BS4820

antibody from Bioworld Technology, Inc

Targeting: PDLIM5 Enh, LIM

Western blot (Data presented on provider website)

Antibody Data

Product number

BS4820

Provider

Bioworld Technology, Inc

Product name

PDLIM5 (phospho Y251) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human PDLIM5 around the phosphorylation site of Tyrosine 251.

Description

PDLIM5 (PDZ and LIM domain 5), also known as L9, ENH (Enigma homolog),LIM or ENH1, is a member of the Enigma family of proteins. Proteins belonging to this family contain an N-terminal PDZ (post-synaptic density-95/discs large/zone occludens-1) domain and one to three C-terminal LIM domains that typically associate with various isoforms of PKC (protein kinase C). Expressed in a wide variety of tissues, PDLIM5 contains three LIM zinc-binding domains and one PDZ domain. In the brain, PDLIM5 colocalizes with synaptic vesicles of neurotransmitters and regulates neuronal calcium signaling through an interaction with PKC š÷ and N-type Ca++ CP Ï«1B (N-type calcium channel Ï«1B subunit). Expression of PDLIM5 is often increased in the brain of patients with schizophrenia, major depression and bipolar disorder. This suggests that PDLIM5 may contribute to the genetic susceptibility of such conditions.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.