SHH

gene product
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
530 antibodies from 36 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
137 antibodies
Novus Biologicals
32 antibodies
NovoPro Bioscience Inc.
9 antibodies
R&D Systems
8 antibodies
GeneTex
11 antibodies
OriGene
25 antibodies
Biorbyt
35 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
84 antibodies
Boster Biological Technology
2 antibodies
Affinity Biosciences
2 antibodies
Invitrogen Antibodies
8 antibodies
Acris Antibodies GmbH
17 antibodies
Abgent
7 antibodies
NSJ Bioreagents
5 antibodies
Arigo
4 antibodies
Aviva Systems Biology
2 antibodies
Enzo Life Sciences
2 antibodies
St John's Laboratory
4 antibodies
RabMAbs
2 antibodies
Cell Signaling Technology, Inc
3 antibodies
ProSci
1 antibody
Creative Biolabs
52 antibodies
Creative Diagnostics
8 antibodies
Abnova Corporation
7 antibodies
United States Biological
20 antibodies
EMD Millipore
2 antibodies
MyBioSource
9 antibodies
Spring Bioscience
4 antibodies
Abiocode, Inc.
3 antibodies
Sigma-Aldrich
7 antibodies
Abbiotec
2 antibodies
BioLegend
1 antibody
RayBiotech, Inc.
1 antibody
GenWay
1 antibody