SLC10A1

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

Description

Solute carrier family 10 member 1

Tissue specificity

Tissue enriched (liver)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

14 (69775416 - 69797241)

Ensembl ID

ENSG00000100652  (ver. 103.38)

Orthologs

Mouse Slc10a1: ENSMUSG00000021135

UniProt

Q14973

neXtProt

NX_Q14973

Human splice variants
Mouse splice variants

Protein structure