orb66795

antibody from Biorbyt

Targeting: SHH HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS

Western blot (Data presented on provider website)

Antibody Data

Product number

orb66795

Provider

Biorbyt

Product name

SHH antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC)receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE).Abberant activation of the SHH signaling pathway is associated with several types of cancer.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 ul

Storage

-20°C