Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 305702 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#305702, RRID:AB_314554
- Product name
- Purified anti-human CD95 (Fas)
- Antibody type
- Monoclonal
- Antigen
- CD95
- Description
- CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6. It is a member of the TNF receptor superfamily. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils and fibroblasts. CD95 expression is upregulated by activation. The extracellular region of CD95 binds to CD178 (Fas ligand). CD178 binding to CD95 induces apoptosis, and has been shown to play a role in the maintenance of peripheral tolerance. The EOS9.1 antibody is useful for inducing apoptosis of Fas-positive cells.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgM
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY
Molecular cancer therapeutics 2008 Jul;7(7):2212-23
Molecular cancer therapeutics 2008 Jul;7(7):2212-23
The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 1;178(1):474-9
Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 1;178(1):474-9
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified EOS9.1, followed by anti-mouse IgM PE
- Conjugate
- Unconjugated