BS6430

antibody from Bioworld Technology, Inc
Targeting: FAS APO-1, APT1, CD95, FAS1, TNFRSF6
Provider product page for BS6430
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6430 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CD95/FAS polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CD95/FAS.
Description
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno- surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FAS protein structure - BS6430 shown in red.