Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12410-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12410-1-AP, RRID:AB_2108692
- Product name
- GABRA1 antibody
- Antibody type
- Polyclonal
- Description
- GABRA1 antibody (Cat. #12410-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1.
Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA(A)R α1 Expression.
Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.
The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system.
Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus.
Gut microbiome-derived ammonia modulates stress vulnerability in the host.
Triptolide injection reduces Alzheimer's disease-like pathology in mice.
Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis.
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Amelioration of olfactory dysfunction in a mouse model of Parkinson's disease via enhancing GABAergic signaling.
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation.
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Rare variants in GABRG2 associated with sleep-related hypermotor epilepsy.
MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series.
Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Autism-Like Behavior in the Offspring of CYP11A1-Overexpressing Pregnant Rats.
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1.
Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei.
PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.
Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model.
STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
As a Histone Deacetylase Inhibitor, γ-Aminobutyric Acid Upregulates GluR2 Expression: An In Vitro and In Vivo Study.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Transgenic overexpression of furin increases epileptic susceptibility.
The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.
Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X(2) receptors in progesterone-induced acrosome reaction and male fertility.
c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.
Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.
Wang M, Gu Y, Li Q, Feng B, Lv X, Zhang H, Kong Q, Dong Z, Tian X, Zhang Y
Genes & diseases 2024 May;11(3):100997
Genes & diseases 2024 May;11(3):100997
Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA(A)R α1 Expression.
Jiang ZF, Xuan LN, Sun XW, Liu SB, Yin J
Molecular neurobiology 2024 Mar;61(3):1404-1416
Molecular neurobiology 2024 Mar;61(3):1404-1416
Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.
Yao X, Chen R, Chen H, Koleske A, Xiao X
Behavioural brain research 2024 Jun 25;468:115022
Behavioural brain research 2024 Jun 25;468:115022
The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system.
Rong M, Jia JJ, Lin MQ, He XL, Xie ZY, Wang N, Zhang ZH, Dong YJ, Xu WF, Huang JH, Li B, Jiang NH, Lv GY, Chen SH
Chinese medicine 2024 Jun 12;19(1):84
Chinese medicine 2024 Jun 12;19(1):84
Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus.
Ren P, Wang JY, Chen HL, Wang Y, Cui LY, Duan JY, Guo WZ, Zhao YQ, Li YF
Journal of pharmacological sciences 2024 Apr;154(4):236-245
Journal of pharmacological sciences 2024 Apr;154(4):236-245
Gut microbiome-derived ammonia modulates stress vulnerability in the host.
Wang P, Wu PF, Wang HJ, Liao F, Wang F, Chen JG
Nature metabolism 2023 Nov;5(11):1986-2001
Nature metabolism 2023 Nov;5(11):1986-2001
Triptolide injection reduces Alzheimer's disease-like pathology in mice.
Mao R, Xu S, Sun G, Yu Y, Zuo Z, Wang Y, Yang K, Zhang Z, Yang W
Synapse (New York, N.Y.) 2023 May;77(3):e22261
Synapse (New York, N.Y.) 2023 May;77(3):e22261
Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis.
Chandra PK, Braun SE, Maity S, Castorena-Gonzalez JA, Kim H, Shaffer JG, Cikic S, Rutkai I, Fan J, Guidry JJ, Worthylake DK, Li C, Abdel-Mageed AB, Busija DW
Viruses 2023 Mar 21;15(3)
Viruses 2023 Mar 21;15(3)
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Klimas A, Gallagher BR, Wijesekara P, Fekir S, DiBernardo EF, Cheng Z, Stolz DB, Cambi F, Watkins SC, Brody SL, Horani A, Barth AL, Moore CI, Ren X, Zhao Y
Nature biotechnology 2023 Jun;41(6):858-869
Nature biotechnology 2023 Jun;41(6):858-869
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H
eLife 2023 Jun 5;12
eLife 2023 Jun 5;12
Amelioration of olfactory dysfunction in a mouse model of Parkinson's disease via enhancing GABAergic signaling.
Liu XY, Wang K, Deng XH, Wei YH, Guo R, Liu SF, Zhu YF, Zhong JJ, Zheng JY, Wang MD, Ye QH, He JQ, Guo KH, Zhu JR, Huang SQ, Chen ZX, Lv CS, Wen L
Cell & bioscience 2023 Jun 3;13(1):101
Cell & bioscience 2023 Jun 3;13(1):101
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Loukil A, Ebright E, Uezu A, Gao Y, Soderling SH, Goetz SC
bioRxiv : the preprint server for biology 2023 Dec 21;
bioRxiv : the preprint server for biology 2023 Dec 21;
Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation.
Auta J, Locci A, Guidotti A, Davis JM, Dong H
Current research in neurobiology 2022;3:100025
Current research in neurobiology 2022;3:100025
Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.
Liu X, Zhang L, Zhang H, Liang X, Zhang B, Tu J, Zhao Y
Frontiers in molecular neuroscience 2022;15:919718
Frontiers in molecular neuroscience 2022;15:919718
KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.
Xu Y, Lian Y, Li J, Zhang Y, Liu Y, Wang X, Ma J, Li F
Frontiers in pharmacology 2022;13:939169
Frontiers in pharmacology 2022;13:939169
Rare variants in GABRG2 associated with sleep-related hypermotor epilepsy.
Jiang YL, Song CG, Zhou HM, Feng B, Zhao JJ, Liu Y, Man YL, Han J, Liu SB, Jiang W
Journal of neurology 2022 Sep;269(9):4939-4954
Journal of neurology 2022 Sep;269(9):4939-4954
MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series.
Deng B, Cai M, Qiu Y, Liu X, Yu H, Zhang X, Huang H, Zhao X, Yang W, Dong S, Jin L, Chu S, Chen X
Neurology(R) neuroimmunology & neuroinflammation 2022 May;9(3)
Neurology(R) neuroimmunology & neuroinflammation 2022 May;9(3)
Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
Stein CS, McLendon JM, Witmer NH, Boudreau RL
Molecular therapy. Nucleic acids 2022 Jun 14;28:1-15
Molecular therapy. Nucleic acids 2022 Jun 14;28:1-15
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Popek M, Bobula B, Orzeł-Gajowik K, Zielińska M
International journal of molecular sciences 2022 Jan 19;23(3)
International journal of molecular sciences 2022 Jan 19;23(3)
Autism-Like Behavior in the Offspring of CYP11A1-Overexpressing Pregnant Rats.
Pan T, Jiang C, Cheng J, Xie J, Liu X, Xu W, He G
Frontiers in neuroscience 2021;15:774439
Frontiers in neuroscience 2021;15:774439
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Wang H, Yang H, Shi Y, Xiao Y, Yin Y, Jiang B, Ren H, Chen W, Xue Q, Xu X
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1.
Wang L, Liu Y, Yu Z, Gong J, Deng Z, Ren N, Zhong Z, Cai H, Tang Z, Cheng H, Chen S, He Z
Journal of translational medicine 2021 May 17;19(1):213
Journal of translational medicine 2021 May 17;19(1):213
Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei.
Jiang J, Jiao Y, Gao P, Yin W, Zhou W, Zhang Y, Liu Y, Wen D, Wang Y, Zhou L, Yu T, Yu W
Acta biochimica et biophysica Sinica 2021 Jul 28;53(8):1076-1087
Acta biochimica et biophysica Sinica 2021 Jul 28;53(8):1076-1087
PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.
Jiang C, Wang Z, Donnelly CR, Wang K, Andriessen AS, Tao X, Matsuda M, Zhao J, Ji RR
iScience 2020 Oct 23;23(10):101570
iScience 2020 Oct 23;23(10):101570
Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model.
Shao J, Zheng X, Qu L, Zhang H, Yuan H, Hui J, Mi Y, Ma P, Fan D
Food & function 2020 Feb 26;11(2):1245-1257
Food & function 2020 Feb 26;11(2):1245-1257
STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
Yang J, Jiang Q, Yu X, Xu T, Wang Y, Deng J, Liu Y, Chen Y
CNS neuroscience & therapeutics 2020 Aug;26(8):851-861
CNS neuroscience & therapeutics 2020 Aug;26(8):851-861
As a Histone Deacetylase Inhibitor, γ-Aminobutyric Acid Upregulates GluR2 Expression: An In Vitro and In Vivo Study.
Xing A, Li X, Jiang C, Chen Y, Wu S, Zhang J, An L
Molecular nutrition & food research 2019 Sep;63(17):e1900001
Molecular nutrition & food research 2019 Sep;63(17):e1900001
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.
Mo J, Wang B, Zhu X, Wu X, Liu Y
Neurobiology of disease 2019 Jan;121:274-285
Neurobiology of disease 2019 Jan;121:274-285
Transgenic overexpression of furin increases epileptic susceptibility.
Yang Y, He M, Tian X, Guo Y, Liu F, Li Y, Zhang H, Lu X, Xu D, Zhou R, Ma Y, Wang W, Chen G, Hu Y, Wang X
Cell death & disease 2018 Oct 17;9(11):1058
Cell death & disease 2018 Oct 17;9(11):1058
The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.
Zhang Y, Gao B, Zheng F, Lu S, Li Y, Xiong Y, Yang Q, Yang Y, Fu P, Xiao F, Wang X
Frontiers in molecular neuroscience 2017;10:100
Frontiers in molecular neuroscience 2017;10:100
Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X(2) receptors in progesterone-induced acrosome reaction and male fertility.
Xu W, Wang K, Chen Y, Liang XT, Yu MK, Yue H, Tierney ML
Reproduction, fertility, and development 2017 Sep;29(10):2060-2072
Reproduction, fertility, and development 2017 Sep;29(10):2060-2072
c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.
Wang R, Zhang W, Dong Z, Qi Y, Hultström M, Zhou X, Lai EY
Acta physiologica (Oxford, England) 2017 Feb;219(2):494-509
Acta physiologica (Oxford, England) 2017 Feb;219(2):494-509
Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.
Chen HH, Cheng PW, Ho WY, Lu PJ, Lai CC, Tseng YM, Fang HC, Sun GC, Hsiao M, Liu CP, Tseng CJ
Scientific reports 2016 Dec 5;6:38447
Scientific reports 2016 Dec 5;6:38447
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GABRA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GABRA1. This antibody recognizes human, mouse, rat antigen. The GABRA1 antibody has been validated for the following applications: ELISA, WB analysis.