Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB42271P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CXCR7/RDC-1 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human CXCR7/RDC-1 in direct ELISAs. In flow cytometry, reacts specifically with five distinct human CXCR7 transfectants, but does not react with their respective parental lines or mouse CXCR7 transfectants. In flow cytometry, also reacts with monocytes expressing CXCR7, but does not react with MCF-7 cells which have been reported to have surface-expressing CXCR7 using clone 11G8. Due to the conflicting reports published, use of clone 358426 may result in an underestimation of CXCR7 expression on certain cell types.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
AAA62370
- Isotype
- IgG
- Antibody clone number
- 358426
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.
Targeting chemokine receptor CXCR7 inhibits glioma cell proliferation and mobility.
Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells.
GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC.
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
Benredjem B, Girard M, Rhainds D, St-Onge G, Heveker N
The Journal of biological chemistry 2017 Jan 6;292(1):31-42
The Journal of biological chemistry 2017 Jan 6;292(1):31-42
Targeting chemokine receptor CXCR7 inhibits glioma cell proliferation and mobility.
Liu Y, Carson-Walter E, Walter KA
Anticancer research 2015 Jan;35(1):53-64
Anticancer research 2015 Jan;35(1):53-64
Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells.
Liu Y, Carson-Walter E, Walter KA
PloS one 2014;9(8):e103938
PloS one 2014;9(8):e103938
GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC.
Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H
PloS one 2012;7(8):e43255
PloS one 2012;7(8):e43255
Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
Llinàs L, Lázaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
Immunology letters 2011 Jan 30;134(2):113-21
Immunology letters 2011 Jan 30;134(2):113-21
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
McDermott DH, De Ravin SS, Jun HS, Liu Q, Priel DA, Noel P, Takemoto CM, Ojode T, Paul SM, Dunsmore KP, Hilligoss D, Marquesen M, Ulrick J, Kuhns DB, Chou JY, Malech HL, Murphy PM
Blood 2010 Oct 14;116(15):2793-802
Blood 2010 Oct 14;116(15):2793-802
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CXCR7/RDC-1 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human CXCR7/ RDC-1 PE-conjugated Monoclonal Antibody (Catalog # FAB42271P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.