Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60257 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BBP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human BBP.
- Description
- Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the ÉÇ-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer£ªs disease. Proteolytic cleavage of APP leads to the formation of the Amyloid ÉÇ/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer£ªs patients. BBP (Beta-amyloid-binding protein), also known as TM2D1 (TM2 domain-containing protein 1), is a 207 amino acid multi-pass membrane protein containing a G protein-coupling module that allows for interaction with the ÉÇ-amyloid peptide of APP. In cell culture, expression of BBP induces caspase-dependent vulnerability to ÉÇ-amyloid peptide toxicity, suggesting that it is a target of ÉÇ-amyloid and may be involved in the molecular pathophysiology of Alzheimer£ªs disease.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of BBP pAb at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:Mouse kidney tissue lysate