CNKSR2

This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Description

Connector enhancer of kinase suppressor of Ras 2

Tissue specificity

Group enriched (brain, retina)

Subcell location

Golgi apparatus, Plasma membrane

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X:p22.12 (21372801 - 21654695)

Ensembl ID

ENSG00000149970  (ver. 103.38)

Orthologs

Mouse Cnksr2: ENSMUSG00000025658

UniProt

Q8WXI2

neXtProt

NX_Q8WXI2

Human splice variants
Mouse splice variants