MAB42273

antibody from Novus Biologicals

Targeting: ACKR3 CMKOR1, CXCR7, GPR159, RDC1

Provider product page for MAB42273

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Immunohistochemistry [1]
Flow cytometry [1]

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Product number: MAB42273 - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal CXCR7/RDC-1 Antibody
Antibody type: Monoclonal
Description: Protein A or G purified from hybridoma culture supernatant. Detects human CXCR7/RDC-1 in flow cytometry of five distinct human CXCR7 transfectants, but not their respective parental lines.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 ug
Concentration: LYOPH
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

ACKR3 protein structure - MAB42273 shown in red.

Submitted references Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.

Li S, Fong KW, Gritsina G, Zhang A, Zhao JC, Kim J, Sharp A, Yuan W, Aversa C, Yang XJ, Nelson PS, Feng FY, Chinnaiyan AM, de Bono JS, Morrissey C, Rettig MB, Yu J
Cancer research 2019 May 15;79(10):2580-2592

CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells.

Ieranò C, D'Alterio C, Giarra S, Napolitano M, Rea G, Portella L, Santagata A, Trotta AM, Barbieri A, Campani V, Luciano A, Arra C, Anniciello AM, Botti G, Mayol L, De Rosa G, Pacelli R, Scala S
Cell death & disease 2019 Jul 22;10(8):562

Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.

Willems E, Dedobbeleer M, Digregorio M, Lombard A, Goffart N, Lumapat PN, Lambert J, Van den Ackerveken P, Szpakowska M, Chevigné A, Scholtes F, Rogister B
Oncogene 2019 Jan;38(1):73-87

CXCR7 promotes melanoma tumorigenesis via Src kinase signaling.

Xu S, Tang J, Wang C, Liu J, Fu Y, Luo Y
Cell death & disease 2019 Feb 25;10(3):191

The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer.

Wang M, Yang X, Wei M, Wang Z
Journal of Cancer 2018;9(21):3898-3903

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells.

D'huys T, Claes S, Van Loy T, Schols D
Heliyon 2018 Mar;4(3):e00557

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging.

Montpas N, St-Onge G, Nama N, Rhainds D, Benredjem B, Girard M, Hickson G, Pons V, Heveker N
The Journal of biological chemistry 2018 Jan 19;293(3):893-905

G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis.

Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS
Reproductive sciences (Thousand Oaks, Calif.) 2018 Aug;25(8):1168-1174

Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function.

Cheng YH, Eby JM, LaPorte HM, Volkman BF, Majetschak M
PloS one 2017;12(11):e0187949

Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells.

Hira VV, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, Wormer J, der Swaan BV, Lenarčič B, Juliano L, Mehta S, Van Noorden CJ, Lah TT
Biochimica et biophysica acta. Molecular cell research 2017 Mar;1864(3):594-603

CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells.

Zhang M, Qiu L, Zhang Y, Xu D, Zheng JC, Jiang L
Scientific reports 2017 Aug 15;7(1):8289

The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing.

Mühlethaler-Mottet A, Liberman J, Ascenção K, Flahaut M, Balmas Bourloud K, Yan P, Jauquier N, Gross N, Joseph JM
PloS one 2015;10(5):e0125616

SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4.

Walsh TG, Harper MT, Poole AW
Cellular signalling 2015 Jan;27(1):37-46

Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells.

Liu Y, Carson-Walter E, Walter KA
PloS one 2014;9(8):e103938

Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.

Walters MJ, Ebsworth K, Berahovich RD, Penfold ME, Liu SC, Al Omran R, Kioi M, Chernikova SB, Tseng D, Mulkearns-Hubert EE, Sinyuk M, Ransohoff RM, Lathia JD, Karamchandani J, Kohrt HE, Zhang P, Powers JP, Jaen JC, Schall TJ, Merchant M, Recht L, Brown JM
British journal of cancer 2014 Mar 4;110(5):1179-88

COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.

Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, Leveque J, Tas P, Le Dréan Y, Pakdel F
BMC cancer 2014 Jun 6;14:407

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S
Nature 2014 Jan 2;505(7481):97-102

Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.

Liberman J, Sartelet H, Flahaut M, Mühlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph JM, Gross N
PloS one 2012;7(8):e43665

Ubiquitination of CXCR7 controls receptor trafficking.

Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R
PloS one 2012;7(3):e34192

CXCR7 functions as a scavenger for CXCL12 and CXCL11.

Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A, Thelen M
PloS one 2010 Feb 11;5(2):e9175

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: CXCR7/RDC-1 in Human Squamous Cell Carcinoma. CXCR7/RDC-1 in Human Squamous Cell Carcinoma.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Detection of CXCR7/RDC‑1 in MCF‑7 Human Cell Line by Flow Cytometry. Detection of CXCR7/RDC‑1 in MCF‑7 Human Cell Line by Flow Cytometry.