical Study Identifies Hedgehog Pathway Expression in Sinonasal Adenocarcinoma.
SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches.
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.
RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines.
A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.
Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression.
Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes.
Anti-apoptotic effect of the Shh signaling pathway in cigarette smoke extract induced MLE 12 apoptosis.
Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin.
Promotion of Axon Growth by the Secreted End of a Transcription Factor.
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
FMRP Modulates Neural Differentiation through m(6)A-Dependent mRNA Nuclear Export.
Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling.
Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway.
Co-expression analysis revealed PTCH1-3'UTR promoted cell migration and invasion by activating miR-101-3p/SLC39A6 axis in non-small cell lung cancer: implicating the novel function of PTCH1.
Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway.
Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas.
The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction.
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.
PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target.
Expression pattern of sonic hedgehog signaling and calcitonin gene-related peptide in the socket healing process after tooth extraction.
GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation.
Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.
Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.
Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation.
Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.
MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1.
Leović M, Jakovčević A, Mumlek I, Zagorac I, Sabol M, Leović D
International journal of molecular sciences 2024 Apr 24;25(9)
International journal of molecular sciences 2024 Apr 24;25(9)
SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches.
Wu Q, Tian P, He D, Jia Z, He Y, Luo W, Lv X, Wang Y, Zhang P, Liang Y, Zhao W, Qin J, Su P, Jiang YZ, Shao ZM, Yang Q, Hu G
Cell research 2023 Jun;33(6):464-478
Cell research 2023 Jun;33(6):464-478
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.
Li Y, Wang H, Sun B, Su G, Cang Y, Zhao L, Zhao S, Li Y, Mao B, Ma P
Cell death & disease 2023 Aug 3;14(8):494
Cell death & disease 2023 Aug 3;14(8):494
RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines.
Kurtović M, Piteša N, Bartoniček N, Ozretić P, Musani V, Čonkaš J, Petrić T, King C, Sabol M
Cancers 2022 Sep 19;14(18)
Cancers 2022 Sep 19;14(18)
A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.
Chung KM, Kim H, Roque CG, McCurdy EP, Nguyen TTT, Siegelin MD, Hwang JY, Hengst U
Cell reports 2022 Oct 18;41(3):111488
Cell reports 2022 Oct 18;41(3):111488
Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression.
Li Y, Yang C, Wang H, Zhao L, Kong Q, Cang Y, Zhao S, Lv L, Li Y, Mao B, Ma P
Journal of molecular cell biology 2022 Apr 5;14(1)
Journal of molecular cell biology 2022 Apr 5;14(1)
Histone H1 improves regeneration after mouse spinal cord injury and changes shape and gene expression of cultured astrocytes.
Kleene R, Loers G, Jakovcevski I, Mishra B, Schachner M
Restorative neurology and neuroscience 2019;37(4):291-313
Restorative neurology and neuroscience 2019;37(4):291-313
Anti-apoptotic effect of the Shh signaling pathway in cigarette smoke extract induced MLE 12 apoptosis.
Li J, Zong D, Chen Y, Chen P
Tobacco induced diseases 2019;17:49
Tobacco induced diseases 2019;17:49
Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin.
Deng Q, Li P, Che M, Liu J, Biswas S, Ma G, He L, Wei Z, Zhang Z, Yang Y, Liu H, Li B
eLife 2019 Sep 4;8
eLife 2019 Sep 4;8
Promotion of Axon Growth by the Secreted End of a Transcription Factor.
McCurdy EP, Chung KM, Benitez-Agosto CR, Hengst U
Cell reports 2019 Oct 8;29(2):363-377.e5
Cell reports 2019 Oct 8;29(2):363-377.e5
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863
Nature communications 2019 Jun 28;10(1):2863
FMRP Modulates Neural Differentiation through m(6)A-Dependent mRNA Nuclear Export.
Edens BM, Vissers C, Su J, Arumugam S, Xu Z, Shi H, Miller N, Rojas Ringeling F, Ming GL, He C, Song H, Ma YC
Cell reports 2019 Jul 23;28(4):845-854.e5
Cell reports 2019 Jul 23;28(4):845-854.e5
Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling.
Matsumoto K, Shimo T, Kurio N, Okui T, Ibaragi S, Kunisada Y, Obata K, Masui M, Pai P, Horikiri Y, Yamanaka N, Takigawa M, Sasaki A
Journal of cellular biochemistry 2018 Jun;119(6):4352-4360
Journal of cellular biochemistry 2018 Jun;119(6):4352-4360
Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.
Song L, Chen X, Wang P, Gao S, Qu C, Liu L
Acta biochimica et biophysica Sinica 2018 Jun 1;50(6):586-596
Acta biochimica et biophysica Sinica 2018 Jun 1;50(6):586-596
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway.
Zhuang H, Cao G, Kou C, Liu T
Oncology reports 2018 Jan;39(1):21-30
Oncology reports 2018 Jan;39(1):21-30
Co-expression analysis revealed PTCH1-3'UTR promoted cell migration and invasion by activating miR-101-3p/SLC39A6 axis in non-small cell lung cancer: implicating the novel function of PTCH1.
Wan X, Kong Z, Chu K, Yi C, Hu J, Qin R, Zhao C, Fu F, Wu H, Li Y, Huang Y
Oncotarget 2018 Jan 12;9(4):4798-4813
Oncotarget 2018 Jan 12;9(4):4798-4813
Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway.
Song K, Zheng G, Zhao Y
Cell biology international 2018 Aug;42(8):994-1005
Cell biology international 2018 Aug;42(8):994-1005
Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas.
Ozretić P, Trnski D, Musani V, Maurac I, Kalafatić D, Orešković S, Levanat S, Sabol M
International journal of oncology 2017 Dec;51(6):1869-1877
International journal of oncology 2017 Dec;51(6):1869-1877
The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction.
Shimo T, Matsumoto K, Takabatake K, Aoyama E, Takebe Y, Ibaragi S, Okui T, Kurio N, Takada H, Obata K, Pang P, Iwamoto M, Nagatsuka H, Sasaki A
PloS one 2016;11(3):e0151731
PloS one 2016;11(3):e0151731
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.
Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X
Nature communications 2016 Apr 4;7:11151
Nature communications 2016 Apr 4;7:11151
PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target.
Gurung B, Hua X, Runske M, Bennett B, LiVolsi V, Roses R, Fraker DA, Metz DC
Cancer biology & therapy 2015;16(2):219-24
Cancer biology & therapy 2015;16(2):219-24
Expression pattern of sonic hedgehog signaling and calcitonin gene-related peptide in the socket healing process after tooth extraction.
Pang P, Shimo T, Takada H, Matsumoto K, Yoshioka N, Ibaragi S, Sasaki A
Biochemical and biophysical research communications 2015 Nov 6;467(1):21-6
Biochemical and biophysical research communications 2015 Nov 6;467(1):21-6
GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation.
Trnski D, Sabol M, Gojević A, Martinić M, Ozretić P, Musani V, Ramić S, Levanat S
Biochimica et biophysica acta 2015 Dec;1852(12):2574-84
Biochimica et biophysica acta 2015 Dec;1852(12):2574-84
Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.
Zhang L, Zhou Y, Cheng C, Cui H, Cheng L, Kong P, Wang J, Li Y, Chen W, Song B, Wang F, Jia Z, Li L, Li Y, Yang B, Liu J, Shi R, Bi Y, Zhang Y, Wang J, Zhao Z, Hu X, Yang J, Li H, Gao Z, Chen G, Huang X, Yang X, Wan S, Chen C, Li B, Tan Y, Chen L, He M, Xie S, Li X, Zhuang X, Wang M, Xia Z, Luo L, Ma J, Dong B, Zhao J, Song Y, Ou Y, Li E, Xu L, Wang J, Xi Y, Li G, Xu E, Liang J, Yang X, Guo J, Chen X, Zhang Y, Li Q, Liu L, Li Y, Zhang X, Yang H, Lin D, Cheng X, Guo Y, Wang J, Zhan Q, Cui Y
American journal of human genetics 2015 Apr 2;96(4):597-611
American journal of human genetics 2015 Apr 2;96(4):597-611
Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.
Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J
Cancer biology & therapy 2014 May;15(5):544-59
Cancer biology & therapy 2014 May;15(5):544-59
Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation.
Hung HC, Hsiao YH, Gean PW
The international journal of neuropsychopharmacology 2014 Dec 13;18(3)
The international journal of neuropsychopharmacology 2014 Dec 13;18(3)
Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.
Gurung B, Feng Z, Hua X
Molecular cancer research : MCR 2013 Oct;11(10):1215-22
Molecular cancer research : MCR 2013 Oct;11(10):1215-22
MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1.
Li Y, Zhang D, Chen C, Ruan Z, Li Y, Huang Y
Molecular biology of the cell 2012 Apr;23(8):1423-34
Molecular biology of the cell 2012 Apr;23(8):1423-34
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 17520-1-AP(PTCH1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17520-1-AP(PTCH1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTCH1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PTCH1. This antibody recognizes human, mouse antigen. The PTCH1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
