TM2D1

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Description

TM2 domain containing 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (61681046 - 61725423)

Ensembl ID

ENSG00000162604  (ver. 103.38)

Orthologs

Mouse Tm2d1: ENSMUSG00000028563

UniProt

Q9BX74

neXtProt

NX_Q9BX74

Human splice variants
Mouse splice variants

Protein structure