20423-1-AP

antibody from Proteintech Group

Targeting: ACKR3 CMKOR1, CXCR7, GPR159, RDC1

Provider product page for 20423-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Western blot [1]

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Product number: 20423-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20423-1-AP, RRID:AB_10693619
Product name: CXCR7 antibody
Antibody type: Polyclonal
Description: KD/KO validated CXCR7 antibody (Cat. #20423-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACKR3 protein structure - 20423-1-AP shown in red.

Submitted references TC14012 enhances the anti-fibrosis effects of UC-MSCs on the liver by reducing collagen accumulation and ameliorating inflammation.

Ding F, Liu Y, Li J, Wei X, Zhao J, Liu X, Zhang L
Stem cell research & therapy 2024 Feb 16;15(1):44

Circulating hsa_circ_0072309, acting via the miR-100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non-small-cell lung cancer.

Zhang XQ, Song Q, Zeng LX
Cancer medicine 2023 Sep;12(17):18005-18019

Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons.

Kim SK, Tran LT, NamKoong C, Choi HJ, Chun HJ, Lee YH, Cheon M, Chung C, Hwang J, Lim HH, Shin DM, Choi YH, Kim KW
Nature communications 2023 Jul 19;14(1):4321

Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.

Gohara Y, Tomonobu N, Kinoshita R, Futami J, Audebert L, Chen Y, Komalasari NLGY, Jiang F, Yoshizawa C, Murata H, Yamamoto KI, Watanabe M, Kumon H, Sakaguchi M
Journal of molecular medicine (Berlin, Germany) 2023 Apr;101(4):431-447

Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells.

Li X, Li Z, Li C, Fang Y, Zhang G, Yan Y, Zhao X, Song X, Zhang Z
Journal of oncology 2022;2022:7224840

Mitochondrial fission factor promotes cisplatin resistancein hepatocellular carcinoma.

Li X, Wu Q, Ma F, Zhang X, Cai L, Yang X
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):301-310

Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target.

Sun W, Zou Y, Cai Z, Huang J, Hong X, Liang Q, Jin W
Cancers 2022 Jul 21;14(14)

The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.

Li R, Guan Z, Bi S, Wang F, He L, Niu X, You Y, Liu Y, Ding Y, Siwko S, Wang N, Zhang Z, Jin Y, Luo J
Cell death & disease 2022 Feb 14;13(2):152

Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma.

Han N, Li X, Wang Y, Wang L, Zhang C, Zhang Z, Ruan M, Zhang C
Journal of Cancer 2021;12(10):3045-3056

KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.

Tian Y, Wang Z, Zheng X, Song W, Cai L, Rane M, Zhao Y
Toxicology and applied pharmacology 2021 Sep 15;427:115654

Interleukin-1β augments the angiogenesis of endothelial progenitor cells in an NF-κB/CXCR7-dependent manner.

Fan X, He L, Dai Q, He J, Chen X, Dai X, Zhang C, Sun D, Meng X, Sun S, Huang J, Chen J, Lin L, Chen L, Tan Y, Yan X
Journal of cellular and molecular medicine 2020 May;24(10):5605-5614

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.

Kuang L, Wu J, Su N, Qi H, Chen H, Zhou S, Xiong Y, Du X, Tan Q, Yang J, Jin M, Luo F, Ouyang J, Zhang B, Wang Z, Jiang W, Chen L, Chen S, Wang Z, Liu P, Yin L, Guo F, Deng C, Chen D, Liu C, Xie Y, Ni Z, Chen L
Annals of the rheumatic diseases 2020 Jan;79(1):112-122

The protective effects of umbilical cord-derived endothelial colony forming cells on hepatic veno-occlusive disease.

Chen L, Zhang J, Liu X, Yao M, Zhang H
Cell biology international 2020 Dec;44(12):2541-2552

Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4.

Wang Y, Zhao L, Han X, Wang Y, Mi J, Wang C, Sun D, Fu Y, Zhao X, Guo H, Wang Q
Frontiers in oncology 2019;9:1487

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells.

Gentilini A, Caligiuri A, Raggi C, Rombouts K, Pinzani M, Lori G, Correnti M, Invernizzi P, Rovida E, Navari N, Di Matteo S, Alvaro D, Banales JM, Rodrigues P, Raschioni C, Donadon M, Di Tommaso L, Marra F
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2246-2256

Overexpression of CXCR7 promotes mesenchymal stem cells to repair phosgene-induced acute lung injury in rats.

Shao Y, Zhou F, He D, Zhang L, Shen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1233-1239

cxcl12 gene engineered endothelial progenitor cells further improve the functions of oligodendrocyte precursor cells.

Yuan F, Chang S, Luo L, Li Y, Wang L, Song Y, Qu M, Zhang Z, Yang GY, Wang Y
Experimental cell research 2018 Jun 15;367(2):222-231

SDF-1/CXCR7 Chemokine Signaling is Induced in the Peri-Infarct Regions in Patients with Ischemic Stroke.

Zhang Y, Zhang H, Lin S, Chen X, Yao Y, Mao X, Shao B, Zhuge Q, Jin K
Aging and disease 2018 Apr;9(2):287-295

Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures.

Sowa JE, Ślusarczyk J, Trojan E, Chamera K, Leśkiewicz M, Regulska M, Kotarska K, Basta-Kaim A
Journal of neuroimmunology 2017 Oct 15;311:79-87

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.

Salazar N, Muñoz D, Kallifatidis G, Singh RK, Jordà M, Lokeshwar BL
Molecular cancer 2014 Aug 28;13:198

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Raji cells were subjected to SDS PAGE followed by western blot with 20423-1-AP(CXCR7 antibody) at dilution of 1:500
Sample type: cell line