Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 391405 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#391405, RRID:AB_2565682
- Product name
- APC anti-human CXCR7
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antibody clone number
- 10D1-J16
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- CXCR7 transfected L1.2 cells were stained with CXCR7 (clone 10D1-J16) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
- Conjugate
- Red dye