Tissue expression
Cell line expression

CLCF1

gene product
BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6 
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antigen sequence

Epitope

Antibody

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
250 antibodies from 25 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
3 antibodies
Atlas Antibodies
1 antibody
Novus Biologicals
25 antibodies
antibodies-online
75 antibodies
Invitrogen Antibodies
5 antibodies
R&D Systems
3 antibodies
LifeSpan BioSciences, Inc.
50 antibodies
Aviva Systems Biology
2 antibodies
Signalway Antibody LLC
1 antibody
PeproTech Inc.
8 antibodies
OriGene
4 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Biorbyt
14 antibodies
MyBioSource
8 antibodies
Abnova Corporation
3 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
Abbexa
3 antibodies
Cusabio Technology LLC
1 antibody
Proteintech Group
1 antibody
Acris Antibodies GmbH
8 antibodies
Creative Diagnostics
4 antibodies
United States Biological
14 antibodies
ProSci
3 antibodies
Creative Biolabs
6 antibodies