Tissue expression
Cell line expression
Protein structure

FAS

Fas cell surface death receptor
APO-1, APT1, CD95, FAS1, TNFRSF6 
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
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2979 antibodies from 53 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
6 antibodies
Invitrogen Antibodies
108 antibodies
antibodies-online
928 antibodies
GeneTex
41 antibodies
R&D Systems
27 antibodies
Novus Biologicals
226 antibodies
Enzo Life Sciences
11 antibodies
Acris Antibodies GmbH
74 antibodies
Atlas Antibodies
1 antibody
OriGene
87 antibodies
NovoPro Bioscience Inc.
19 antibodies
NSJ Bioreagents
11 antibodies
Boster Biological Technology
5 antibodies
Abnova Corporation
40 antibodies
Affinity Biosciences
3 antibodies
FineTest Biotech
2 antibodies
Abgent
11 antibodies
Cell Signaling Technology, Inc
2 antibodies
HUABIO Research
2 antibodies
St John's Laboratory
22 antibodies
Bioworld Technology, Inc
5 antibodies
Everest Biotech
1 antibody
BioLegend
53 antibodies
Cusabio Biotech Co., Ltd
13 antibodies
Aviva Systems Biology
15 antibodies
PeproTech Inc.
8 antibodies
Creative Diagnostics
23 antibodies
RabMAbs
4 antibodies
ProSci
9 antibodies
Antibodies.com
1 antibody
Bethyl Laboratories
1 antibody
Abbkine Scientific Co.Ltd.
4 antibodies
ABEOMICS Inc.
2 antibodies
GenWay
36 antibodies
Abbexa
37 antibodies
Miltenyi Biotec
38 antibodies
Sino Biological Inc.
13 antibodies
MyBioSource
19 antibodies
Leading Biology
13 antibodies
Spring Bioscience
4 antibodies
Creative Biolabs
262 antibodies
RayBiotech, Inc.
6 antibodies
Exalpha Biologicals, Inc.
2 antibodies
Absolute Antibody
6 antibodies
EMD Millipore
6 antibodies
MilliporeSigma / Merck KGaA
10 antibodies
Signalway Antibody LLC
1 antibody
United States Biological
205 antibodies
eBioscience, An Affymetrix Company
31 antibodies
CPTAC
1 antibody