CXXC4

This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Description

CXXC finger protein 4

Tissue specificity

Tissue enhanced (brain, retina)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular

Protein family

Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (104468308 - 104494901)

Ensembl ID

ENSG00000168772  (ver. 103.38)

Orthologs

Mouse Cxxc4: ENSMUSG00000044365

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure