PDLIM5

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Description

PDZ and LIM domain 5

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Subcell location

Nucleoplasm, Plasma membrane, Focal adhesion sites

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4:q22.3 (94451857 - 94668227)

Ensembl ID

ENSG00000163110  (ver. 103.38)

Orthologs

Mouse Pdlim5: ENSMUSG00000028273

UniProt

Q96HC4

neXtProt

NX_Q96HC4

Human splice variants
Mouse splice variants